Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model
In this study, coronary diagnostic parameters, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to distal dynamic pressure), and lesion flow coefficient (LFC: ratio of % area stenosis (%AS) to the CDP at throat region), were evaluated to distinguish levels of %AS under varying c...
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| Veröffentlicht in: | Heart and vessels 2014, Vol.29 (1), p.97-109 |
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| creator | Peelukhana, Srikara Viswanath Kolli, Kranthi K. Leesar, Massoud A. Effat, Mohamed A. Helmy, Tarek A. Arif, Imran Schneeberger, Eric W. Succop, Paul Banerjee, Rupak K. |
| description | In this study, coronary diagnostic parameters, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to distal dynamic pressure), and lesion flow coefficient (LFC: ratio of % area stenosis (%AS) to the CDP at throat region), were evaluated to distinguish levels of %AS under varying contractility conditions, in the presence of microvascular disease (MVD). In 10 pigs, %AS and MVD were created using angioplasty balloons and 90-μm microspheres, respectively. Simultaneous measurements of pressure drop, left ventricular pressure (
p
), and velocity were obtained. Contractility was calculated as (d
p
/d
t
)
max
, categorized into low contractility 900 mmHg/s, and in each group, compared between %AS 50 using analysis of variance. In the presence of MVD, between the %AS 50 groups, values of CDP (71 ± 1.4 and 121 ± 1.3) and LFC (0.10 ± 0.04 and 0.19 ± 0.04) were significantly different (
P
< 0.05), under low-contractility conditions. A similar %AS trend was observed under high-contractility conditions (CDP: 18 ± 1.4 and 91 ± 1.4; LFC: 0.08 ± 0.04 and 0.25 ± 0.04). Under MVD conditions, similar to fractional flow reserve, CDP and LFC were not influenced by contractility. |
| doi_str_mv | 10.1007/s00380-013-0355-9 |
| format | Article |
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p
), and velocity were obtained. Contractility was calculated as (d
p
/d
t
)
max
, categorized into low contractility <900 mmHg/s and high contractility >900 mmHg/s, and in each group, compared between %AS <50 and >50 using analysis of variance. In the presence of MVD, between the %AS <50 and >50 groups, values of CDP (71 ± 1.4 and 121 ± 1.3) and LFC (0.10 ± 0.04 and 0.19 ± 0.04) were significantly different (
P
< 0.05), under low-contractility conditions. A similar %AS trend was observed under high-contractility conditions (CDP: 18 ± 1.4 and 91 ± 1.4; LFC: 0.08 ± 0.04 and 0.25 ± 0.04). Under MVD conditions, similar to fractional flow reserve, CDP and LFC were not influenced by contractility.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-013-0355-9</identifier><identifier>PMID: 23624760</identifier><identifier>CODEN: HEVEEO</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Animals ; Biomedical Engineering and Bioengineering ; Blood Flow Velocity ; Cardiac Surgery ; Cardiology ; Cardiovascular disease ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - physiopathology ; Coronary Stenosis - diagnosis ; Coronary Stenosis - physiopathology ; Coronary Vessels - physiopathology ; Disease Models, Animal ; Fractional Flow Reserve, Myocardial ; Hemodynamics ; Hogs ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Microcirculation ; Myocardial Contraction ; Original Article ; Severity of Illness Index ; Swine ; Vascular Surgery ; Vein & artery diseases ; Ventricular Function, Left ; Ventricular Pressure</subject><ispartof>Heart and vessels, 2014, Vol.29 (1), p.97-109</ispartof><rights>Springer Japan 2013</rights><rights>Springer Japan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-3a735a9924eb7eec098c91830df2d270b20a9f09fc82f6f23e4c3011aee1d0a23</citedby><cites>FETCH-LOGICAL-c396t-3a735a9924eb7eec098c91830df2d270b20a9f09fc82f6f23e4c3011aee1d0a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-013-0355-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-013-0355-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23624760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peelukhana, Srikara Viswanath</creatorcontrib><creatorcontrib>Kolli, Kranthi K.