Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients
Background Mucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease‐specific survival (DSS) of parotid MEC and the first population‐level study of the distribution of nodal metastases. Methods Patients with MEC of the par...
Gespeichert in:
| Veröffentlicht in: | Head & neck 2014-02, Vol.36 (2), p.158-163 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 163 |
|---|---|
| container_issue | 2 |
| container_start_page | 158 |
| container_title | Head & neck |
| container_volume | 36 |
| creator | Chen, Michelle M. Roman, Sanziana A. Sosa, Julie A. Judson, Benjamin L. |
| description | Background
Mucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease‐specific survival (DSS) of parotid MEC and the first population‐level study of the distribution of nodal metastases.
Methods
Patients with MEC of the parotid gland were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1988–2009).
Results
We identified 2400 patients with MEC: 522 low grade, 1137 intermediate grade, and 741 high grade. Five‐year DSS rates for low‐grade, intermediate‐grade, and high‐grade MEC were 98.8%, 97.4%, and 67.0%, respectively (p < .001). Negative prognostic factors included high grade, increasing patient age, and tumor size, extraparenchymal extension, nodal metastases, and distant metastases. High‐grade MEC was more likely to have lymph node metastases in levels I to III (34.0%) than low‐grade (3.3%) and intermediate‐grade MEC (8.1%; p < .001).
Conclusion
Grade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. © 2013 Wiley Periodicals, Inc. Head Neck 36: 158–163, 2014 |
| doi_str_mv | 10.1002/hed.23256 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490723006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3177545331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4576-ea4ed3c4c28f5bd0e123cf0391fd17b09032a9f78a653bc92afb2ea548ff1d173</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0EomXhwBdAlrjQQ9rxn9gbblUpXaQVSCtQJS6W49iLixMHO6Hst8fLdjkgcbBsPf_mjWYeQi8JnBMAevHNdueU0Vo8QqcEGlkB4_Lx_s1ZxUDyE_Qs5zsAYILTp-iEMinqJcApyiufpxji1hu8TbqzWGc8prgdYp6K5ofOGz3FhF05_WyiHX1nUx99h41Oxg-x12_xJR7jOAc9-ThUwf60AetBh132GUeHKQfAY_m1w5SfoydOh2xfPNwL9OX99eerVbX-dPPh6nJdGV5LUVnNbccMN3Tp6rYDSygzDlhDXEdkCw0wqhsnl1rUrDUN1a6lVtd86RwpBFugNwffMs-P2eZJ9T4bG4IebJyzIrwBSRmAKOjrf9C7OKcywJ6SgoqmKU0W6OxAmRRzTtapMflep50ioPZJqJKE-pNEYV89OM5tX9QjeVx9AS4OwL0Pdvd_J7W6fne0rA4VJTL762-FTt-VkEzW6vbjjbqFzWbNvjZqw34DorqiHw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1476269965</pqid></control><display><type>article</type><title>Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chen, Michelle M. ; Roman, Sanziana A. ; Sosa, Julie A. ; Judson, Benjamin L.</creator><creatorcontrib>Chen, Michelle M. ; Roman, Sanziana A. ; Sosa, Julie A. ; Judson, Benjamin L.</creatorcontrib><description>Background
Mucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease‐specific survival (DSS) of parotid MEC and the first population‐level study of the distribution of nodal metastases.
Methods
Patients with MEC of the parotid gland were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1988–2009).
Results
We identified 2400 patients with MEC: 522 low grade, 1137 intermediate grade, and 741 high grade. Five‐year DSS rates for low‐grade, intermediate‐grade, and high‐grade MEC were 98.8%, 97.4%, and 67.0%, respectively (p < .001). Negative prognostic factors included high grade, increasing patient age, and tumor size, extraparenchymal extension, nodal metastases, and distant metastases. High‐grade MEC was more likely to have lymph node metastases in levels I to III (34.0%) than low‐grade (3.3%) and intermediate‐grade MEC (8.1%; p < .001).
