Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

ABSTRACT The drug development industry faces multiple challenges in the realization of safe effective drugs. Computational modeling approaches can be used to support these efforts. One approach, mechanistic modeling, is new to the realm of drug safety. It holds the promise of not only predicting tox...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2014-01, Vol.35 (1), p.33-49
Hauptverfasser:	Shoda, Lisl K. M., Woodhead, Jeffrey L., Siler, Scott Q., Watkins, Paul B., Howell, Brett A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Chemical and Drug Induced Liver Injury computational models drug safety drug-induced liver injury hepatotoxicity Humans Immunity, Innate mechanistic models Mitochondria - physiology Models, Biological Software
Online-Zugang:	Volltext
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