Sex differences in patients with systemic lupus erythematosus from Northwest Spain
To further establish potential differences according to sex in systemic lupus erythematosus (SLE) patients from Southern Europe. We assessed clinical and epidemiological data of patients diagnosed with SLE according to the 1982 American College of Rheumatology classification criteria at the single h...
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| Veröffentlicht in: | Rheumatology international 2014, Vol.34 (1), p.11-24 |
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| creator | Alonso, Maria D. Martínez-Vázquez, Francisco Riancho-Zarrabeitia, Leyre Díaz de Terán, Teresa Miranda-Filloy, Jose A. Blanco, Ricardo González-Juanatey, Carlos Llorca, Javier González-Gay, Miguel A. |
| description | To further establish potential differences according to sex in systemic lupus erythematosus (SLE) patients from Southern Europe. We assessed clinical and epidemiological data of patients diagnosed with SLE according to the 1982 American College of Rheumatology classification criteria at the single hospital for a well-defined population of Northwest Spain, between 1987 and 2006. Prevalence in December 2006 and age-standardized incidence rates in the whole period were estimated. Kaplan–Meier method was used in order to estimate the probability of survivorship. Women outnumbered men [127 (84.7 %) vs. 23 (15.3 %)]. The median age at the time of disease diagnosis in men was 54 years versus 43 in women (
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| doi_str_mv | 10.1007/s00296-013-2798-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490739597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3171732071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-7b474032e0c8bc316d7a9bd8a5abdd5e2d34d00057dd0d475cd5662363870edf3</originalsourceid><addsrcrecordid>eNp1kFtLxDAQhYMo7nr5Ab5IwBdfqpOkTdpHEW8gCl7At5A2U7eyvZik6P57s-wqIvgywzDfnDMcQg4YnDAAdeoBeCETYCLhqsiTYoNMWSpUwiS8bJIpMMWTPJYJ2fH-DeIsJWyTCRc54yD4lDw84ie1TV2jw65CT5uODiY02AVPP5owo37hA7ZNRefjMHqKbhFm2JrQ-zjVrm_pXe_C7AN9oI-Dabo9slWbucf9dd8lz5cXT-fXye391c352W1SCcVDospUpfEHhCovK8GkVaYobW4yU1qbIbcitQCQKWvBpiqrbCYlF1LkCtDWYpccr3QH17-P0V63ja9wPjcd9qPXLC1AiSIrVESP_qBv_ei6-F2klFDRJZWRYiuqcr33Dms9uKY1bqEZ6GXgehW4joHrZeC6iDeHa-WxbNH-XHwnHAG-Anxcda_ofln_q_oFj9SLlw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1473700546</pqid></control><display><type>article</type><title>Sex differences in patients with systemic lupus erythematosus from Northwest Spain</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Alonso, Maria D. ; Martínez-Vázquez, Francisco ; Riancho-Zarrabeitia, Leyre ; Díaz de Terán, Teresa ; Miranda-Filloy, Jose A. ; Blanco, Ricardo ; González-Juanatey, Carlos ; Llorca, Javier ; González-Gay, Miguel A.</creator><creatorcontrib>Alonso, Maria D. ; Martínez-Vázquez, Francisco ; Riancho-Zarrabeitia, Leyre ; Díaz de Terán, Teresa ; Miranda-Filloy, Jose A. ; Blanco, Ricardo ; González-Juanatey, Carlos ; Llorca, Javier ; González-Gay, Miguel A.</creatorcontrib><description>To further establish potential differences according to sex in systemic lupus erythematosus (SLE) patients from Southern Europe. We assessed clinical and epidemiological data of patients diagnosed with SLE according to the 1982 American College of Rheumatology classification criteria at the single hospital for a well-defined population of Northwest Spain, between 1987 and 2006. Prevalence in December 2006 and age-standardized incidence rates in the whole period were estimated. Kaplan–Meier method was used in order to estimate the probability of survivorship. Women outnumbered men [127 (84.7 %) vs. 23 (15.3 %)]. The median age at the time of disease diagnosis in men was 54 years versus 43 in women (
p
< 0.001). Annual incidence rates were higher in women [5.9 (95 % confidence interval—CI 4.9–7.0) per 100,000 population] than in men [1.1 (95 % CI 0.7–1.7) per 100,000 population;
p
< 0.001]. Raynaud’s phenomenon was more common in women (40.9 vs. 3.0 %;
p
= 0.01). While the frequency of secondary Sjögren’s syndrome was increased in women (
p
= 0.02), renal disease at the time of diagnosis (39.1 vs. 15.0 %;
p
< 0.01) and over the course of the disease was more common in men (43.5 vs. 24.4 %;
p
= 0.06). Higher frequency of thrombocytopenia (39.1 vs. 16.5 %;
p
= 0.01) and lower frequency of anti-SSA (13.0 vs. 31.5 %;
p
= 0.08) and anti-SSB (0 vs. 17.7 %;
p
