Pharmacological mechanisms involved in the antinociceptive effects of dexmedetomidine in mice

Dexmedetomidine (DEX) is a α2‐adrenoceptor (α2‐AR) agonist used as an anesthetic adjuvant and as sedative in critical care settings. Typically, α2‐AR agonists release nitric oxide (NO) and subsequently activate NO‐GMPc pathway and have been implicated with antinociception. In this study, we investig...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2014-02, Vol.28 (1), p.104-113
Hauptverfasser:	Rangel, Rafael A. S., Marinho, Bruno G., Fernandes, Patrícia D., de Moura, Roberto S., Lessa, Marcos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals antinociception Biological and medical sciences dexmedetomidine Dexmedetomidine - pharmacology Medical sciences Mice nitric oxide Nitric Oxide - metabolism pain Pain - drug therapy Pain - metabolism Pain Measurement - methods Pharmacology. Drug treatments Receptors, Adrenergic, alpha-2 - metabolism
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