Cellular response to orthodontically-induced short-term hypoxia in dental pulp cells
Orthodontic force application is well known to induce sterile inflammation, which is initially caused by the compression of blood vessels in tooth-supporting apparatus. The reaction of periodontal ligament cells to mechanical loading has been thoroughly investigated, whereas knowledge on tissue reac...
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| Veröffentlicht in: | Cell and tissue research 2014-01, Vol.355 (1), p.173-180 |
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| creator | Römer, Piero Wolf, Michael Fanghänel, Jochen Reicheneder, Claudia Proff, Peter |
| description | Orthodontic force application is well known to induce sterile inflammation, which is initially caused by the compression of blood vessels in tooth-supporting apparatus. The reaction of periodontal ligament cells to mechanical loading has been thoroughly investigated, whereas knowledge on tissue reactions of the dental pulp is rather limited. The aim of the present trial is to analyze the effect of orthodontic treatment on the induction and cellular regulation of intra-pulpal hypoxia. To investigate the effect of orthodontic force on dental pulp cells, which results in circulatory disturbances within the dental pulp, we used a rat model for the immunohistochemical analysis of the accumulation of hypoxia-inducible factor-1α in the initial phase of orthodontic tooth movement. To further examine the regulatory role of circulatory disturbances and hypoxic conditions, we analyze isolated dental pulp cells from human teeth with regard to their specific reaction under hypoxic conditions by means of flow cytometry, immunoblot, ELISA and real-time PCR on markers (Hif-1α, VEGF, Cox-2, IL-6, IL-8, ROS, p65). In vivo experiments showed the induction of hypoxia in dental pulp after orthodontic tooth movement. The induction of oxidative stress in human dental pulp cells showed up-regulation of the pro-inflammatory and angiogenic genes Cox-2, VEGF, IL-6 and IL-8. The present data suggest that orthodontic tooth movement affects dental pulp circulation by hypoxia, which leads to an inflammatory response inside treated teeth. Therefore, pulp tissue may be expected to undergo a remodeling process after tooth movement. |
| doi_str_mv | 10.1007/s00441-013-1739-y |
| format | Article |
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The reaction of periodontal ligament cells to mechanical loading has been thoroughly investigated, whereas knowledge on tissue reactions of the dental pulp is rather limited. The aim of the present trial is to analyze the effect of orthodontic treatment on the induction and cellular regulation of intra-pulpal hypoxia. To investigate the effect of orthodontic force on dental pulp cells, which results in circulatory disturbances within the dental pulp, we used a rat model for the immunohistochemical analysis of the accumulation of hypoxia-inducible factor-1α in the initial phase of orthodontic tooth movement. To further examine the regulatory role of circulatory disturbances and hypoxic conditions, we analyze isolated dental pulp cells from human teeth with regard to their specific reaction under hypoxic conditions by means of flow cytometry, immunoblot, ELISA and real-time PCR on markers (Hif-1α, VEGF, Cox-2, IL-6, IL-8, ROS, p65). In vivo experiments showed the induction of hypoxia in dental pulp after orthodontic tooth movement. The induction of oxidative stress in human dental pulp cells showed up-regulation of the pro-inflammatory and angiogenic genes Cox-2, VEGF, IL-6 and IL-8. The present data suggest that orthodontic tooth movement affects dental pulp circulation by hypoxia, which leads to an inflammatory response inside treated teeth. Therefore, pulp tissue may be expected to undergo a remodeling process after tooth movement.