Abnormal blood clot formation induced by temperature responsive polymers by altered fibrin polymerization and platelet binding

Abstract Thermoresponsive polymers (TRPs) have been extensively investigated as smart devices, drug delivery systems and protein conjugates due to their unique phase transition properties. Here, we report the unusual influence of TRPs in blood clotting and the mechanism by which TRPs change the thre...

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Veröffentlicht in:	Biomaterials 2014-03, Vol.35 (8), p.2518-2528
Hauptverfasser:	Lai, Benjamin F.L, Zou, Yuquan, Yang, Xiaoqiang, Yu, Xifei, Kizhakkedathu, Jayachandran N
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Blood Coagulation - physiology Blood Platelets - chemistry Dentistry Fibrin - chemistry Humans Microscopy, Electron, Scanning Platelet Activation - physiology Polymerization Polymers - chemistry Prothrombin - metabolism Temperature Thrombelastography - methods Thromboplastin - metabolism
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