Association of loss of heterozygosity with shorter survival in primary glioblastoma patients

Loss of heterozygosity (LOH) co-deletion 1p/19q, MGMT promoter methylation and/or IDH1 mutation generally signify a better prognosis for patients with glioma. However, the influence of 1p/19q co-deletion and the LOH on other chromosomes in primary glioblastoma on survival is still debatable. The aim...

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Veröffentlicht in:	Polish journal of pathology 2013-12, Vol.64 (4), p.268-275
Hauptverfasser:	Jesionek-Kupnicka, D, Szybka, M, Potemski, P, Kulczycka-Wojdala, D, Jaskólski, D, Bieńkowski, M, Skowroński, W, Papierz, W, Kordek, R, Zawlik, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Brain cancer Chemotherapy Chromosome Deletion Chromosomes Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 19 - genetics Deoxyribonucleic acid DNA DNA methylation DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Female Glioblastoma - genetics Glioblastoma - mortality Humans Isocitrate Dehydrogenase - genetics Kaplan-Meier Estimate Loss of Heterozygosity - genetics Male Medical prognosis Middle Aged Mutation Mutation, Missense Prognosis Radiation therapy Receptor, Epidermal Growth Factor - genetics Sequence Analysis, DNA Sequence Deletion Surgery Tumor Suppressor Protein p53 - genetics Tumors Young Adult
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