Transglutaminase activity arising from Factor XIIIA is required for stabilization and conversion of plasma fibronectin into matrix in osteoblast cultures

Abstract Circulating plasma fibronectin (pFN), produced by hepatocytes, is a major component of the noncollagenous bone matrix where it was recently shown in vivo in mice to control the biomechanical quality as well as the mineral-to-matrix ratio in bone. FN fibrillogenesis is a process generally re...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2014-02, Vol.59, p.127-138
Hauptverfasser:	Cui, Cui, Wang, Shuai, Myneni, Vamsee D, Hitomi, Kiyotaka, Kaartinen, Mari T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Biological and medical sciences Cattle Cell Differentiation Cell Line Collagen type I Collagen Type I - metabolism Cross-Linking Reagents - metabolism Extracellular matrix Extracellular Matrix - metabolism Factor XIIIA Factor XIIIa - metabolism Fibronectins - blood Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - antagonists & inhibitors GTP-Binding Proteins - metabolism Humans Mice Mice, Inbred C57BL Models, Biological Orthopedics Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteoblasts - ultrastructure Plasma fibronectin Solubility Substrate Specificity Transglutaminase Transglutaminases - antagonists & inhibitors Transglutaminases - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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