Prevalence and Neonatal Factors Associated with Autism Spectrum Disorders in Preterm Infants
Objectives To determine the prevalence of autism spectrum disorders (ASD) across gestational age, examine the risk of ASD by gestational age controlling for other risk factors, and identify potential risk factors in the neonatal intensive care unit. Study design A retrospective cohort of infants bor...
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| Veröffentlicht in: | The Journal of pediatrics 2014, Vol.164 (1), p.20-25 |
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| container_title | The Journal of pediatrics |
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| creator | Kuzniewicz, Michael W., MD, MPH Wi, Soora, MPH Qian, Yinge, MS Walsh, Eileen M., RN, MPH Armstrong, Mary Anne, MA Croen, Lisa A., PhD |
| description | Objectives To determine the prevalence of autism spectrum disorders (ASD) across gestational age, examine the risk of ASD by gestational age controlling for other risk factors, and identify potential risk factors in the neonatal intensive care unit. Study design A retrospective cohort of infants born at ≥24 weeks between January 1, 2000, and December 31, 2007 at 11 Kaiser Permanente Northern California hospitals (n = 195 021). ASD cases were defined by a diagnosis made at a Kaiser Permanente ASD evaluation center, by a clinical specialist, or by a pediatrician. Cox proportional hazards regression models were used to evaluate the association between gestational age and ASD as well as potential risk factors in the neonatal intensive care unit and ASD. Results The prevalence of ASD in infants |
| doi_str_mv | 10.1016/j.jpeds.2013.09.021 |
| format | Article |
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Study design A retrospective cohort of infants born at ≥24 weeks between January 1, 2000, and December 31, 2007 at 11 Kaiser Permanente Northern California hospitals (n = 195 021). ASD cases were defined by a diagnosis made at a Kaiser Permanente ASD evaluation center, by a clinical specialist, or by a pediatrician. Cox proportional hazards regression models were used to evaluate the association between gestational age and ASD as well as potential risk factors in the neonatal intensive care unit and ASD. Results The prevalence of ASD in infants <37 weeks was 1.78% compared with 1.22% in infants born ≥37 weeks ( P < .001). Compared with term infants, infants born at 24-26 weeks had an adjusted hazard ratio (HR) for a diagnosis of ASD of 2.7 (95% CI 1.5-5.0). Infants born at 27-33 weeks (adjusted HR 1.4, 95% CI 1.1-1.8) and 34-36 weeks (adjusted HR 1.3, 95% CI 1.1-1.4) were also at increased risk. High frequency ventilation and intracranial hemorrhage were associated with ASD in infants < 34 weeks. Conclusions ASD was ∼3 times more prevalent in infants <27 weeks compared with term infants. Each week of shorter gestation was associated with an increased risk of ASD. High frequency ventilation and intracranial hemorrhage were associated with ASD among infants <34 weeks.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2013.09.021</identifier><identifier>PMID: 24161222</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>California - epidemiology ; Child Development Disorders, Pervasive - epidemiology ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - epidemiology ; Infant, Small for Gestational Age ; Male ; Pediatrics ; Prevalence ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors</subject><ispartof>The Journal of pediatrics, 2014, Vol.164 (1), p.20-25</ispartof><rights>Mosby, Inc.</rights><rights>2014 Mosby, Inc.</rights><rights>Copyright © 2014 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-d3b24a936ffcc538308c41ed6acab0200fc6b42e2503396caef79c24475b35033</citedby><cites>FETCH-LOGICAL-c414t-d3b24a936ffcc538308c41ed6acab0200fc6b42e2503396caef79c24475b35033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2013.09.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24161222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuzniewicz, Michael W., MD, MPH</creatorcontrib><creatorcontrib>Wi, Soora, MPH</creatorcontrib><creatorcontrib>Qian, Yinge, MS</creatorcontrib><creatorcontrib>Walsh, Eileen M., RN, MPH</creatorcontrib><creatorcontrib>Armstrong, Mary Anne, MA</creatorcontrib><creatorcontrib>Croen, Lisa A., PhD</creatorcontrib><title>Prevalence and Neonatal Factors Associated with Autism Spectrum Disorders in Preterm Infants</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objectives To determine the prevalence of autism spectrum disorders (ASD) across gestational age, examine the risk of ASD by gestational age controlling for other risk factors, and identify potential risk factors in the neonatal intensive care unit. Study design A retrospective cohort of infants born at ≥24 weeks between January 1, 2000, and December 31, 2007 at 11 Kaiser Permanente Northern California hospitals (n = 195 021). ASD cases were defined by a diagnosis made at a Kaiser Permanente ASD evaluation center, by a clinical specialist, or by a pediatrician. Cox proportional hazards regression models were used to evaluate the association between gestational age and ASD as well as potential risk factors in the neonatal intensive care unit and ASD. Results The prevalence of ASD in infants <37 weeks was 1.78% compared with 1.22% in infants born ≥37 weeks ( P < .001). Compared with term infants, infants born at 24-26 weeks had an adjusted hazard ratio (HR) for a diagnosis of ASD of 2.7 (95% CI 1.5-5.0). Infants born at 27-33 weeks (adjusted HR 1.4, 95% CI 1.1-1.8) and 34-36 weeks (adjusted HR 1.3, 95% CI 1.1-1.4) were also at increased risk. High frequency ventilation and intracranial hemorrhage were associated with ASD in infants < 34 weeks. Conclusions ASD was ∼3 times more prevalent in infants <27 weeks compared with term infants. Each week of shorter gestation was associated with an increased risk of ASD. High frequency ventilation and intracranial hemorrhage were associated with ASD among infants <34 weeks.