Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity/insulin resistance

Obstructive sleep apnea syndrome (OSAS) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in obese children. Whether OSAS and intermittent hypoxia are associated with liver injury in pediatric NAFLD is unknown. To assess the relationship of OSAS with liver injury in pediatric N...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2014-01, Vol.189 (1), p.66-76
Hauptverfasser:	Nobili, Valerio, Cutrera, Renato, Liccardo, Daniela, Pavone, Martino, Devito, Rita, Giorgio, Valentina, Verrillo, Elisabetta, Baviera, Giuseppe, Musso, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Apoptosis Biopsy Blood pressure Body mass index C-Reactive Protein - analysis Child Children & youth Confidence intervals Cytokines Diabetes Enzymes Fatty Liver - etiology Fatty Liver - pathology Female Glucose Histology Humans Hyaluronic Acid - blood Hypoxia Insulin Resistance Interleukin-6 - blood Keratin-18 - blood Leukocytes Liver - pathology Liver cirrhosis Liver diseases Male Metabolic syndrome Non-alcoholic Fatty Liver Disease Obesity Obesity - complications Pediatrics Polysomnography Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - pathology Sleep Apnea, Obstructive - physiopathology Triglycerides Tumor Necrosis Factor-alpha - blood
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