Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi
To determine the prevalence of Moraxella catarrhalis in sputum cultures from patients with lower respiratory tract infection and their antimicrobial sensitivity profiles. The study comprised sputum specimens of 776 patients at various branches of Dr Essa's Diagnostic Lab, Karachi. The specimens...
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| Veröffentlicht in: | Journal of the Pakistan Medical Association 2013-11, Vol.63 (11), p.1342-1344 |
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| creator | Abdullah, Farhan Essa Ahuja, Keerat Rai Kumar, Hanesh |
| description | To determine the prevalence of Moraxella catarrhalis in sputum cultures from patients with lower respiratory tract infection and their antimicrobial sensitivity profiles.
The study comprised sputum specimens of 776 patients at various branches of Dr Essa's Diagnostic Lab, Karachi. The specimens were cultured on blood, chocolate, and eosin methylene blue agars between October 2010 and October 2011. The isolates were identified by conventional methods and anti-biograms were determined by the Kirby-Bauer Agar Disc Diffusion Method.
Moraxella catarrhalis was isolated from 39 (5.02%) sputa of which 18 (46.15%) belonged to males. The bimodal age prevalence was 238 (30.7%) in age group 20-29 years, and 180 (23.1%) in 70 years and above. Amoxicillin/clavulanate, cefotaxime, and ceftriaxone were most effective (100%). Very high resistance was seen with amikacin (92.3%), cefixime (92.3%), fosfomycin (84.6%), cefuroxime (84.6%), erythromycin and amoxicillin (76.9%), cotrimoxazole (90%) and doxycycline (76.9%).
The incidence of Moraxella catarrhalis in sputum encourages routine culture and sensitivity of sputa from patients suffering from lower respiratory tract infection, especially the elderly and immunocompromised, for tailored drug prescription. |
| format | Article |
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The study comprised sputum specimens of 776 patients at various branches of Dr Essa's Diagnostic Lab, Karachi. The specimens were cultured on blood, chocolate, and eosin methylene blue agars between October 2010 and October 2011. The isolates were identified by conventional methods and anti-biograms were determined by the Kirby-Bauer Agar Disc Diffusion Method.
Moraxella catarrhalis was isolated from 39 (5.02%) sputa of which 18 (46.15%) belonged to males. The bimodal age prevalence was 238 (30.7%) in age group 20-29 years, and 180 (23.1%) in 70 years and above. Amoxicillin/clavulanate, cefotaxime, and ceftriaxone were most effective (100%). Very high resistance was seen with amikacin (92.3%), cefixime (92.3%), fosfomycin (84.6%), cefuroxime (84.6%), erythromycin and amoxicillin (76.9%), cotrimoxazole (90%) and doxycycline (76.9%).
The incidence of Moraxella catarrhalis in sputum encourages routine culture and sensitivity of sputa from patients suffering from lower respiratory tract infection, especially the elderly and immunocompromised, for tailored drug prescription.</description><identifier>ISSN: 0030-9982</identifier><identifier>PMID: 24392515</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Adult ; Aged ; Cohort Studies ; Drug Resistance, Bacterial ; Female ; Health aspects ; Humans ; Infection ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Moraxella (Branhamella) catarrhalis ; Moraxellaceae Infections - drug therapy ; Moraxellaceae Infections - epidemiology ; Moraxellaceae Infections - microbiology ; Pakistan ; Prevalence ; Prevalence studies (Epidemiology) ; Respiratory tract diseases ; Respiratory Tract Infections - diagnosis ; Respiratory Tract Infections - drug therapy ; Respiratory Tract Infections - microbiology ; Young Adult</subject><ispartof>Journal of the Pakistan Medical Association, 2013-11, Vol.63 (11), p.1342-1344</ispartof><rights>COPYRIGHT 2013 Knowledge Bylanes</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24392515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdullah, Farhan Essa</creatorcontrib><creatorcontrib>Ahuja, Keerat Rai</creatorcontrib><creatorcontrib>Kumar, Hanesh</creatorcontrib><title>Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To determine the prevalence of Moraxella catarrhalis in sputum cultures from patients with lower respiratory tract infection and their antimicrobial sensitivity profiles.
The study comprised sputum specimens of 776 patients at various branches of Dr Essa's Diagnostic Lab, Karachi. The specimens were cultured on blood, chocolate, and eosin methylene blue agars between October 2010 and October 2011. The isolates were identified by conventional methods and anti-biograms were determined by the Kirby-Bauer Agar Disc Diffusion Method.
Moraxella catarrhalis was isolated from 39 (5.02%) sputa of which 18 (46.15%) belonged to males. The bimodal age prevalence was 238 (30.7%) in age group 20-29 years, and 180 (23.1%) in 70 years and above. Amoxicillin/clavulanate, cefotaxime, and ceftriaxone were most effective (100%). Very high resistance was seen with amikacin (92.3%), cefixime (92.3%), fosfomycin (84.6%), cefuroxime (84.6%), erythromycin and amoxicillin (76.9%), cotrimoxazole (90%) and doxycycline (76.9%).
