Conditioned rewarding effects of morphine and methadone in mice pre-exposed to cocaine

Methadone is widely accepted as the most effective treatment of opioid dependence. However, clinical observations indicate that the medication is less effective in individuals abusing cocaine. Diminished therapeutic efficacy of methadone in cocaine users is intriguing, but its mechanism has not been...

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Veröffentlicht in:	Pharmacological reports 2013, Vol.65 (5), p.1176-1184
Hauptverfasser:	Hołuj, Małgorzata, Bisaga, Adam, Popik, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Behavior, Addictive - psychology Behavior, Animal - drug effects Central Nervous System Stimulants - pharmacology cocaine Cocaine - pharmacology conditioned reward Conditioning, Psychological - drug effects Dose-Response Relationship, Drug Drug Interactions Drug Safety and Pharmacovigilance Male methadone Methadone - pharmacology Mice Mice, Inbred C57BL morphine Morphine - pharmacology Motivation - drug effects opioids Pharmacotherapy Pharmacy Reward sensitization Time Factors
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