Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas
Background Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA...
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| Veröffentlicht in: | Head & neck 2014-02, Vol.36 (2), p.257-265 |
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| creator | Melkane, Antoine E. Auperin, Anne Saulnier, Patrick Lacroix, Ludovic Vielh, Philippe Casiraghi, Odile Msakni, Issam Drusch, Françoise Temam, Stéphane |
| description | Background
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load.
Methods
A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples.
Results
One hundred thirty‐three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty‐two lesions (92%) were localized to lymphoid areas. Sixty‐seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%).
Conclusion
HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor. © 2013 Wiley Periodicals, Inc. Head Neck 36: 257–265, 2014 |
| doi_str_mv | 10.1002/hed.23302 |
| format | Article |
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Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load.
Methods
A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples.
Results
One hundred thirty‐three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty‐two lesions (92%) were localized to lymphoid areas. Sixty‐seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%).
Conclusion
HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor. © 2013 Wiley Periodicals, Inc. Head Neck 36: 257–265, 2014</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23302</identifier><identifier>PMID: 23728782</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Carcinoma, Squamous Cell - virology ; Female ; Follow-Up Studies ; France - epidemiology ; human papillomavirus ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - isolation & purification ; Humans ; Incidence ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Oropharyngeal Neoplasms - epidemiology ; Oropharyngeal Neoplasms - pathology ; Oropharyngeal Neoplasms - therapy ; Oropharyngeal Neoplasms - virology ; oropharynx ; p16 ; Papillomavirus Infections - complications ; Prevalence ; Prognosis ; Prospective Studies ; quantitative polymerase chain reaction ; Retrospective Studies ; Risk Factors ; squamous cell carcinoma</subject><ispartof>Head & neck, 2014-02, Vol.36 (2), p.257-265</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3912-6def78b0cf0f7ddbf1be9420329d6cb25caa84302d86c050c39c9242377e1f2f3</citedby><cites>FETCH-LOGICAL-c3912-6def78b0cf0f7ddbf1be9420329d6cb25caa84302d86c050c39c9242377e1f2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23302$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23302$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23728782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melkane, Antoine E.</creatorcontrib><creatorcontrib>Auperin, Anne</creatorcontrib><creatorcontrib>Saulnier, Patrick</creatorcontrib><creatorcontrib>Lacroix, Ludovic</creatorcontrib><creatorcontrib>Vielh, Philippe</creatorcontrib><creatorcontrib>Casiraghi, Odile</creatorcontrib><creatorcontrib>Msakni, Issam</creatorcontrib><creatorcontrib>Drusch, Françoise</creatorcontrib><creatorcontrib>Temam, Stéphane</creatorcontrib><title>Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load.
Methods
A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples.
Results
One hundred thirty‐three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty‐two lesions (92%) were localized to lymphoid areas. Sixty‐seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%).