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-013-1739-y</identifier><identifier>PMID: 24192938</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; anaerobic conditions ; Analysis ; animal models ; Animals ; Biomedical and Life Sciences ; Biomedicine ; blood vessels ; Cell Hypoxia ; Cells ; Cells, Cultured ; Cellular biology ; Cytokines - analysis ; Dental care ; Dental Pulp - blood supply ; Dental Pulp - cytology ; Dental Pulp - metabolism ; enzyme-linked immunosorbent assay ; flow cytometry ; gene expression regulation ; genes ; Human Genetics ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit - analysis ; immunohistochemistry ; in vivo studies ; Inflammation ; interleukin-6 ; interleukin-8 ; ligaments ; Male ; Molecular Medicine ; Orthodontics ; Oxidative Stress ; Oxygen - metabolism ; Proteomics ; pulp ; quantitative polymerase chain reaction ; Rats ; Rats, Wistar ; Regular Article ; Teeth ; Tooth Movement Techniques ; tooth pulp ; Vascular endothelial growth factor ; Young Adult</subject><ispartof>Cell and tissue research, 2014-01, Vol.355 (1), p.173-180</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>COPYRIGHT 2014 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-23f6ad55b2e03e141792effbb03139e219cd56b524a1bc91bb5d86fc423710f33</citedby><cites>FETCH-LOGICAL-c560t-23f6ad55b2e03e141792effbb03139e219cd56b524a1bc91bb5d86fc423710f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-013-1739-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-013-1739-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24192938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Römer, Piero</creatorcontrib><creatorcontrib>Wolf, Michael</creatorcontrib><creatorcontrib>Fanghänel, Jochen</creatorcontrib><creatorcontrib>Reicheneder, Claudia</creatorcontrib><creatorcontrib>Proff, Peter</creatorcontrib><title>Cellular response to orthodontically-induced short-term hypoxia in dental pulp cells</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Orthodontic force application is well known to induce sterile inflammation, which is initially caused by the compression of blood vessels in tooth-supporting apparatus. The reaction of periodontal ligament cells to mechanical loading has been thoroughly investigated, whereas knowledge on tissue reactions of the dental pulp is rather limited. The aim of the present trial is to analyze the effect of orthodontic treatment on the induction and cellular regulation of intra-pulpal hypoxia. To investigate the effect of orthodontic force on dental pulp cells, which results in circulatory disturbances within the dental pulp, we used a rat model for the immunohistochemical analysis of the accumulation of hypoxia-inducible factor-1α in the initial phase of orthodontic tooth movement. To further examine the regulatory role of circulatory disturbances and hypoxic conditions, we analyze isolated dental pulp cells from human teeth with regard to their specific reaction under hypoxic conditions by means of flow cytometry, immunoblot, ELISA and real-time PCR on markers (Hif-1α, VEGF, Cox-2, IL-6, IL-8, ROS, p65). In vivo experiments showed the induction of hypoxia in dental pulp after orthodontic tooth movement. The induction of oxidative stress in human dental pulp cells showed up-regulation of the pro-inflammatory and angiogenic genes Cox-2, VEGF, IL-6 and IL-8. The present data suggest that orthodontic tooth movement affects dental pulp circulation by hypoxia, which leads to an inflammatory response inside treated teeth. Therefore, pulp tissue may be expected to undergo a remodeling process after tooth movement.</description><subject>Adult</subject><subject>anaerobic conditions</subject><subject>Analysis</subject><subject>animal models</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>blood vessels</subject><subject>Cell Hypoxia</subject><subject>Cells</subject><subject>Cells, Cultured</subject><subject>Cellular biology</subject><subject>Cytokines - analysis</subject><subject>Dental care</subject><subject>Dental Pulp - blood supply</subject><subject>Dental Pulp - cytology</subject><subject>Dental Pulp - metabolism</subject><subject>enzyme-linked immunosorbent assay</subject><subject>flow cytometry</subject><subject>gene expression regulation</subject><subject>genes</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - analysis</subject><subject>immunohistochemistry</subject><subject>in vivo studies</subject><subject>Inflammation</subject><subject>interleukin-6</subject><subject>interleukin-8</subject><subject>ligaments</subject><subject>Male</subject><subject>Molecular Medicine</subject><subject>Orthodontics</subject><subject>Oxidative Stress</subject><subject>Oxygen - metabolism</subject><subject>Proteomics</subject><subject>pulp</subject><subject>quantitative polymerase chain reaction</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regular Article</subject><subject>Teeth</subject><subject>Tooth Movement Techniques</subject><subject>tooth pulp</subject><subject>Vascular endothelial growth factor</subject><subject>Young