Mechanisms of subcellular remodeling in heart failure due to diabetes

Diabetic cardiomyopathy is not only associated with heart failure but there also occurs a loss of the positive inotropic effect of different agents. It is now becoming clear that cardiac dysfunction in chronic diabetes is intimately involved with Ca 2+ -handling abnormalities, metabolic defects and...

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Veröffentlicht in:	Heart failure reviews 2014-01, Vol.19 (1), p.87-99
Hauptverfasser:	Dhalla, Naranjan S., Takeda, Nobuakira, Rodriguez-Leyva, Delfin, Elimban, Vijayan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiology Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Disease Progression Heart Failure - metabolism Heart Failure - pathology Heart Failure - physiopathology Humans Insulin - metabolism Medicine Medicine & Public Health Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Myocardium - metabolism Myocardium - ultrastructure Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Oxidative Stress Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - ultrastructure
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