ent-Kaurane and ent-Pimarane Diterpenes from Siegesbeckia pubescens Inhibit Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia

The extract of Siegesbeckia pubescens herb and its chemical constituents were tested for the ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglia. The methanol extract and the 90% MeOH fraction of S. pubescens effectively attenuated lipopolysaccharide-ind...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2014/01/01, Vol.37(1), pp.152-157
Hauptverfasser:	Lee, Mina, Kim, Seung Hyun, Lee, Hee Kyoung, Cho, Yekyung, Kang, Jimmy, Sung, Sang Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Asteraceae - chemistry BV2 microglia cell Cyclooxygenase 2 - metabolism Diterpenes, Abietane - pharmacology Diterpenes, Abietane - therapeutic use Diterpenes, Kaurane - pharmacology Diterpenes, Kaurane - therapeutic use diterpenoid Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Lipopolysaccharides Mice Microglia - drug effects Microglia - metabolism nitric oxide (NO) Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - metabolism Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Siegesbeckia pubescens
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