β-Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8+ T cells

Tumors activate β‐catenin in DCs to suppress CD8 immunity by inhibiting cross‐priming; β‐catenin‐suppressed CD8 immunity could be rescued by enhancing cross‐priming. Whereas CD8+ T cells are essential for anti‐tumor immunity, tumors often evade CD8+ T cell surveillance by immunosuppression. As the i...

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Veröffentlicht in:	Journal of leukocyte biology 2014-01, Vol.95 (1), p.179-190
Hauptverfasser:	Liang, Xinjun, Fu, Chunmei, Cui, Weiguo, Ober‐Blöbaum, Julia L., Zahner, Sonja P., Shrikant, Protul A., Clausen, Björn E., Flavell, Richard A., Mellman, Ira, Jiang, Aimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti‐tumor immunity beta Catenin - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cross-Priming - immunology DC vaccine Dendritic Cells - immunology Dendritic Cells - metabolism Immune Tolerance Immunologic Memory Melanoma, Experimental Mice Mice, Knockout Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism
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