Synthesis and Antiprotozoal Activity of Dicationic m‑Terphenyl and 1,3-Dipyridylbenzene Derivatives

4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Plasmodium falciparum, and Leishmania amazonensis. Twenty-three compounds were highly active against T. b. rhodesiense or P. falciparum. Most noteworthy were...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-07, Vol.56 (13), p.5473-5494
Hauptverfasser:	Patrick, Donald A, Ismail, Mohamed A, Arafa, Reem K, Wenzler, Tanja, Zhu, Xiaohua, Pandharkar, Trupti, Jones, Susan Kilgore, Werbovetz, Karl A, Brun, Reto, Boykin, David W, Tidwell, Richard R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Benzene - chemical synthesis Benzene - chemistry Benzene - pharmacology Chagas Disease - parasitology Chagas Disease - prevention & control Female Leishmania donovani - drug effects Mice Mice, Inbred Strains Models, Chemical Molecular Structure Parasitic Sensitivity Tests Plasmodium falciparum - drug effects Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Structure-Activity Relationship Terphenyl Compounds - chemical synthesis Terphenyl Compounds - chemistry Terphenyl Compounds - pharmacology Trypanosoma cruzi - drug effects
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