Reprogramming macrophages to an anti‐inflammatory phenotype by helminth antigens reduces murine atherosclerosis

Atherosclerosis is a lipid‐driven inflammatory disease of the vessel wall, characterized by the chronic activation of macrophages. We investigated whether the helminth‐derived antigens [soluble egg antigens (SEAs)] could modulate macrophage inflammatory responses and protect against atherosclerosis...

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Veröffentlicht in:	The FASEB journal 2014-01, Vol.28 (1), p.288-299
Hauptverfasser:	Wolfs, Ine M. J., Stöger, J. Lauran, Goossens, Pieter, Pöttgens, Chantal, Gijbels, Marion J. J., Wijnands, Erwin, Vorst, Emiel P. C., Gorp, Patrick, Beckers, Linda, Engel, David, Biessen, Erik A. L., Kraal, Georg, Die, Irma, Donners, Marjo M. P. C., Winther, Menno P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Helminth - metabolism Atherosclerosis - metabolism Atherosclerosis - therapy Chemokine CCL2 - metabolism immune modulation inflammation Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains monocytes mouse Receptors, LDL - genetics Receptors, LDL - metabolism schistosome Tumor Necrosis Factor-alpha - metabolism
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