Adhesion to fibronectin induces p27(Kip1) nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cells

Mounting evidence has been shown that integrin-mediated cellular adhesion confers resistance to chemotherapy of multiple myeloma. The molecular mechanism underlying cell adhesion-mediated drug resistance (CAM-DR) is, however, poorly understood. In this report, we demonstrated that RPMI 8,226 cells a...

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Veröffentlicht in:	Molecular and cellular biochemistry 2014-01, Vol.386 (1-2), p.177-187
Hauptverfasser:	Fei, Min, Hang, Qinglei, Hou, Sicong, He, Songbin, Ruan, Changgeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion Cell Line, Tumor Cell Nucleus - metabolism COP9 Signalosome Complex Cyclin-Dependent Kinase Inhibitor p27 - metabolism Down-Regulation Drug Resistance, Neoplasm Fibronectins - metabolism Humans Intracellular Signaling Peptides and Proteins - metabolism Microscopy, Fluorescence Multiple Myeloma - metabolism Multiple Myeloma - pathology Peptide Hydrolases - metabolism Phosphorylation
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