Protein engineering and the use of molecular modeling and simulation: The case of heterodimeric Fc engineering

Computational and structure guided methods can make significant contributions to the development of solutions for difficult protein engineering problems, including the optimization of next generation of engineered antibodies. In this paper, we describe a contemporary industrial antibody engineering...

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Veröffentlicht in:	Methods (San Diego, Calif.) Calif.), 2014-01, Vol.65 (1), p.77-94
Hauptverfasser:	Spreter Von Kreudenstein, Thomas, Lario, Paula I., Dixit, Surjit B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Antibody engineering Antibody Specificity Binding Sites Bispecific antibody Computational protein engineering Fc engineering Heterodimeric antibody Humans Hydrogen Bonding Immunoglobulin Fc Fragments - biosynthesis Immunoglobulin Fc Fragments - chemistry Immunoglobulin Fc Fragments - genetics Molecular Dynamics Simulation Protein Engineering Protein Stability Protein Structure, Secondary
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