Clinical characteristics of collagenous colitis with linear ulcerations
Background The relationship between the thickness of subepithelial collagen bands (CB) and the development of linear ulcerations (LU) in collagenous colitis (CC) remains unclear. The aim of the present study was to compare the clinical and pathological features, including the thickness of CB, in CC...
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| Veröffentlicht in: | Digestive endoscopy 2014-01, Vol.26 (1), p.69-76 |
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| creator | Saito, Sumio Tsumura, Takehiko Nishikawa, Hiroki Takeda, Haruhiko Nakajima, Jun Kanesaka, Takashi Matsuda, Fumihiro Sakamoto, Azusa Henmi, Shinichiro Hatamaru, Keiichi Sekikawa, Akira Kita, Ryuichi Maruo, Takanori Okabe, Yoshihiro Kimura, Toru Wakasa, Tomoko Osaki, Yukio |
| description | Background
The relationship between the thickness of subepithelial collagen bands (CB) and the development of linear ulcerations (LU) in collagenous colitis (CC) remains unclear. The aim of the present study was to compare the clinical and pathological features, including the thickness of CB, in CC patients with and without LU.
Patients and Methods
Twenty‐five patients with CC diagnosed by pathological examination of biopsy specimens were analyzed. Eleven patients with LU (LU group) and 14 patients without LU (non‐LU group) were compared.
Results
Ten patients in the LU group and seven in the non‐LU group were taking lansoprazole (P = 0.038). Seven patients in the LU group and one in the non‐LU group were taking non‐steroidal anti‐inflammatory drugs (NSAIDs) (P = 0.004). All LU were locatedin the transverse or left colon. Patients in the LU group were older than those in the non‐LU group (P = 0.015). CB were significantly thicker in the LU group than in the non‐LU group (mean ± SD, 40 ± 21 μm vs 20 ± 11 μm, P = 0.004). Multivariate analysis showed that NSAIDs use (odds ratio, 19.236; 95% confidence interval, 1.341–275.869) and CB thickness (odds ratio, 0.893; 95% confidence interval, 0.804–0.999) were independently associated with the development of LU.
Conclusion
Use of lansoprazole and NSAIDs, thick CB, and advanced age are associated with the development of LU in CC patients. |
| doi_str_mv | 10.1111/den.12083 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490738054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1490738054</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4223-359bf04832046e07e92d43e13c77f2a68089c1c5086544d513601d82d1bdf3bb3</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EoqWw4AdQlrBI63ecJeoLRFUkBKrExnIchxrSpNipSv8elz52zGZmce7V6ABwjWAXhenlpuoiDAU5AW1EKYkR5-gUtGGKWMw4YS1w4f0nhAinlJ6DFiaMw1SINhj3S1tZrcpIz5VTujHO-sZqH9VFpOuyVB-mqld-e9vG-mhtm3kUMka5aFVq41Rj68pfgrNCld5c7XcHvI2Gr_2HePI8fuzfT2JNMSYxYWlWQCoIhpQbmJgU55QYRHSSFFhxAUWqkWZQcEZpzhDhEOUC5yjLC5JlpANud71LV3-vjG_kwnptwp-VCW9KRFOYEAEZDejdDtWu9t6ZQi6dXSi3kQjKrTcZvMk_b4G92deusoXJj-RBVAB6O2BtS7P5v0kOhtNDZbxLBJ_m55hQ7kvyhCRMzqZjyfFgNH2avch38gsHSIVq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490738054</pqid></control><display><type>article</type><title>Clinical characteristics of collagenous colitis with linear ulcerations</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Saito, Sumio ; Tsumura, Takehiko ; Nishikawa, Hiroki ; Takeda, Haruhiko ; Nakajima, Jun ; Kanesaka, Takashi ; Matsuda, Fumihiro ; Sakamoto, Azusa ; Henmi, Shinichiro ; Hatamaru, Keiichi ; Sekikawa, Akira ; Kita, Ryuichi ; Maruo, Takanori ; Okabe, Yoshihiro ; Kimura, Toru ; Wakasa, Tomoko ; Osaki, Yukio</creator><creatorcontrib>Saito, Sumio ; Tsumura, Takehiko ; Nishikawa, Hiroki ; Takeda, Haruhiko ; Nakajima, Jun ; Kanesaka, Takashi ; Matsuda, Fumihiro ; Sakamoto, Azusa ; Henmi, Shinichiro ; Hatamaru, Keiichi ; Sekikawa, Akira ; Kita, Ryuichi ; Maruo, Takanori ; Okabe, Yoshihiro ; Kimura, Toru ; Wakasa, Tomoko ; Osaki, Yukio</creatorcontrib><description>Background
The relationship between the thickness of subepithelial collagen bands (CB) and the development of linear ulcerations (LU) in collagenous colitis (CC) remains unclear. The aim of the present study was to compare the clinical and pathological features, including the thickness of CB, in CC patients with and without LU.
