Periodontitis increases vascular cyclooxygenase-2: potential effect on vascular tone

Background and objective It has been demonstrated that periodontitis induces a systemic inflammation, which may impair endothelial function. Cyclooxygenase‐2 (COX‐2) is an important enzyme in the inflammatory process and is responsible for prostacyclin production. We hypothesised that in periodontit...

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Veröffentlicht in:	Journal of periodontal research 2014-02, Vol.49 (1), p.85-92
Hauptverfasser:	Mendes, R. T., Sordi, R., Olchanheski Jr, L. R., Machado, W. M., Stanczyk, C. P., Assreuy, J., Santos, F. A., Fernandes, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Bone Loss - enzymology Alveolar Bone Loss - prevention & control Animals Anti-Inflammatory Agents - pharmacology Arterial Pressure - drug effects Arterial Pressure - physiology blood pressure cardiovascular diseases Cyclooxygenase 2 - drug effects Cyclooxygenase 2 - physiology Cyclooxygenase 2 Inhibitors - pharmacology cyclooxygenase-2 Dentistry Disease Models, Animal Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Heart Rate - drug effects Male Mesenteric Arteries - enzymology Nitric Oxide - blood periodontitis Periodontitis - enzymology Periodontitis - prevention & control Pyridines - pharmacology Random Allocation Rats, Wistar Sulfones - pharmacology Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology
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