= 0.03) were observed in men. The 5- and 10-year survival probabilities were nonsignificantly reduced in men (91.3 and 78.3 3 % vs. 94.6 and 89.2 % in women). The frequency of some clinical manifestations is different in men and women with SLE. Higher awareness of these peculiarities may help to establish appropriate diagnosis and management of SLE in men.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-013-2798-9</identifier><identifier>PMID: 23812032</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Age Distribution ; Age of Onset ; Aged ; Antibodies, Antinuclear - blood ; Biomarkers - blood ; Female ; Humans ; Incidence ; Kaplan-Meier Estimate ; Logistic Models ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - diagnosis ; Lupus Erythematosus, Systemic - epidemiology ; Lupus Erythematosus, Systemic - mortality ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Prevalence ; Prognosis ; Retrospective Studies ; Review ; Rheumatology ; Risk Factors ; Sex Distribution ; Sex Factors ; Sjogren's Syndrome - epidemiology ; Spain - epidemiology ; Thrombocytopenia - epidemiology ; Time Factors</subject><ispartof>Rheumatology international, 2014, Vol.34 (1), p.11-24</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-7b474032e0c8bc316d7a9bd8a5abdd5e2d34d00057dd0d475cd5662363870edf3</citedby><cites>FETCH-LOGICAL-c372t-7b474032e0c8bc316d7a9bd8a5abdd5e2d34d00057dd0d475cd5662363870edf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-013-2798-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-013-2798-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23812032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alonso, Maria D.</creatorcontrib><creatorcontrib>Martínez-Vázquez, Francisco</creatorcontrib><creatorcontrib>Riancho-Zarrabeitia, Leyre</creatorcontrib><creatorcontrib>Díaz de Terán, Teresa</creatorcontrib><creatorcontrib>Miranda-Filloy, Jose A.</creatorcontrib><creatorcontrib>Blanco, Ricardo</creatorcontrib><creatorcontrib>González-Juanatey, Carlos</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>González-Gay, Miguel A.</creatorcontrib><title>Sex differences in patients with systemic lupus erythematosus from Northwest Spain</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>To further establish potential differences according to sex in systemic lupus erythematosus (SLE) patients from Southern Europe. We assessed clinical and epidemiological data of patients diagnosed with SLE according to the 1982 American College of Rheumatology classification criteria at the single hospital for a well-defined population of Northwest Spain, between 1987 and 2006. Prevalence in December 2006 and age-standardized incidence rates in the whole period were estimated. Kaplan–Meier method was used in order to estimate the probability of survivorship. Women outnumbered men [127 (84.7 %) vs. 23 (15.3 %)]. The median age at the time of disease diagnosis in men was 54 years versus 43 in women (
p
< 0.001). Annual incidence rates were higher in women [5.9 (95 % confidence interval—CI 4.9–7.0) per 100,000 population] than in men [1.1 (95 % CI 0.7–1.7) per 100,000 population;
p
< 0.001]. Raynaud’s phenomenon was more common in women (40.9 vs. 3.0 %;
p
= 0.01). While the frequency of secondary Sjögren’s syndrome was increased in women (
p
= 0.02), renal disease at the time of diagnosis (39.1 vs. 15.0 %;
p
< 0.01) and over the course of the disease was more common in men (43.5 vs. 24.4 %;
p
= 0.06). Higher frequency of thrombocytopenia (39.1 vs. 16.5 %;
p
= 0.01) and lower frequency of anti-SSA (13.0 vs. 31.5 %;
p
= 0.08) and anti-SSB (0 vs. 17.7 %;
p
= 0.03) were observed in men. The 5- and 10-year survival probabilities were nonsignificantly reduced in men (91.3 and 78.3 3 % vs. 94.6 and 89.2 % in women). The frequency of some clinical manifestations is different in men and women with SLE. Higher awareness of these peculiarities may help to establish appropriate diagnosis and management of SLE in men.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Antibodies, Antinuclear - blood</subject><subject>Biomarkers - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kaplan-Meier Estimate</subject><subject>Logistic Models</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Lupus Erythematosus, Systemic - mortality</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Review</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Sjogren's Syndrome - epidemiology</subject><subject>Spain - epidemiology</subject><subject>Thrombocytopenia - epidemiology</subject><subject>Time Factors</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kFtLxDAQhYMo7nr5Ab5IwBdfqpOkTdpHEW8gCl7At5A2U7eyvZik6P57s-wqIvgywzDfnDMcQg4YnDAAdeoBeCETYCLhqsiTYoNMWSpUwiS8bJIpMMWTPJYJ2fH-DeIsJWyTCRc54yD4lDw84ie1TV2jw65CT5uODiY02AVPP5owo37hA7ZNRefjMHqKbhFm2JrQ-zjVrm_pXe_C7AN9oI-Dabo9slWbucf9dd8lz5cXT-fXye391c352W1SCcVDospUpfEHhCovK8GkVaYobW4yU1qbIbcitQCQKWvBpiqrbCYlF1LkCtDWYpccr3QH17-P0V63ja9wPjcd9qPXLC1AiSIrVESP_qBv_ei6-F2klFDRJZWRYiuqcr33Dms9uKY1bqEZ6GXgehW4joHrZeC6iDeHa-WxbNH-XHwnHAG-Anxcda_ofln_q_oFj9SLlw</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Alonso, Maria D.</creator><creator>Martínez-Vázquez, Francisco</creator><creator>Riancho-Zarrabeitia, Leyre</creator><creator>Díaz de Terán, Teresa</creator><creator>Miranda-Filloy, Jose A.