Patients and Methods
Twenty‐five patients with CC diagnosed by pathological examination of biopsy specimens were analyzed. Eleven patients with LU (LU group) and 14 patients without LU (non‐LU group) were compared.
Results
Ten patients in the LU group and seven in the non‐LU group were taking lansoprazole (P = 0.038). Seven patients in the LU group and one in the non‐LU group were taking non‐steroidal anti‐inflammatory drugs (NSAIDs) (P = 0.004). All LU were locatedin the transverse or left colon. Patients in the LU group were older than those in the non‐LU group (P = 0.015). CB were significantly thicker in the LU group than in the non‐LU group (mean ± SD, 40 ± 21 μm vs 20 ± 11 μm, P = 0.004). Multivariate analysis showed that NSAIDs use (odds ratio, 19.236; 95% confidence interval, 1.341–275.869) and CB thickness (odds ratio, 0.893; 95% confidence interval, 0.804–0.999) were independently associated with the development of LU.
Conclusion
Use of lansoprazole and NSAIDs, thick CB, and advanced age are associated with the development of LU in CC patients.</description><identifier>ISSN: 0915-5635</identifier><identifier>EISSN: 1443-1661</identifier><identifier>DOI: 10.1111/den.12083</identifier><identifier>PMID: 23560988</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-Ulcer Agents - administration & dosage ; Anti-Ulcer Agents - therapeutic use ; Colitis, Collagenous - pathology ; collagen band ; collagenous colitis ; Colonoscopy ; Female ; Humans ; Intestinal Mucosa - pathology ; lansoprazole ; Lansoprazole - administration & dosage ; Lansoprazole - therapeutic use ; linear ulceration ; Male ; Middle Aged ; Multivariate Analysis ; non-steroidal anti-inflammatory drug ; Retrospective Studies</subject><ispartof>Digestive endoscopy, 2014-01, Vol.26 (1), p.69-76</ispartof><rights>2013 The Authors. Digestive Endoscopy © 2013 Japan Gastroenterological Endoscopy Society</rights><rights>2013 The Authors. Digestive Endoscopy © 2013 Japan Gastroenterological Endoscopy Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4223-359bf04832046e07e92d43e13c77f2a68089c1c5086544d513601d82d1bdf3bb3</citedby><cites>FETCH-LOGICAL-c4223-359bf04832046e07e92d43e13c77f2a68089c1c5086544d513601d82d1bdf3bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fden.12083$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fden.12083$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23560988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Sumio</creatorcontrib><creatorcontrib>Tsumura, Takehiko</creatorcontrib><creatorcontrib>Nishikawa, Hiroki</creatorcontrib><creatorcontrib>Takeda, Haruhiko</creatorcontrib><creatorcontrib>Nakajima, Jun</creatorcontrib><creatorcontrib>Kanesaka, Takashi</creatorcontrib><creatorcontrib>Matsuda, Fumihiro</creatorcontrib><creatorcontrib>Sakamoto, Azusa</creatorcontrib><creatorcontrib>Henmi, Shinichiro</creatorcontrib><creatorcontrib>Hatamaru, Keiichi</creatorcontrib><creatorcontrib>Sekikawa, Akira</creatorcontrib><creatorcontrib>Kita, Ryuichi</creatorcontrib><creatorcontrib>Maruo, Takanori</creatorcontrib><creatorcontrib>Okabe, Yoshihiro</creatorcontrib><creatorcontrib>Kimura, Toru</creatorcontrib><creatorcontrib>Wakasa, Tomoko</creatorcontrib><creatorcontrib>Osaki, Yukio</creatorcontrib><title>Clinical characteristics of collagenous colitis with linear ulcerations</title><title>Digestive endoscopy</title><addtitle>Digestive Endoscopy</addtitle><description>Background
The relationship between the thickness of subepithelial collagen bands (CB) and the development of linear ulcerations (LU) in collagenous colitis (CC) remains unclear. The aim of the present study was to compare the clinical and pathological features, including the thickness of CB, in CC patients with and without LU.
