Distinct roles of Akt1 in regulating proliferation, migration and invasion in HepG2 and HCT 116 cells

Elucidating the effects of genes involved in tumors may improve therapeutic strategies for human cancer. Recently, several studies discovered that Akt1 plays a dual role in mediating cell proliferation, migration and invasion, depending on the cell type. However, the pathophysiological role of Akt1...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncology reports 2014-02, Vol.31 (2), p.737-744
Hauptverfasser:	CHEN, LIANG, KANG, QIAO-HUI, CHEN, YING, ZHANG, YA-HONG, LI, QIAN, XIE, SONG-QIANG, WANG, CHAO-JIE
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Akt1 Analysis Androstadienes - pharmacology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Care and treatment Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Diagnosis Evidence-based medicine Gene Expression Regulation, Neoplastic HCT116 Cells Health aspects Hep G2 Cells Humans Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis invasion Kinases Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis migration Neoplasm Invasiveness - genetics NF-kappa B - biosynthesis Phosphatidylinositol 3-Kinases - antagonists & inhibitors proliferation Protein Kinase Inhibitors - pharmacology Protein kinases Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-bcl-2 - biosynthesis Vascular Endothelial Growth Factor A - biosynthesis wortmannin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!