Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events

Human autopsy, animal, and cell culture studies together have merged in a concept suggesting participation of mast cells (MCs) in the generation of atherosclerotic plaques. More specifically, these studies have suggested MC-induced intraplaque neovascularization as one mechanism by which MCs may ren...

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Veröffentlicht in:	European heart journal 2013-12, Vol.34 (48), p.3699-3706
Hauptverfasser:	Willems, Sanne, Vink, Aryan, Bot, Ilze, Quax, Paul H A, de Borst, Gert Jan, de Vries, Jean-Paul P M, van de Weg, Sander M, Moll, Frans L, Kuiper, Johan, Kovanen, Petri T, de Kleijn, Dominique P V, Hoefer, Imo E, Pasterkamp, Gerard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cardiovascular Diseases - etiology Cardiovascular Diseases - pathology Carotid Stenosis - pathology Carotid Stenosis - physiopathology Carotid Stenosis - surgery Case-Control Studies Endarterectomy, Carotid Female Follow-Up Studies Humans Immunohistochemistry Male Mast Cells - enzymology Mast Cells - pathology Microvessels - pathology Neovascularization, Pathologic - pathology Plaque, Atherosclerotic - pathology Plaque, Atherosclerotic - physiopathology Plaque, Atherosclerotic - surgery Postoperative Complications - etiology Postoperative Complications - pathology Treatment Outcome Tryptases - metabolism
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