T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases

CD8(+) CTLs are adept at killing virally infected cells and cancer cells and releasing cytokines (e.g., IFN-γ) to aid this response. However, during cancer and chronic viral infections, such as with HIV, this CTL response is progressively impaired due to a process called T cell exhaustion. Previous...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-01, Vol.192 (2), p.782-791
Hauptverfasser:	Clayton, Kiera L, Haaland, Matthew S, Douglas-Vail, Matthew B, Mujib, Shariq, Chew, Glen M, Ndhlovu, Lishomwa C, Ostrowski, Mario A
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes - metabolism Galectins - metabolism Hepatitis A Virus Cellular Receptor 2 HIV Infections - metabolism Humans Leukocyte Common Antigens - metabolism Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Membrane Proteins - metabolism Phosphoric Monoester Hydrolases - metabolism Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism Signal Transduction - physiology Synapses - metabolism
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