Fabrication of Highly Uniform Gel Coatings by the Conversion of Surface-Anchored Metal–Organic Frameworks
We report the fabrication of 3D, highly porous, covalently bound polymer films of homogeneous thickness. These surface-bound gels combine the advantages of metal–organic framework (MOF) materials, namely, the enormous flexibility and the large size of the maximum pore structures and, in particular,...
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| Veröffentlicht in: | Journal of the American Chemical Society 2014-01, Vol.136 (1), p.8-11 |
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| container_title | Journal of the American Chemical Society |
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| creator | Tsotsalas, Manuel Liu, Jinxuan Tettmann, Beatrix Grosjean, Sylvain Shahnas, Artak Wang, Zhengbang Azucena, Carlos Addicoat, Matthew Heine, Thomas Lahann, Joerg Overhage, Jörg Bräse, Stefan Gliemann, Hartmut Wöll, Christof |
| description | We report the fabrication of 3D, highly porous, covalently bound polymer films of homogeneous thickness. These surface-bound gels combine the advantages of metal–organic framework (MOF) materials, namely, the enormous flexibility and the large size of the maximum pore structures and, in particular, the possibility to grow them epitaxially on modified substrates, with those of covalently connected gel materials, namely, the absence of metal ions in the deposited material, a robust framework consisting of covalent bonds, and, most importantly, pronounced stability under biological conditions. The conversion of a SURMOF (surface-mounted MOF) yields a surface-grafted gel. These SURGELs can be loaded with bioactive compounds and applied as bioactive coatings and provide a drug-release platform in in vitro cell culture studies. |
| doi_str_mv | 10.1021/ja409205s |
| format | Article |
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Am. Chem. Soc</addtitle><description>We report the fabrication of 3D, highly porous, covalently bound polymer films of homogeneous thickness. These surface-bound gels combine the advantages of metal–organic framework (MOF) materials, namely, the enormous flexibility and the large size of the maximum pore structures and, in particular, the possibility to grow them epitaxially on modified substrates, with those of covalently connected gel materials, namely, the absence of metal ions in the deposited material, a robust framework consisting of covalent bonds, and, most importantly, pronounced stability under biological conditions. The conversion of a SURMOF (surface-mounted MOF) yields a surface-grafted gel. These SURGELs can be loaded with bioactive compounds and applied as bioactive coatings and provide a drug-release platform in in vitro cell culture studies.</description><subject>Bacteria</subject><subject>Click Chemistry</subject><subject>Copper - chemistry</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Gels - chemistry</subject><subject>Microscopy, Atomic Force</subject><subject>Organometallic Compounds - chemistry</subject><subject>Particle Size</subject><subject>Porosity</subject><subject>Surface Properties</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1OwzAQhS0EouVnwQWQN0iwCNiOUzvLqqItUlEX0HU0ce02bRIXOwF1xx24ISfBqKUrVjNP75snzUPoipJ7Shh9WAEnKSOJP0JdmjASJZT1jlGXEMIiIXtxB515vwqSM0lPUYfxmEkmRReth5C7QkFT2Bpbg8fFYllu8awujHUVHukSD2xw64XH-RY3Sx10_a6d3x-8tM6A0lG_Vkvr9Bw_6wbK78-vqVtAXSg8dFDpD-vW_gKdGCi9vtzPczQbPr4OxtFkOnoa9CcRcCqbKFdAmUmMSnImKDcS4hxMnqSc0TR4WoMWzEBwUwoi5xB2AqKXiJRRyeNzdLvL3Tj71mrfZFXhlS5LqLVtfUZ5SgSTMhUBvduhylnvnTbZxhUVuG1GSfbbbXboNrDX-9g2r_T8QP6VGYCbHQDKZyvbujp8-U_QDxAygjE</recordid><startdate>20140108</startdate><enddate>20140108</enddate><creator>Tsotsalas, Manuel</creator><creator>Liu, Jinxuan</creator><creator>Tettmann, Beatrix</creator><creator>Grosjean, Sylvain</creator><creator>Shahnas, Artak</creator><creator>Wang, Zhengbang</creator><creator>Azucena, Carlos</creator><creator>Addicoat, Matthew</creator><creator>Heine, Thomas</creator><creator>Lahann, Joerg</creator><creator>Overhage, Jörg</creator><creator>Bräse, Stefan</creator><creator>Gliemann, Hartmut</creator><creator>Wöll, Christof</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140108</creationdate><title>Fabrication of Highly Uniform Gel Coatings by the Conversion of Surface-Anchored Metal–Organic Frameworks</title><author>Tsotsalas, Manuel ; Liu, Jinxuan ; Tettmann, Beatrix ; Grosjean, Sylvain ; Shahnas, Artak ; Wang, Zhengbang ; Azucena, Carlos ; Addicoat, Matthew ; Heine, Thomas ; Lahann, Joerg ; Overhage, Jörg ; Bräse, Stefan ; Gliemann, Hartmut ; Wöll, Christof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-bca12f5fc5b2714f8a3bafb594219ca1eeae72fab2791a7b4afab0a7657921843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Bacteria</topic><topic>Click Chemistry</topic><topic>Copper - chemistry</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Gels - chemistry</topic><topic>Microscopy, Atomic Force</topic><topic>Organometallic Compounds - chemistry</topic><topic>Particle Size</topic><topic>Porosity</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsotsalas, Manuel</creatorcontrib><creatorcontrib>Liu, Jinxuan</creatorcontrib><creatorcontrib>Tettmann, Beatrix</creatorcontrib><creatorcontrib>Grosjean, Sylvain</creatorcontrib><creatorcontrib>Shahnas, Artak</creatorcontrib><creatorcontrib>Wang, Zhengbang</creatorcontrib><creatorcontrib>Azucena, Carlos</creatorcontrib><creatorcontrib>Addicoat, Matthew</creatorcontrib><creatorcontrib>Heine, Thomas</creatorcontrib><creatorcontrib>Lahann, Joerg</creatorcontrib><creatorcontrib>Overhage, Jörg</creatorcontrib><creatorcontrib>Bräse, Stefan</creatorcontrib><creatorcontrib>Gliemann, Hartmut</creatorcontrib><creatorcontrib>Wöll, Christof</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsotsalas, Manuel</au><au>Liu, Jinxuan</au><au>Tettmann, Beatrix</au><au>Grosjean, Sylvain</au><au>Shahnas, Artak</au><au>Wang, Zhengbang</au><au>Azucena, Carlos</au><au>Addicoat, Matthew</au><au>Heine, Thomas</au><au>Lahann, Joerg</au><au>Overhage, Jörg</au><au>Bräse, Stefan</au><au>Gliemann, Hartmut</au><au>Wöll, Christof</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication of Highly Uniform Gel Coatings by the Conversion of Surface-Anchored Metal–Organic Frameworks</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. 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| subjects | Bacteria Click Chemistry Copper - chemistry Cross-Linking Reagents - chemistry Gels - chemistry Microscopy, Atomic Force Organometallic Compounds - chemistry Particle Size Porosity Surface Properties |
| title | Fabrication of Highly Uniform Gel Coatings by the Conversion of Surface-Anchored Metal–Organic Frameworks |
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