Therapeutic Effects of Gel Ointments Containing Tranilast Nanoparticles on Paw Edema in Adjuvant-Induced Arthritis Rats

Tranilast (TL), an antiallergic agent, has been clinically used in the treatment of bronchial asthma, although its clinical use has been limited by its poor solubility in water, photodegradation and systemic side effects. In this study, we prepared a gel ointment containing TL nanoparticles (TLnano...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 2014/01/01, Vol.37(1), pp.96-104
Hauptverfasser:	Nagai, Noriaki, Ito, Yoshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Acrylates - administration & dosage adjuvant-induced arthritis Administration, Cutaneous Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacokinetics Anti-Inflammatory Agents - therapeutic use Arthritis, Experimental - drug therapy Arthritis, Experimental - pathology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - pathology beta-Cyclodextrins - administration & dosage Edema - drug therapy Gels Inflammation - drug therapy Inflammation - pathology Male Methylcellulose - administration & dosage nanoparticle Nanoparticles nanotechnology Ointments ortho-Aminobenzoates - administration & dosage ortho-Aminobenzoates - metabolism ortho-Aminobenzoates - pharmacokinetics ortho-Aminobenzoates - therapeutic use Particle Size Rats Rats, Wistar Skin - metabolism Skin Absorption Solubility Tranilast transdermal therapeutic system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!