</creatorcontrib><creatorcontrib>Leesar, Massoud A.</creatorcontrib><creatorcontrib>Effat, Mohamed A.</creatorcontrib><creatorcontrib>Helmy, Tarek A.</creatorcontrib><creatorcontrib>Arif, Imran</creatorcontrib><creatorcontrib>Schneeberger, Eric W.</creatorcontrib><creatorcontrib>Succop, Paul</creatorcontrib><creatorcontrib>Banerjee, Rupak K.</creatorcontrib><title>Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>In this study, coronary diagnostic parameters, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to distal dynamic pressure), and lesion flow coefficient (LFC: ratio of % area stenosis (%AS) to the CDP at throat region), were evaluated to distinguish levels of %AS under varying contractility conditions, in the presence of microvascular disease (MVD). In 10 pigs, %AS and MVD were created using angioplasty balloons and 90-μm microspheres, respectively. Simultaneous measurements of pressure drop, left ventricular pressure (
p
), and velocity were obtained. Contractility was calculated as (d
p
/d
t
)
max
, categorized into low contractility <900 mmHg/s and high contractility >900 mmHg/s, and in each group, compared between %AS <50 and >50 using analysis of variance. In the presence of MVD, between the %AS <50 and >50 groups, values of CDP (71 ± 1.4 and 121 ± 1.3) and LFC (0.10 ± 0.04 and 0.19 ± 0.04) were significantly different (
P
< 0.05), under low-contractility conditions. A similar %AS trend was observed under high-contractility conditions (CDP: 18 ± 1.4 and 91 ± 1.4; LFC: 0.08 ± 0.04 and 0.25 ± 0.04). Under MVD conditions, similar to fractional flow reserve, CDP and LFC were not influenced by contractility.</description><subject>Animals</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Blood Flow Velocity</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Stenosis - diagnosis</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Coronary Vessels - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Fractional Flow Reserve, Myocardial</subject><subject>Hemodynamics</subject><subject>Hogs</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microcirculation</subject><subject>Myocardial Contraction</subject><subject>Original Article</subject><subject>Severity of Illness Index</subject><subject>Swine</subject><subject>Vascular Surgery</subject><subject>Vein & artery diseases</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Pressure</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kcFqFTEUhoMo9rb6AG4k4MbN1JNkZjJZSqm2UHCj65CbnGjKTHJNMi337c3l1lIKXWVxvv8_OXyEfGBwzgDklwIgJuiAiQ7EMHTqFdmwkQ0dH6R4TTagGHST4PKEnJZyC8AGxdRbcsLFyHs5wobcX3qPttLk6bJP1mQXzExtijUbW8Mc6p6mSP_gktw-miVYitHRXQqxFrpGh_lA27SEamKlDcjpzhS7ziZTFwqagjREalom2xCRtiac35E33swF3z-8Z-TXt8ufF1fdzY_v1xdfbzor1Fg7YaQYjFK8x61EtKAmq9gkwHnuuIQtB6M8KG8n7kfPBfZWAGMGkTkwXJyRz8feXU5_VyxVL6FYnGcTMa1Fs16B5Hzs-4Z-eobepjXH9rtGyZEPSvayUexItTtLyej1LofF5L1moA9W9NGKblb0wYpWLfPxoXndLugeE_81NIAfgdJG8TfmJ6tfbP0HJSSZEA</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Peelukhana, Srikara Viswanath</creator><creator>Kolli, Kranthi K.</creator><creator>Leesar, Massoud A.</creator><creator>Effat, Mohamed A.</creator><creator>Helmy, Tarek A.</creator><creator>Arif, Imran</creator><creator>Schneeberger, Eric W.</creator><creator>Succop, Paul</creator><creator>Banerjee, Rupak K.