Wound contraction decreases with intravenously injected substance P in rabbits
Abstract Substance P is an injury-inducible endogenous factor for the mobilization of CD29+ stromal-like cells into circulation and that are major effectors of accelerated healing. In this study, we evaluated the effect of intravenously injected substance P on full-thickness skin wound healing as a...
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| Veröffentlicht in: | Burns 2014-02, Vol.40 (1), p.127-134 |
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| creator | Lee, Jun Yong Kim, Woo Seob Kim, Wonyong Kim, Han Koo Bae, Tae Hui Park, Jeong Ae |
| description | Abstract Substance P is an injury-inducible endogenous factor for the mobilization of CD29+ stromal-like cells into circulation and that are major effectors of accelerated healing. In this study, we evaluated the effect of intravenously injected substance P on full-thickness skin wound healing as a secondary intention wound model. We made circular full-thickness skin wounds on the ears of 28 New Zealand white rabbits. They were treated with phosphate-buffered saline, or intravenous 5, 50, or 250 nmole/kg substance P at days 0 and 1. All substance P-treated groups showed a 2.6–5.4-fold higher CD29 expression and resulted in greatly decreased wound contraction and early maturation of the stroma. However, a significant decrease in wound contraction was measured only in the 5 nmole/kg treatment group. We conclude that intravenously injected substance P at 5 nmole/kg decreases wound contraction and promotes wound maturation in full-thickness skin wounds in a rabbit ear model. |
| doi_str_mv | 10.1016/j.burns.2013.06.008 |
| format | Article |
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In this study, we evaluated the effect of intravenously injected substance P on full-thickness skin wound healing as a secondary intention wound model. We made circular full-thickness skin wounds on the ears of 28 New Zealand white rabbits. They were treated with phosphate-buffered saline, or intravenous 5, 50, or 250 nmole/kg substance P at days 0 and 1. All substance P-treated groups showed a 2.6–5.4-fold higher CD29 expression and resulted in greatly decreased wound contraction and early maturation of the stroma. However, a significant decrease in wound contraction was measured only in the 5 nmole/kg treatment group. We conclude that intravenously injected substance P at 5 nmole/kg decreases wound contraction and promotes wound maturation in full-thickness skin wounds in a rabbit ear model.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/j.burns.2013.06.008</identifier><identifier>PMID: 23972945</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; CD29 ; Critical Care ; Disease Models, Animal ; Ear - injuries ; Injections, Intravenous ; Integrin beta1 - drug effects ; Integrin beta1 - metabolism ; Rabbits ; Skin - cytology ; Skin - drug effects ; Skin - injuries ; Stromal Cells - drug effects ; Stromal Cells - metabolism ; Substance P ; Substance P - pharmacology ; Wound contraction ; Wound healing ; Wound Healing - drug effects ; Wounds and Injuries - metabolism ; Wounds and Injuries - physiopathology</subject><ispartof>Burns, 2014-02, Vol.40 (1), p.127-134</ispartof><rights>2013</rights><rights>Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-f918020f8bbb31084acbc1f834c12bc140e7e8caa4e0f3fa7f09687e6048c0473</citedby><cites>FETCH-LOGICAL-c414t-f918020f8bbb31084acbc1f834c12bc140e7e8caa4e0f3fa7f09687e6048c0473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.burns.2013.06.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23972945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jun Yong</creatorcontrib><creatorcontrib>Kim, Woo Seob</creatorcontrib><creatorcontrib>Kim, Wonyong</creatorcontrib><creatorcontrib>Kim, Han Koo</creatorcontrib><creatorcontrib>Bae, Tae Hui</creatorcontrib><creatorcontrib>Park, Jeong Ae</creatorcontrib><title>Wound contraction decreases with intravenously injected substance P in rabbits</title><title>Burns</title><addtitle>Burns</addtitle><description>Abstract Substance P is an injury-inducible endogenous factor for the mobilization of CD29+ stromal-like cells into circulation and that are major effectors of accelerated healing. In this study, we evaluated the effect of intravenously injected substance P on full-thickness skin wound healing as a secondary intention wound model. We made circular full-thickness skin wounds on the ears of 28 New Zealand white rabbits. They were treated with phosphate-buffered saline, or intravenous 5, 50, or 250 nmole/kg substance P at days 0 and 1. All substance P-treated groups showed a 2.6–5.4-fold higher CD29 expression and resulted in greatly decreased wound contraction and early maturation of the stroma. However, a significant decrease in wound contraction was measured only in the 5 nmole/kg treatment group. We conclude that intravenously injected substance P at 5 nmole/kg decreases wound contraction and promotes wound maturation in full-thickness skin wounds in a rabbit ear model.