Adult</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kl2L1TAQhoso7nH1B3ijBWHxJms-m-ZyObgqLHjhLngX0nZ6miUnqUkL9t-b0lXOikguApnnnczMO0XxmuBLgrH8kDDmnCBMGCKSKbQ8KXaEM4pwLeunxQ4zTJGsqu9nxYuU7jEmvKrU8-KMcqKoYvWuuN2Dc7MzsYyQxuATlFMoQ5yG0AU_2dY4tyDru7mFrkxDjqAJ4rEcljH8tKa0vuzAT8aV4-zGss3p0sviWW9cglcP93lxd_3xdv8Z3Xz99GV_dYNaUeEJUdZXphOioYAZEE6kotD3TYMZYQooUW0nqkZQbkjTKtI0oqurvuWUSYJ7xs6L91veMYYfM6RJH21aKzAewpw04QpLIqSQGX33F3of5uhzdZmSAlPJ6Ql1MA609X2YomnXpPqKCaVUzfj67eU_qHw6ONo2eOhtfn8kuDgRDGDcNKTg5snmgT8GyQa2MaQUoddjtEcTF02wXi3Xm-U6W65Xy_WSNW8eOpubI3R_FL89zgDdgJRD_gDxpPX_ZH27iXoTtDlEm_TdN5oXKC8Ry-Ov2S9Drr3w</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Römer, Piero</creator><creator>Wolf, Michael</creator><creator>Fanghänel, Jochen</creator><creator>Reicheneder, Claudia</creator><creator>Proff, Peter</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Cellular response to orthodontically-induced short-term hypoxia in dental pulp cells</title><author>Römer, Piero ; Wolf, Michael ; Fanghänel, Jochen ; Reicheneder, Claudia ; Proff, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-23f6ad55b2e03e141792effbb03139e219cd56b524a1bc91bb5d86fc423710f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>anaerobic conditions</topic><topic>Analysis</topic><topic>animal models</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>blood vessels</topic><topic>Cell Hypoxia</topic><topic>Cells</topic><topic>Cells, Cultured</topic><topic>Cellular biology</topic><topic>Cytokines - 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Academic</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Römer, Piero</au><au>Wolf, Michael</au><au>Fanghänel, Jochen</au><au>Reicheneder, Claudia</au><au>Proff, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular response to orthodontically-induced short-term hypoxia in dental pulp cells</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>355</volume><issue>1</issue><spage>173</spage><epage>180</epage><pages>173-180</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>Orthodontic force application is well known to induce sterile inflammation, which is initially caused by the compression of blood vessels in tooth-supporting apparatus. The reaction of periodontal ligament cells to mechanical loading has been thoroughly investigated, whereas knowledge on tissue reactions of the dental pulp is rather limited. The aim of the present trial is to analyze the effect of orthodontic treatment on the induction and cellular regulation of intra-pulpal hypoxia. To investigate the effect of orthodontic force on dental pulp cells, which results in circulatory disturbances within the dental pulp, we used a rat model for the immunohistochemical analysis of the accumulation of hypoxia-inducible factor-1α in the initial phase of orthodontic tooth movement. To further examine the regulatory role of circulatory disturbances and hypoxic conditions, we analyze isolated dental pulp cells from human teeth with regard to their specific reaction under hypoxic conditions by means of flow cytometry, immunoblot, ELISA and real-time PCR on markers (Hif-1α, VEGF, Cox-2, IL-6, IL-8, ROS, p65). In vivo experiments showed the induction of hypoxia in dental pulp after orthodontic tooth movement. The induction of oxidative stress in human dental pulp cells showed up-regulation of the pro-inflammatory and angiogenic genes Cox-2, VEGF, IL-6 and IL-8. The present data suggest that orthodontic tooth movement affects dental pulp circulation by hypoxia, which leads to an inflammatory response inside treated teeth. Therefore, pulp tissue may be expected to undergo a remodeling process after tooth movement.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>24192938</pmid><doi>10.1007/s00441-013-1739-y</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult anaerobic conditions Analysis animal models Animals Biomedical and Life Sciences Biomedicine blood vessels Cell Hypoxia Cells Cells, Cultured Cellular biology Cytokines - analysis Dental care Dental Pulp - blood supply Dental Pulp - cytology Dental Pulp - metabolism enzyme-linked immunosorbent assay flow cytometry gene expression regulation genes Human Genetics Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - analysis immunohistochemistry in vivo studies Inflammation interleukin-6 interleukin-8 ligaments Male Molecular Medicine Orthodontics Oxidative Stress Oxygen - metabolism Proteomics pulp quantitative polymerase chain reaction Rats Rats, Wistar Regular Article Teeth Tooth Movement Techniques tooth pulp Vascular endothelial growth factor Young Adult |
| title | Cellular response to orthodontically-induced short-term hypoxia in dental pulp cells |
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