The incidence of Moraxella catarrhalis in sputum encourages routine culture and sensitivity of sputa from patients suffering from lower respiratory tract infection, especially the elderly and immunocompromised, for tailored drug prescription.</description><subject>Adult</subject><subject>Aged</subject><subject>Cohort Studies</subject><subject>Drug Resistance, Bacterial</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infection</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Moraxella (Branhamella) catarrhalis</subject><subject>Moraxellaceae Infections - drug therapy</subject><subject>Moraxellaceae Infections - epidemiology</subject><subject>Moraxellaceae Infections - microbiology</subject><subject>Pakistan</subject><subject>Prevalence</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Respiratory tract diseases</subject><subject>Respiratory Tract Infections - diagnosis</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Young Adult</subject><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1LAzEQhveg2Fr9C7IgiJfKbLIf3WMpfqGiBz0v0-ykjWQ3Ncmq_fdm2woWZA4D7zzv8DJzEA0BOIzLcsIG0bFz7wAszwCOogFLecmyJBtG-sXSJ2pqBcXY1jE1ZBeqXcSWnHIee93I-MlY_CatMRbo0dolauVi1cbafJHt4ZWy6I1dx96i8GEkSXhl2g31gEFcqpPoUKJ2dLrro-jt5vp1djd-fL69n00fxwsOpR_PCyn5BGSSlTIpACaSSUG8TFgJc854mueyBpSiDkxapsQLSgpByAAhSyUfRZfbvStrPjpyvmqUE338lkznqmCCIgPO8oCeb9FFOEIVUps-f49XU55BkhR5UgTq6h8qVE2NEqYlqYK-Z7j4Y1gSar90Rnebi-yDZ7uo3byhulpZ1aBdV78f4j-5o4rc</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Abdullah, Farhan Essa</creator><creator>Ahuja, Keerat Rai</creator><creator>Kumar, Hanesh</creator><general>Knowledge Bylanes</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi</title><author>Abdullah, Farhan Essa ; Ahuja, Keerat Rai ; Kumar, Hanesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g309t-b7ff380f159f17008f2fce391290b323466fd0afcd0f1494e37e17cea20a054f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cohort Studies</topic><topic>Drug Resistance, Bacterial</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infection</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Moraxella (Branhamella) catarrhalis</topic><topic>Moraxellaceae Infections - drug therapy</topic><topic>Moraxellaceae Infections - epidemiology</topic><topic>Moraxellaceae Infections - microbiology</topic><topic>Pakistan</topic><topic>Prevalence</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Respiratory tract diseases</topic><topic>Respiratory Tract Infections - diagnosis</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Abdullah, Farhan Essa</creatorcontrib><creatorcontrib>Ahuja, Keerat Rai</creatorcontrib><creatorcontrib>Kumar, Hanesh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdullah, Farhan Essa</au><au>Ahuja, Keerat Rai</au><au>Kumar, Hanesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>63</volume><issue>11</issue><spage>1342</spage><epage>1344</epage><pages>1342-1344</pages><issn>0030-9982</issn><abstract>To determine the prevalence of Moraxella catarrhalis in sputum cultures from patients with lower respiratory tract infection and their antimicrobial sensitivity profiles.
The study comprised sputum specimens of 776 patients at various branches of Dr Essa's Diagnostic Lab, Karachi. The specimens were cultured on blood, chocolate, and eosin methylene blue agars between October 2010 and October 2011. The isolates were identified by conventional methods and anti-biograms were determined by the Kirby-Bauer Agar Disc Diffusion Method.
Moraxella catarrhalis was isolated from 39 (5.02%) sputa of which 18 (46.15%) belonged to males. The bimodal age prevalence was 238 (30.7%) in age group 20-29 years, and 180 (23.1%) in 70 years and above. Amoxicillin/clavulanate, cefotaxime, and ceftriaxone were most effective (100%). Very high resistance was seen with amikacin (92.3%), cefixime (92.3%), fosfomycin (84.6%), cefuroxime (84.6%), erythromycin and amoxicillin (76.9%), cotrimoxazole (90%) and doxycycline (76.9%).
The incidence of Moraxella catarrhalis in sputum encourages routine culture and sensitivity of sputa from patients suffering from lower respiratory tract infection, especially the elderly and immunocompromised, for tailored drug prescription.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>24392515</pmid><tpages>3</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Cohort Studies Drug Resistance, Bacterial Female Health aspects Humans Infection Male Microbial Sensitivity Tests Middle Aged Moraxella (Branhamella) catarrhalis Moraxellaceae Infections - drug therapy Moraxellaceae Infections - epidemiology Moraxellaceae Infections - microbiology Pakistan Prevalence Prevalence studies (Epidemiology) Respiratory tract diseases Respiratory Tract Infections - diagnosis Respiratory Tract Infections - drug therapy Respiratory Tract Infections - microbiology Young Adult |
| title | Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi |
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