Conclusion
Grade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. © 2013 Wiley Periodicals, Inc. Head Neck 36: 158–163, 2014</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23256</identifier><identifier>PMID: 23765800</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aged ; Carcinoma, Mucoepidermoid - epidemiology ; Carcinoma, Mucoepidermoid - pathology ; Carcinoma, Mucoepidermoid - radiotherapy ; Female ; Humans ; Incidence ; lymph node metastases ; Male ; Middle Aged ; mucoepidermoid carcinoma ; Neoplasm Grading ; parotid gland ; Parotid Neoplasms - epidemiology ; Parotid Neoplasms - pathology ; Parotid Neoplasms - radiotherapy ; Prognosis ; Risk Factors ; salivary gland carcinoma ; survival ; Treatment Outcome ; United States - epidemiology</subject><ispartof>Head & neck, 2014-02, Vol.36 (2), p.158-163</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4576-ea4ed3c4c28f5bd0e123cf0391fd17b09032a9f78a653bc92afb2ea548ff1d173</citedby><cites>FETCH-LOGICAL-c4576-ea4ed3c4c28f5bd0e123cf0391fd17b09032a9f78a653bc92afb2ea548ff1d173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23256$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23256$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23765800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Michelle M.</creatorcontrib><creatorcontrib>Roman, Sanziana A.</creatorcontrib><creatorcontrib>Sosa, Julie A.</creatorcontrib><creatorcontrib>Judson, Benjamin L.</creatorcontrib><title>Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Mucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease‐specific survival (DSS) of parotid MEC and the first population‐level study of the distribution of nodal metastases.
Methods
Patients with MEC of the parotid gland were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1988–2009).
Results
We identified 2400 patients with MEC: 522 low grade, 1137 intermediate grade, and 741 high grade. Five‐year DSS rates for low‐grade, intermediate‐grade, and high‐grade MEC were 98.8%, 97.4%, and 67.0%, respectively (p < .001). Negative prognostic factors included high grade, increasing patient age, and tumor size, extraparenchymal extension, nodal metastases, and distant metastases. High‐grade MEC was more likely to have lymph node metastases in levels I to III (34.0%) than low‐grade (3.3%) and intermediate‐grade MEC (8.1%; p < .001).
Conclusion
Grade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. © 2013 Wiley Periodicals, Inc. Head Neck 36: 158–163, 2014</description><subject>Aged</subject><subject>Carcinoma, Mucoepidermoid - epidemiology</subject><subject>Carcinoma, Mucoepidermoid - pathology</subject><subject>Carcinoma, Mucoepidermoid - radiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>lymph node metastases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>mucoepidermoid carcinoma</subject><subject>Neoplasm Grading</subject><subject>parotid gland</subject><subject>Parotid Neoplasms - epidemiology</subject><subject>Parotid Neoplasms - pathology</subject><subject>Parotid Neoplasms - radiotherapy</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>salivary gland carcinoma</subject><subject>survival</subject><subject>Treatment Outcome</subject><subject>United States - epidemiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxS0EomXhwBdAlrjQQ9rxn9gbblUpXaQVSCtQJS6W49iLixMHO6Hst8fLdjkgcbBsPf_mjWYeQi8JnBMAevHNdueU0Vo8QqcEGlkB4_Lx_s1ZxUDyE_Qs5zsAYILTp-iEMinqJcApyiufpxji1hu8TbqzWGc8prgdYp6K5ofOGz3FhF05_WyiHX1nUx99h41Oxg-x12_xJR7jOAc9-ThUwf60AetBh132GUeHKQfAY_m1w5SfoydOh2xfPNwL9OX99eerVbX-dPPh6nJdGV5LUVnNbccMN3Tp6rYDSygzDlhDXEdkCw0wqhsnl1rUrDUN1a6lVtd86RwpBFugNwffMs-P2eZJ9T4bG4IebJyzIrwBSRmAKOjrf9C7OKcywJ6SgoqmKU0W6OxAmRRzTtapMflep50ioPZJqJKE-pNEYV89OM5tX9QjeVx9AS4OwL0Pdvd_J7W6fne0rA4VJTL762-FTt-VkEzW6vbjjbqFzWbNvjZqw34DorqiHw</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Chen, Michelle M.</creator><creator>Roman, Sanziana A.</creator><creator>Sosa, Julie A.