Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells

The HH signaling pathway is a 'core' signal transduction pathway in pancreatic cancer that promotes the tumorigenesis of pancreatic cancers via enhancing cell proliferation, increasing invasion and metastasis and protecting against apoptosis. In the present study, we found that HH signalin...

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Veröffentlicht in:	Oncology reports 2014-02, Vol.31 (2), p.707-712
Hauptverfasser:	XU, YONGHUA, AN, YONG, WANG, XUEHAO, ZHA, WENZHANG, LI, XIANGCHENG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Analysis Animals Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Cancer Cancer therapies Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Care and treatment Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell Transformation, Neoplastic Chemotherapy Diagnosis Female GANT61 Genetic transcription Hedgehog Proteins - antagonists & inhibitors Hedgehog signaling Humans Kinases Kruppel-Like Transcription Factors - antagonists & inhibitors Kruppel-Like Transcription Factors - biosynthesis Metastasis Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis - drug therapy Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - biosynthesis Pancreatic cancer Pancreatic Ducts - pathology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Physiology, Pathological Pyridines - pharmacology Pyrimidines - pharmacology Rodents Signal transduction Signal Transduction - drug effects Studies Transcription Factors - antagonists & inhibitors Transcription Factors - biosynthesis Tumorigenesis Xenograft Model Antitumor Assays Zinc Finger Protein GLI1 Zinc Finger Protein Gli2
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