A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression

Melanogenesis is essential for the protection of skin against UV, but excessive production of melanin causes unaesthetic hyperpigmentation. Much effort is being made to develop effective depigmenting agents. Here, we found that a tyrosinase inhibitor, AP736 (5‐adamantan‐1‐yl‐N‐(2,4‐dihydroxy‐benzyl)...

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Veröffentlicht in:	Experimental dermatology 2013-11, Vol.22 (11), p.762-764
Hauptverfasser:	Lee, Chang Seok, Jang, Won-Hee, Park, Miyoung, Jung, Kyoungmi, Baek, Heung Soo, Joo, Yung Hyup, Park, Young-Ho, Lim, Kyung-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - chemistry Animals Benzamides - chemistry cAMP response element-binding protein Cell Line, Tumor Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Gene Expression Regulation Humans Hyperpigmentation - metabolism Melanins - chemistry melanocyte Melanocytes - cytology melanogenesis Melanoma, Experimental - metabolism Mice microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - antagonists & inhibitors Monophenol Monooxygenase - antagonists & inhibitors Signal Transduction Skin - pathology Skin Neoplasms - metabolism tyrosinase
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