Patients and Methods
Twenty‐five patients with CC diagnosed by pathological examination of biopsy specimens were analyzed. Eleven patients with LU (LU group) and 14 patients without LU (non‐LU group) were compared.
Results
Ten patients in the LU group and seven in the non‐LU group were taking lansoprazole (P = 0.038). Seven patients in the LU group and one in the non‐LU group were taking non‐steroidal anti‐inflammatory drugs (NSAIDs) (P = 0.004). All LU were locatedin the transverse or left colon. Patients in the LU group were older than those in the non‐LU group (P = 0.015). CB were significantly thicker in the LU group than in the non‐LU group (mean ± SD, 40 ± 21 μm vs 20 ± 11 μm, P = 0.004). Multivariate analysis showed that NSAIDs use (odds ratio, 19.236; 95% confidence interval, 1.341–275.869) and CB thickness (odds ratio, 0.893; 95% confidence interval, 0.804–0.999) were independently associated with the development of LU.
Conclusion
Use of lansoprazole and NSAIDs, thick CB, and advanced age are associated with the development of LU in CC patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Ulcer Agents - administration & dosage</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Colitis, Collagenous - pathology</subject><subject>collagen band</subject><subject>collagenous colitis</subject><subject>Colonoscopy</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Mucosa - pathology</subject><subject>lansoprazole</subject><subject>Lansoprazole - administration & dosage</subject><subject>Lansoprazole - therapeutic use</subject><subject>linear ulceration</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>non-steroidal anti-inflammatory drug</subject><subject>Retrospective Studies</subject><issn>0915-5635</issn><issn>1443-1661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EoqWw4AdQlrBI63ecJeoLRFUkBKrExnIchxrSpNipSv8elz52zGZmce7V6ABwjWAXhenlpuoiDAU5AW1EKYkR5-gUtGGKWMw4YS1w4f0nhAinlJ6DFiaMw1SINhj3S1tZrcpIz5VTujHO-sZqH9VFpOuyVB-mqld-e9vG-mhtm3kUMka5aFVq41Rj68pfgrNCld5c7XcHvI2Gr_2HePI8fuzfT2JNMSYxYWlWQCoIhpQbmJgU55QYRHSSFFhxAUWqkWZQcEZpzhDhEOUC5yjLC5JlpANud71LV3-vjG_kwnptwp-VCW9KRFOYEAEZDejdDtWu9t6ZQi6dXSi3kQjKrTcZvMk_b4G92deusoXJj-RBVAB6O2BtS7P5v0kOhtNDZbxLBJ_m55hQ7kvyhCRMzqZjyfFgNH2avch38gsHSIVq</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Saito, Sumio</creator><creator>Tsumura, Takehiko</creator><creator>Nishikawa, Hiroki</creator><creator>Takeda, Haruhiko</creator><creator>Nakajima, Jun</creator><creator>Kanesaka, Takashi</creator><creator>Matsuda, Fumihiro</creator><creator>Sakamoto, Azusa</creator><creator>Henmi, Shinichiro</creator><creator>Hatamaru, Keiichi</creator><creator>Sekikawa, Akira</creator><creator>Kita, Ryuichi</creator><creator>Maruo, Takanori</creator><creator>Okabe, Yoshihiro</creator><creator>Kimura, Toru</creator><creator>Wakasa, Tomoko</creator><creator>Osaki, Yukio</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201401</creationdate><title>Clinical characteristics of collagenous colitis with linear ulcerations</title><author>Saito, Sumio ; Tsumura, Takehiko ; Nishikawa, Hiroki ; Takeda, Haruhiko ; Nakajima, Jun ; Kanesaka, Takashi ; Matsuda, Fumihiro ; Sakamoto, Azusa ; Henmi, Shinichiro ; Hatamaru, Keiichi ; Sekikawa, Akira ; Kita, Ryuichi ; Maruo, Takanori ; Okabe, Yoshihiro ; Kimura, Toru ; Wakasa, Tomoko ; Osaki, Yukio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4223-359bf04832046e07e92d43e13c77f2a68089c1c5086544d513601d82d1bdf3bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Ulcer Agents - administration & dosage</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Colitis, Collagenous - pathology</topic><topic>collagen band</topic><topic>collagenous colitis</topic><topic>Colonoscopy</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Mucosa - pathology</topic><topic>lansoprazole</topic><topic>Lansoprazole - administration & dosage</topic><topic>Lansoprazole - therapeutic use</topic><topic>linear ulceration</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>non-steroidal anti-inflammatory drug</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Sumio</creatorcontrib><creatorcontrib>Tsumura, Takehiko</creatorcontrib><creatorcontrib>Nishikawa, Hiroki</creatorcontrib><creatorcontrib>Takeda, Haruhiko</creatorcontrib><creatorcontrib>Nakajima, Jun</creatorcontrib><creatorcontrib>Kanesaka, Takashi</creatorcontrib><creatorcontrib>Matsuda, Fumihiro</creatorcontrib><creatorcontrib>Sakamoto, Azusa</creatorcontrib><creatorcontrib>Henmi, Shinichiro</creatorcontrib><creatorcontrib>Hatamaru, Keiichi</creatorcontrib><creatorcontrib>Sekikawa, Akira</creatorcontrib><creatorcontrib>Kita, Ryuichi</creatorcontrib><creatorcontrib>Maruo, Takanori</creatorcontrib><creatorcontrib>Okabe, Yoshihiro</creatorcontrib><creatorcontrib>Kimura, Toru</creatorcontrib><creatorcontrib>Wakasa, Tomoko</creatorcontrib><creatorcontrib>Osaki, Yukio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Sumio</au><au>Tsumura, Takehiko</au><au>Nishikawa, Hiroki</au><au>Takeda, Haruhiko</au><au>Nakajima, Jun</au><au>Kanesaka, Takashi</au><au>Matsuda, Fumihiro</au><au>Sakamoto, Azusa</au><au>Henmi, Shinichiro</au><au>Hatamaru, Keiichi</au><au>Sekikawa, Akira</au><au>Kita, Ryuichi</au><au>Maruo, Takanori</au><au>Okabe, Yoshihiro</au><au>Kimura, Toru</au><au>Wakasa, Tomoko</au><au>Osaki, Yukio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics of collagenous colitis with linear ulcerations</atitle><jtitle>Digestive endoscopy</jtitle><addtitle>Digestive Endoscopy</addtitle><date>2014-01</date><risdate>2014</risdate><volume>26</volume><issue>1</issue><spage>69</spage><epage>76</epage><pages>69-76</pages><issn>0915-5635</issn><eissn>1443-1661</eissn><abstract>Background
The relationship between the thickness of subepithelial collagen bands (CB) and the development of linear ulcerations (LU) in collagenous colitis (CC) remains unclear. The aim of the present study was to compare the clinical and pathological features, including the thickness of CB, in CC patients with and without LU.
Patients and Methods
Twenty‐five patients with CC diagnosed by pathological examination of biopsy specimens were analyzed. Eleven patients with LU (LU group) and 14 patients without LU (non‐LU group) were compared.
Results
Ten patients in the LU group and seven in the non‐LU group were taking lansoprazole (P = 0.038). Seven patients in the LU group and one in the non‐LU group were taking non‐steroidal anti‐inflammatory drugs (NSAIDs) (P = 0.004). All LU were locatedin the transverse or left colon. Patients in the LU group were older than those in the non‐LU group (P = 0.015). CB were significantly thicker in the LU group than in the non‐LU group (mean ± SD, 40 ± 21 μm vs 20 ± 11 μm, P = 0.004). Multivariate analysis showed that NSAIDs use (odds ratio, 19.236; 95% confidence interval, 1.341–275.869) and CB thickness (odds ratio, 0.893; 95% confidence interval, 0.804–0.999) were independently associated with the development of LU.
Conclusion
Use of lansoprazole and NSAIDs, thick CB, and advanced age are associated with the development of LU in CC patients.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23560988</pmid><doi>10.1111/den.12083</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Anti-Ulcer Agents - administration & dosage Anti-Ulcer Agents - therapeutic use Colitis, Collagenous - pathology collagen band collagenous colitis Colonoscopy Female Humans Intestinal Mucosa - pathology lansoprazole Lansoprazole - administration & dosage Lansoprazole - therapeutic use linear ulceration Male Middle Aged Multivariate Analysis non-steroidal anti-inflammatory drug Retrospective Studies |
| title | Clinical characteristics of collagenous colitis with linear ulcerations |
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