</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model</title><author>Peelukhana, Srikara Viswanath ; Kolli, Kranthi K. ; Leesar, Massoud A. ; Effat, Mohamed A. ; Helmy, Tarek A. ; Arif, Imran ; Schneeberger, Eric W. ; Succop, Paul ; Banerjee, Rupak K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-3a735a9924eb7eec098c91830df2d270b20a9f09fc82f6f23e4c3011aee1d0a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Blood Flow Velocity</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Stenosis - diagnosis</topic><topic>Coronary Stenosis - physiopathology</topic><topic>Coronary Vessels - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Fractional Flow Reserve, Myocardial</topic><topic>Hemodynamics</topic><topic>Hogs</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microcirculation</topic><topic>Myocardial Contraction</topic><topic>Original Article</topic><topic>Severity of Illness Index</topic><topic>Swine</topic><topic>Vascular Surgery</topic><topic>Vein & artery diseases</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peelukhana, Srikara Viswanath</creatorcontrib><creatorcontrib>Kolli, Kranthi K.</creatorcontrib><creatorcontrib>Leesar, Massoud A.</creatorcontrib><creatorcontrib>Effat, Mohamed A.</creatorcontrib><creatorcontrib>Helmy, Tarek A.</creatorcontrib><creatorcontrib>Arif, Imran</creatorcontrib><creatorcontrib>Schneeberger, Eric W.</creatorcontrib><creatorcontrib>Succop, Paul</creatorcontrib><creatorcontrib>Banerjee, Rupak K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peelukhana, Srikara Viswanath</au><au>Kolli, Kranthi K.</au><au>Leesar, Massoud A.</au><au>Effat, Mohamed A.</au><au>Helmy, Tarek A.</au><au>Arif, Imran</au><au>Schneeberger, Eric W.</au><au>Succop, Paul</au><au>Banerjee, Rupak K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2014</date><risdate>2014</risdate><volume>29</volume><issue>1</issue><spage>97</spage><epage>109</epage><pages>97-109</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><coden>HEVEEO</coden><abstract>In this study, coronary diagnostic parameters, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to distal dynamic pressure), and lesion flow coefficient (LFC: ratio of % area stenosis (%AS) to the CDP at throat region), were evaluated to distinguish levels of %AS under varying contractility conditions, in the presence of microvascular disease (MVD). In 10 pigs, %AS and MVD were created using angioplasty balloons and 90-μm microspheres, respectively. Simultaneous measurements of pressure drop, left ventricular pressure (
p
), and velocity were obtained. Contractility was calculated as (d
p
/d
t
)
max
, categorized into low contractility <900 mmHg/s and high contractility >900 mmHg/s, and in each group, compared between %AS <50 and >50 using analysis of variance. In the presence of MVD, between the %AS <50 and >50 groups, values of CDP (71 ± 1.4 and 121 ± 1.3) and LFC (0.10 ± 0.04 and 0.19 ± 0.04) were significantly different (
P
< 0.05), under low-contractility conditions. A similar %AS trend was observed under high-contractility conditions (CDP: 18 ± 1.4 and 91 ± 1.4; LFC: 0.08 ± 0.04 and 0.25 ± 0.04). Under MVD conditions, similar to fractional flow reserve, CDP and LFC were not influenced by contractility.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>23624760</pmid><doi>10.1007/s00380-013-0355-9</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Biomedical Engineering and Bioengineering Blood Flow Velocity Cardiac Surgery Cardiology Cardiovascular disease Coronary Artery Disease - diagnosis Coronary Artery Disease - physiopathology Coronary Stenosis - diagnosis Coronary Stenosis - physiopathology Coronary Vessels - physiopathology Disease Models, Animal Fractional Flow Reserve, Myocardial Hemodynamics Hogs Medical diagnosis Medicine Medicine & Public Health Microcirculation Myocardial Contraction Original Article Severity of Illness Index Swine Vascular Surgery Vein & artery diseases Ventricular Function, Left Ventricular Pressure |
| title | Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model |
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