Surfactant Replacement Therapy for Preterm and Term Neonates With Respiratory Distress
Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in preterm infants. Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Secondary surfactant deficiency also contributes to acute respiratory morbidity in...
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| Veröffentlicht in: | Pediatrics (Evanston) 2014, Vol.133 (1), p.156-163 |
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| creator | POLIN, Richard A CARLO, Waldemar A |
| description | Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in preterm infants. Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Secondary surfactant deficiency also contributes to acute respiratory morbidity in late-preterm and term neonates with meconium aspiration syndrome, pneumonia/sepsis, and perhaps pulmonary hemorrhage; surfactant replacement may be beneficial for these infants. This statement summarizes the evidence regarding indications, administration, formulations, and outcomes for surfactant-replacement therapy. The clinical strategy of intubation, surfactant administration, and extubation to continuous positive airway pressure and the effect of continuous positive airway pressure on outcomes and surfactant use in preterm infants are also reviewed. |
| doi_str_mv | 10.1542/peds.2013-3443 |
| format | Article |
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Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Secondary surfactant deficiency also contributes to acute respiratory morbidity in late-preterm and term neonates with meconium aspiration syndrome, pneumonia/sepsis, and perhaps pulmonary hemorrhage; surfactant replacement may be beneficial for these infants. This statement summarizes the evidence regarding indications, administration, formulations, and outcomes for surfactant-replacement therapy. 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Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Secondary surfactant deficiency also contributes to acute respiratory morbidity in late-preterm and term neonates with meconium aspiration syndrome, pneumonia/sepsis, and perhaps pulmonary hemorrhage; surfactant replacement may be beneficial for these infants. This statement summarizes the evidence regarding indications, administration, formulations, and outcomes for surfactant-replacement therapy. The clinical strategy of intubation, surfactant administration, and extubation to continuous positive airway pressure and the effect of continuous positive airway pressure on outcomes and surfactant use in preterm infants are also reviewed.</description><subject>Airway management</subject><subject>Babies</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Combined Modality Therapy</subject><subject>Complications and side effects</subject><subject>Continuous Positive Airway Pressure</subject><subject>Drug Administration Schedule</subject><subject>Evaluation</subject><subject>General aspects</subject><subject>Health aspects</subject><subject>Hemorrhage</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants (Premature)</subject><subject>Infectious diseases</subject><subject>Intubation, Intratracheal</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Pediatrics</subject><subject>Pneumology</subject><subject>Premature birth</subject><subject>Premature infants</subject><subject>Pulmonary Surfactants - therapeutic use</subject><subject>Respiratory diseases</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome, Newborn - drug therapy</subject><subject>Respiratory Distress Syndrome, Newborn - therapy</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk factors</subject><subject>Surfactants</subject><subject>Treatment Outcome</subject><subject>United States</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0cuL1EAQBvBGFHd29epRAiLsJWP1K50cl_EJiys66rGpdKp3s-S13R1w_nsTZlTwVHX4VfHBx9gLDluulXgzURO3ArjMpVLyEdtwqMpcCaMfsw2A5LkC0GfsPMZ7AFDaiKfsTChpKiHMhv34NgePLuGQsq80deiop2Xf31HA6ZD5MWRfAiUKfYZDk-3X5TONAyaK2c823S1ncWoDpjEcsrdtTIFifMaeeOwiPT_NC_b9_bv97mN-ffPh0-7qOndK8pRLDd4TNr4RqOtCeG2qpnAaODhVatCIQlW-Lo3StXCNdAg1Uq3Lwhvgpbxgl8e_UxgfZorJ9m101HU40DhHy1UFRpZa8IW--o_ej3MYlnSLMoWqjFJiUflR3WJHth3cOCT6ldzYdXRLdgm_u7FX0kBRVrpcA2yP3oUxxkDeTqHtMRwsB7s2ZNeG7NqQXRtaDl6eYsx1T81f_qeSBbw-AYwOOx9wcG3850phoDKF_A0Wzphg</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>POLIN, Richard A</creator><creator>CARLO, Waldemar A</creator><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Surfactant Replacement Therapy for Preterm and Term Neonates With Respiratory Distress</title><author>POLIN, Richard A ; CARLO, Waldemar A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-350ffeadfd2a5b62f579d6c5010c48505aa249fb8745b2cd3ca0baeb586f70183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Airway management</topic><topic>Babies</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Care and treatment</topic><topic>Combined Modality Therapy</topic><topic>Complications and side effects</topic><topic>Continuous Positive Airway Pressure</topic><topic>Drug Administration Schedule</topic><topic>Evaluation</topic><topic>General aspects</topic><topic>Health aspects</topic><topic>Hemorrhage</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants (Premature)</topic><topic>Infectious diseases</topic><topic>Intubation, Intratracheal</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Pediatrics</topic><topic>Pneumology</topic><topic>Premature birth</topic><topic>Premature infants</topic><topic>Pulmonary Surfactants - therapeutic use</topic><topic>Respiratory diseases</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory Distress Syndrome, Newborn - drug therapy</topic><topic>Respiratory Distress Syndrome, Newborn - therapy</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk factors</topic><topic>Surfactants</topic><topic>Treatment Outcome</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>POLIN, Richard A</creatorcontrib><creatorcontrib>CARLO, Waldemar A</creatorcontrib><creatorcontrib>American Academy of Pediatrics</creatorcontrib><creatorcontrib>Committee on Fetus and Newborn</creatorcontrib><creatorcontrib>COMMITTEE ON FETUS AND NEWBORN</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>POLIN, Richard A</au><au>CARLO, Waldemar A</au><aucorp>American Academy of Pediatrics</aucorp><aucorp>Committee on Fetus and Newborn</aucorp><aucorp>COMMITTEE ON FETUS AND NEWBORN</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactant Replacement Therapy for Preterm and Term Neonates With Respiratory Distress</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2014</date><risdate>2014</risdate><volume>133</volume><issue>1</issue><spage>156</spage><epage>163</epage><pages>156-163</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in preterm infants. Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Secondary surfactant deficiency also contributes to acute respiratory morbidity in late-preterm and term neonates with meconium aspiration syndrome, pneumonia/sepsis, and perhaps pulmonary hemorrhage; surfactant replacement may be beneficial for these infants. This statement summarizes the evidence regarding indications, administration, formulations, and outcomes for surfactant-replacement therapy. The clinical strategy of intubation, surfactant administration, and extubation to continuous positive airway pressure and the effect of continuous positive airway pressure on outcomes and surfactant use in preterm infants are also reviewed.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>24379227</pmid><doi>10.1542/peds.2013-3443</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Airway management Babies Bacterial diseases Bacterial sepsis Biological and medical sciences Care and treatment Combined Modality Therapy Complications and side effects Continuous Positive Airway Pressure Drug Administration Schedule Evaluation General aspects Health aspects Hemorrhage Human bacterial diseases Humans Infant, Newborn Infant, Premature Infants (Premature) Infectious diseases Intubation, Intratracheal Medical sciences Mortality Pediatrics Pneumology Premature birth Premature infants Pulmonary Surfactants - therapeutic use Respiratory diseases Respiratory distress syndrome Respiratory Distress Syndrome, Newborn - drug therapy Respiratory Distress Syndrome, Newborn - therapy Respiratory system : syndromes and miscellaneous diseases Risk factors Surfactants Treatment Outcome United States |
| title | Surfactant Replacement Therapy for Preterm and Term Neonates With Respiratory Distress |
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