</creator><creator>Blanco, Ricardo</creator><creator>González-Juanatey, Carlos</creator><creator>Llorca, Javier</creator><creator>González-Gay, Miguel A.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Sex differences in patients with systemic lupus erythematosus from Northwest Spain</title><author>Alonso, Maria D. ; Martínez-Vázquez, Francisco ; Riancho-Zarrabeitia, Leyre ; Díaz de Terán, Teresa ; Miranda-Filloy, Jose A. ; Blanco, Ricardo ; González-Juanatey, Carlos ; Llorca, Javier ; González-Gay, Miguel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-7b474032e0c8bc316d7a9bd8a5abdd5e2d34d00057dd0d475cd5662363870edf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Antibodies, Antinuclear - blood</topic><topic>Biomarkers - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kaplan-Meier Estimate</topic><topic>Logistic Models</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Lupus Erythematosus, Systemic - mortality</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Review</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Sjogren's Syndrome - epidemiology</topic><topic>Spain - epidemiology</topic><topic>Thrombocytopenia - epidemiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alonso, Maria D.</creatorcontrib><creatorcontrib>Martínez-Vázquez, Francisco</creatorcontrib><creatorcontrib>Riancho-Zarrabeitia, Leyre</creatorcontrib><creatorcontrib>Díaz de Terán, Teresa</creatorcontrib><creatorcontrib>Miranda-Filloy, Jose A.</creatorcontrib><creatorcontrib>Blanco, Ricardo</creatorcontrib><creatorcontrib>González-Juanatey, Carlos</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>González-Gay, Miguel A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alonso, Maria D.</au><au>Martínez-Vázquez, Francisco</au><au>Riancho-Zarrabeitia, Leyre</au><au>Díaz de Terán, Teresa</au><au>Miranda-Filloy, Jose A.</au><au>Blanco, Ricardo</au><au>González-Juanatey, Carlos</au><au>Llorca, Javier</au><au>González-Gay, Miguel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in patients with systemic lupus erythematosus from Northwest Spain</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2014</date><risdate>2014</risdate><volume>34</volume><issue>1</issue><spage>11</spage><epage>24</epage><pages>11-24</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>To further establish potential differences according to sex in systemic lupus erythematosus (SLE) patients from Southern Europe. We assessed clinical and epidemiological data of patients diagnosed with SLE according to the 1982 American College of Rheumatology classification criteria at the single hospital for a well-defined population of Northwest Spain, between 1987 and 2006. Prevalence in December 2006 and age-standardized incidence rates in the whole period were estimated. Kaplan–Meier method was used in order to estimate the probability of survivorship. Women outnumbered men [127 (84.7 %) vs. 23 (15.3 %)]. The median age at the time of disease diagnosis in men was 54 years versus 43 in women (
p
< 0.001). Annual incidence rates were higher in women [5.9 (95 % confidence interval—CI 4.9–7.0) per 100,000 population] than in men [1.1 (95 % CI 0.7–1.7) per 100,000 population;
p
< 0.001]. Raynaud’s phenomenon was more common in women (40.9 vs. 3.0 %;
p
= 0.01). While the frequency of secondary Sjögren’s syndrome was increased in women (
p
= 0.02), renal disease at the time of diagnosis (39.1 vs. 15.0 %;
p
< 0.01) and over the course of the disease was more common in men (43.5 vs. 24.4 %;
p
= 0.06). Higher frequency of thrombocytopenia (39.1 vs. 16.5 %;
p
= 0.01) and lower frequency of anti-SSA (13.0 vs. 31.5 %;
p
= 0.08) and anti-SSB (0 vs. 17.7 %;
p
= 0.03) were observed in men. The 5- and 10-year survival probabilities were nonsignificantly reduced in men (91.3 and 78.3 3 % vs. 94.6 and 89.2 % in women). The frequency of some clinical manifestations is different in men and women with SLE. Higher awareness of these peculiarities may help to establish appropriate diagnosis and management of SLE in men.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23812032</pmid><doi>10.1007/s00296-013-2798-9</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Rheumatology international, 2014, Vol.34 (1), p.11-24 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Age Distribution Age of Onset Aged Antibodies, Antinuclear - blood Biomarkers - blood Female Humans Incidence Kaplan-Meier Estimate Logistic Models Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - mortality Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Odds Ratio Prevalence Prognosis Retrospective Studies Review Rheumatology Risk Factors Sex Distribution Sex Factors Sjogren's Syndrome - epidemiology Spain - epidemiology Thrombocytopenia - epidemiology Time Factors |
| title | Sex differences in patients with systemic lupus erythematosus from Northwest Spain |
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