Conclusion
HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor. © 2013 Wiley Periodicals, Inc. Head Neck 36: 257–265, 2014</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>France - epidemiology</subject><subject>human papillomavirus</subject><subject>Human papillomavirus 16 - genetics</subject><subject>Human papillomavirus 16 - isolation & purification</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oropharyngeal Neoplasms - epidemiology</subject><subject>Oropharyngeal Neoplasms - pathology</subject><subject>Oropharyngeal Neoplasms - therapy</subject><subject>Oropharyngeal Neoplasms - virology</subject><subject>oropharynx</subject><subject>p16</subject><subject>Papillomavirus Infections - complications</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>quantitative polymerase chain reaction</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>squamous cell carcinoma</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtP3DAUhS3UqlDaBX-gitQNXQSuHxMnS95TaQSbIiQ2luM4YHDsYE9o-ffcYZguKnXlh75zdM4hZI_CAQVgh_e2O2CcA9siOxQaWQIX8sPqLnjJQYpt8jnnBwDglWCfyDbjktWyZjukm0-DDsWoR-d9HPSzS1MuxmSftbfB2EKHDp_xLsS8dKZww-id0UsXQ-FCEVMc73V6CXdW-yI_TXqIqDfW-8LoZFxAz_yFfOy1z_br-7lLrs_Pfp3My8XVxc-To0VpeENZWXW2l3ULpodedl3b09Y2ggFnTVeZls2M1rXAml1dGZgBqkzDBJaRlvas57tkf-2LgZ8mm5dqcHmVRQeLsRQVDUjGpABEv_-DPsQpBUyHlKyYxF1rpH6sKZNizsn2akxuwL6KglpNr3B69TY9st_eHad2wN8NudkagcM18Nt5-_J_JzU_O91YlmuFy0v7569Cp0dVSS5n6ubyQt3ezOj54hjUnL8C0hWdlA</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Melkane, Antoine E.</creator><creator>Auperin, Anne</creator><creator>Saulnier, Patrick</creator><creator>Lacroix, Ludovic</creator><creator>Vielh, Philippe</creator><creator>Casiraghi, Odile</creator><creator>Msakni, Issam</creator><creator>Drusch, Françoise</creator><creator>Temam, Stéphane</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas</title><author>Melkane, Antoine E. ; Auperin, Anne ; Saulnier, Patrick ; Lacroix, Ludovic ; Vielh, Philippe ; Casiraghi, Odile ; Msakni, Issam ; Drusch, Françoise ; Temam, Stéphane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3912-6def78b0cf0f7ddbf1be9420329d6cb25caa84302d86c050c39c9242377e1f2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>France - epidemiology</topic><topic>human papillomavirus</topic><topic>Human papillomavirus 16 - genetics</topic><topic>Human papillomavirus 16 - isolation & purification</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oropharyngeal Neoplasms - epidemiology</topic><topic>Oropharyngeal Neoplasms - pathology</topic><topic>Oropharyngeal Neoplasms - therapy</topic><topic>Oropharyngeal Neoplasms - virology</topic><topic>oropharynx</topic><topic>p16</topic><topic>Papillomavirus Infections - complications</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>quantitative polymerase chain reaction</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melkane, Antoine E.</creatorcontrib><creatorcontrib>Auperin, Anne</creatorcontrib><creatorcontrib>Saulnier, Patrick</creatorcontrib><creatorcontrib>Lacroix, Ludovic</creatorcontrib><creatorcontrib>Vielh, Philippe</creatorcontrib><creatorcontrib>Casiraghi, Odile</creatorcontrib><creatorcontrib>Msakni, Issam</creatorcontrib><creatorcontrib>Drusch, Françoise</creatorcontrib><creatorcontrib>Temam, Stéphane</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melkane, Antoine E.</au><au>Auperin, Anne</au><au>Saulnier, Patrick</au><au>Lacroix, Ludovic</au><au>Vielh, Philippe</au><au>Casiraghi, Odile</au><au>Msakni, Issam</au><au>Drusch, Françoise</au><au>Temam, Stéphane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-02</date><risdate>2014</risdate><volume>36</volume><issue>2</issue><spage>257</spage><epage>265</epage><pages>257-265</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load.
Methods
A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples.
Results
One hundred thirty‐three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty‐two lesions (92%) were localized to lymphoid areas. Sixty‐seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%).
Conclusion
HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor. © 2013 Wiley Periodicals, Inc. Head Neck 36: 257–265, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23728782</pmid><doi>10.1002/hed.23302</doi><tpages>9</tpages></addata></record> |
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| ispartof | Head & neck, 2014-02, Vol.36 (2), p.257-265 |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Carcinoma, Squamous Cell - virology Female Follow-Up Studies France - epidemiology human papillomavirus Human papillomavirus 16 - genetics Human papillomavirus 16 - isolation & purification Humans Incidence Kaplan-Meier Estimate Male Middle Aged Oropharyngeal Neoplasms - epidemiology Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - therapy Oropharyngeal Neoplasms - virology oropharynx p16 Papillomavirus Infections - complications Prevalence Prognosis Prospective Studies quantitative polymerase chain reaction Retrospective Studies Risk Factors squamous cell carcinoma |
| title | Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas |
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