</description><subject>Animals</subject><subject>CD29</subject><subject>Critical Care</subject><subject>Disease Models, Animal</subject><subject>Ear - injuries</subject><subject>Injections, Intravenous</subject><subject>Integrin beta1 - drug effects</subject><subject>Integrin beta1 - metabolism</subject><subject>Rabbits</subject><subject>Skin - cytology</subject><subject>Skin - drug effects</subject><subject>Skin - injuries</subject><subject>Stromal Cells - drug effects</subject><subject>Stromal Cells - metabolism</subject><subject>Substance P</subject><subject>Substance P - pharmacology</subject><subject>Wound contraction</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wounds and Injuries - metabolism</subject><subject>Wounds and Injuries - physiopathology</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotvCEyChHLkkzMTexD6AhCqgSBUgAeJo2c5EOGST4kmK9u1x2MKBC77YHv-_Z-YbIZ4gVAjYPB8qv6aJqxpQVtBUAPqe2KFuTYkKzH2xAwn7UmFrzsQ58wB57TU8FGe1NG1t1H4n3n-d16krwjwtyYUlzlPRUUjkmLj4GZdvRdxebmmaVx6P-TZQWKgrePW8uClQ8TEHi-S8jws_Eg96NzI9vtsvxJc3rz9fXpXXH96-u3x1XQaFail7gxpq6LX3XiJo5YIP2GupAtb5pIBa0sE5RdDL3rU9mEa31IDSAVQrL8Sz0783af6xEi_2EDnQOLqJcqEWlYEWTG49S-VJGtLMnKi3NykeXDpaBLuBtIP9DdJuIC00NoPMrqd3CVZ_oO6v5w-5LHhxElBu8zZSshwiZR5dTJmQ7eb4nwQv__GHMU4xuPE7HYmHOTsyQYuWawv20zbLbZQoAdCAlL8AgZabAQ</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Lee, Jun Yong</creator><creator>Kim, Woo Seob</creator><creator>Kim, Wonyong</creator><creator>Kim, Han Koo</creator><creator>Bae, Tae Hui</creator><creator>Park, Jeong Ae</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Wound contraction decreases with intravenously injected substance P in rabbits</title><author>Lee, Jun Yong ; Kim, Woo Seob ; Kim, Wonyong ; Kim, Han Koo ; Bae, Tae Hui ; Park, Jeong Ae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-f918020f8bbb31084acbc1f834c12bc140e7e8caa4e0f3fa7f09687e6048c0473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>CD29</topic><topic>Critical Care</topic><topic>Disease Models, Animal</topic><topic>Ear - injuries</topic><topic>Injections, Intravenous</topic><topic>Integrin beta1 - drug effects</topic><topic>Integrin beta1 - metabolism</topic><topic>Rabbits</topic><topic>Skin - cytology</topic><topic>Skin - drug effects</topic><topic>Skin - injuries</topic><topic>Stromal Cells - drug effects</topic><topic>Stromal Cells - metabolism</topic><topic>Substance P</topic><topic>Substance P - pharmacology</topic><topic>Wound contraction</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wounds and Injuries - metabolism</topic><topic>Wounds and Injuries - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jun Yong</creatorcontrib><creatorcontrib>Kim, Woo Seob</creatorcontrib><creatorcontrib>Kim, Wonyong</creatorcontrib><creatorcontrib>Kim, Han Koo</creatorcontrib><creatorcontrib>Bae, Tae Hui</creatorcontrib><creatorcontrib>Park, Jeong Ae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jun Yong</au><au>Kim, Woo Seob</au><au>Kim, Wonyong</au><au>Kim, Han Koo</au><au>Bae, Tae Hui</au><au>Park, Jeong Ae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wound contraction decreases with intravenously injected substance P in rabbits</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>40</volume><issue>1</issue><spage>127</spage><epage>134</epage><pages>127-134</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><abstract>Abstract Substance P is an injury-inducible endogenous factor for the mobilization of CD29+ stromal-like cells into circulation and that are major effectors of accelerated healing. In this study, we evaluated the effect of intravenously injected substance P on full-thickness skin wound healing as a secondary intention wound model. We made circular full-thickness skin wounds on the ears of 28 New Zealand white rabbits. They were treated with phosphate-buffered saline, or intravenous 5, 50, or 250 nmole/kg substance P at days 0 and 1. All substance P-treated groups showed a 2.6–5.4-fold higher CD29 expression and resulted in greatly decreased wound contraction and early maturation of the stroma. However, a significant decrease in wound contraction was measured only in the 5 nmole/kg treatment group. We conclude that intravenously injected substance P at 5 nmole/kg decreases wound contraction and promotes wound maturation in full-thickness skin wounds in a rabbit ear model.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>23972945</pmid><doi>10.1016/j.burns.2013.06.008</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals CD29 Critical Care Disease Models, Animal Ear - injuries Injections, Intravenous Integrin beta1 - drug effects Integrin beta1 - metabolism Rabbits Skin - cytology Skin - drug effects Skin - injuries Stromal Cells - drug effects Stromal Cells - metabolism Substance P Substance P - pharmacology Wound contraction Wound healing Wound Healing - drug effects Wounds and Injuries - metabolism Wounds and Injuries - physiopathology |
| title | Wound contraction decreases with intravenously injected substance P in rabbits |
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