</description><subject>California - epidemiology</subject><subject>Child Development Disorders, Pervasive - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infant, Small for Gestational Age</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Prevalence</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhFyAhH7kkHX-sszmAtGoprVQBUuGGZDn2RDgkzmI7Rf33OGzhwIXTSJ7nnZGfIeQlg5oBU2dDPRzQpZoDEzW0NXD2iGwYtE2ldkI8JhsAzishG3VCnqU0AEArAZ6SEy6ZYpzzDfn6KeKdGTFYpCY4-gHnYLIZ6aWxeY6J7lOarTcZHf3p8ze6X7JPE709oM1xmeiFT3N0WEgfaBmWMU70OvQm5PScPOnNmPDFQz0lXy7ffT6_qm4-vr8-399UVjKZKyc6Lk0rVN9buxU7AbvSQKeMNR1wgN6qTnLkWxCiVdZg37SWS9lsO7G-nZLXx7mHOP9YMGU9-WRxHE3AeUmayRYaIRouCyqOqI1zShF7fYh-MvFeM9CrVj3o31r1qlVDq4vWknr1sGDpJnR_M388FuDNEcDyzTuPUSfrV6nOxyJKu9n_Z8Hbf_J29MFbM37He0zDvMRQDGqmE9egb9fLrodlAhiTXIlfaVaetA</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Kuzniewicz, Michael W., MD, MPH</creator><creator>Wi, Soora, MPH</creator><creator>Qian, Yinge, MS</creator><creator>Walsh, Eileen M., RN, MPH</creator><creator>Armstrong, Mary Anne, MA</creator><creator>Croen, Lisa A., PhD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Prevalence and Neonatal Factors Associated with Autism Spectrum Disorders in Preterm Infants</title><author>Kuzniewicz, Michael W., MD, MPH ; Wi, Soora, MPH ; Qian, Yinge, MS ; Walsh, Eileen M., RN, MPH ; Armstrong, Mary Anne, MA ; Croen, Lisa A., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-d3b24a936ffcc538308c41ed6acab0200fc6b42e2503396caef79c24475b35033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>California - epidemiology</topic><topic>Child Development Disorders, Pervasive - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - epidemiology</topic><topic>Infant, Small for Gestational Age</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Prevalence</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuzniewicz, Michael W., MD, MPH</creatorcontrib><creatorcontrib>Wi, Soora, MPH</creatorcontrib><creatorcontrib>Qian, Yinge, MS</creatorcontrib><creatorcontrib>Walsh, Eileen M., RN, MPH</creatorcontrib><creatorcontrib>Armstrong, Mary Anne, MA</creatorcontrib><creatorcontrib>Croen, Lisa A., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuzniewicz, Michael W., MD, MPH</au><au>Wi, Soora, MPH</au><au>Qian, Yinge, MS</au><au>Walsh, Eileen M., RN, MPH</au><au>Armstrong, Mary Anne, MA</au><au>Croen, Lisa A., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Neonatal Factors Associated with Autism Spectrum Disorders in Preterm Infants</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2014</date><risdate>2014</risdate><volume>164</volume><issue>1</issue><spage>20</spage><epage>25</epage><pages>20-25</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Objectives To determine the prevalence of autism spectrum disorders (ASD) across gestational age, examine the risk of ASD by gestational age controlling for other risk factors, and identify potential risk factors in the neonatal intensive care unit. Study design A retrospective cohort of infants born at ≥24 weeks between January 1, 2000, and December 31, 2007 at 11 Kaiser Permanente Northern California hospitals (n = 195 021). ASD cases were defined by a diagnosis made at a Kaiser Permanente ASD evaluation center, by a clinical specialist, or by a pediatrician. Cox proportional hazards regression models were used to evaluate the association between gestational age and ASD as well as potential risk factors in the neonatal intensive care unit and ASD. Results The prevalence of ASD in infants <37 weeks was 1.78% compared with 1.22% in infants born ≥37 weeks ( P < .001). Compared with term infants, infants born at 24-26 weeks had an adjusted hazard ratio (HR) for a diagnosis of ASD of 2.7 (95% CI 1.5-5.0). Infants born at 27-33 weeks (adjusted HR 1.4, 95% CI 1.1-1.8) and 34-36 weeks (adjusted HR 1.3, 95% CI 1.1-1.4) were also at increased risk. High frequency ventilation and intracranial hemorrhage were associated with ASD in infants < 34 weeks. Conclusions ASD was ∼3 times more prevalent in infants <27 weeks compared with term infants. Each week of shorter gestation was associated with an increased risk of ASD. High frequency ventilation and intracranial hemorrhage were associated with ASD among infants <34 weeks.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>24161222</pmid><doi>10.1016/j.jpeds.2013.09.021</doi><tpages>6</tpages></addata></record> |
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| subjects | California - epidemiology Child Development Disorders, Pervasive - epidemiology Female Follow-Up Studies Gestational Age Humans Incidence Infant, Newborn Infant, Premature Infant, Premature, Diseases - epidemiology Infant, Small for Gestational Age Male Pediatrics Prevalence Proportional Hazards Models Retrospective Studies Risk Factors |
| title | Prevalence and Neonatal Factors Associated with Autism Spectrum Disorders in Preterm Infants |
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