A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signaling

Purpose We investigated the action mechanism of a novel anticancer compound, KR28 (1-allyl-4-dodecanoyl-1-ethyl-piperazin-1-ium; bromide), to induce apoptosis of human prostate carcinoma PC-3 cells. Methods To explore an apoptotic signaling of KR28, we used ROS assay, SRB assay, flow cytometry analy...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2013-12, Vol.72 (6), p.1315-1324
Hauptverfasser:	Chung, Kyung-Sook, Han, Gyoonhee, Kim, Bo-Kyung, Kim, Hwan-Mook, Yang, Jee Sun, Ahn, Jiwon, Lee, Kyeong, Song, Kyung-Bin, Won, Misun
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds - pharmacology Animals Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Blotting, Western Cancer Research Cell Line, Tumor Female Flow Cytometry Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - drug therapy Neoplasms - pathology Nephrology. Urinary tract diseases Oncology Original Article p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Pharmacology/Toxicology Piperazines - pharmacology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-abl - metabolism Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction rhoB GTP-Binding Protein - genetics Signal Transduction - drug effects Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Tumors Tumors of the urinary system Up-Regulation - drug effects Urinary tract. Prostate gland Xenograft Model Antitumor Assays
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