</creator><creator>Judson, Benjamin L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients</title><author>Chen, Michelle M. ; Roman, Sanziana A. ; Sosa, Julie A. ; Judson, Benjamin L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4576-ea4ed3c4c28f5bd0e123cf0391fd17b09032a9f78a653bc92afb2ea548ff1d173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Carcinoma, Mucoepidermoid - epidemiology</topic><topic>Carcinoma, Mucoepidermoid - pathology</topic><topic>Carcinoma, Mucoepidermoid - radiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>lymph node metastases</topic><topic>Male</topic><topic>Middle Aged</topic><topic>mucoepidermoid carcinoma</topic><topic>Neoplasm Grading</topic><topic>parotid gland</topic><topic>Parotid Neoplasms - epidemiology</topic><topic>Parotid Neoplasms - pathology</topic><topic>Parotid Neoplasms - radiotherapy</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>salivary gland carcinoma</topic><topic>survival</topic><topic>Treatment Outcome</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Michelle M.</creatorcontrib><creatorcontrib>Roman, Sanziana A.</creatorcontrib><creatorcontrib>Sosa, Julie A.</creatorcontrib><creatorcontrib>Judson, Benjamin L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Michelle M.</au><au>Roman, Sanziana A.</au><au>Sosa, Julie A.</au><au>Judson, Benjamin L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-02</date><risdate>2014</risdate><volume>36</volume><issue>2</issue><spage>158</spage><epage>163</epage><pages>158-163</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Mucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease‐specific survival (DSS) of parotid MEC and the first population‐level study of the distribution of nodal metastases.
Methods
Patients with MEC of the parotid gland were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1988–2009).
Results
We identified 2400 patients with MEC: 522 low grade, 1137 intermediate grade, and 741 high grade. Five‐year DSS rates for low‐grade, intermediate‐grade, and high‐grade MEC were 98.8%, 97.4%, and 67.0%, respectively (p < .001). Negative prognostic factors included high grade, increasing patient age, and tumor size, extraparenchymal extension, nodal metastases, and distant metastases. High‐grade MEC was more likely to have lymph node metastases in levels I to III (34.0%) than low‐grade (3.3%) and intermediate‐grade MEC (8.1%; p < .001).
Conclusion
Grade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. © 2013 Wiley Periodicals, Inc. Head Neck 36: 158–163, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23765800</pmid><doi>10.1002/hed.23256</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2014-02, Vol.36 (2), p.158-163 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1490723006 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Carcinoma, Mucoepidermoid - epidemiology Carcinoma, Mucoepidermoid - pathology Carcinoma, Mucoepidermoid - radiotherapy Female Humans Incidence lymph node metastases Male Middle Aged mucoepidermoid carcinoma Neoplasm Grading parotid gland Parotid Neoplasms - epidemiology Parotid Neoplasms - pathology Parotid Neoplasms - radiotherapy Prognosis Risk Factors salivary gland carcinoma survival Treatment Outcome United States - epidemiology |
| title | Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A54%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histologic%20grade%20as%20prognostic%20indicator%20for%20mucoepidermoid%20carcinoma:%20A%20population-level%20analysis%20of%202400%20patients&rft.jtitle=Head%20&%20neck&rft.au=Chen,%20Michelle%20M.&rft.date=2014-02&rft.volume=36&rft.issue=2&rft.spage=158&rft.epage=163&rft.pages=158-163&rft.issn=1043-3074&rft.eissn=1097-0347&rft.coden=HEANEE&rft_id=info:doi/10.1002/hed.23256&rft_dat=%3Cproquest_cross%3E3177545331%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1476269965&rft_id=info:pmid/23765800&rfr_iscdi=true |