The role of complement in mAb-based therapies of cancer

The ability of complement to promote lysis of antibody-opsonized cells is well-established. Virtually all of the molecular details of this reaction have been elucidated and numerous points of regulation have also been delineated. Use of this information, along with the techniques that were first app...

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Veröffentlicht in:	Methods (San Diego, Calif.) Calif.), 2014-01, Vol.65 (1), p.18-27
Hauptverfasser:	Taylor, Ronald P., Lindorfer, Margaret A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cancer Complement Complement Activation - drug effects Complement System Proteins - physiology Cytotoxicity, Immunologic Drug Screening Assays, Antitumor Humans mAb-based immunotherapy Neoplasms - drug therapy Neoplasms - immunology
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