Glycerol and Acetaminophen as Adjuvant Therapy Did Not Affect the Outcome of Bacterial Meningitis in Malawian Children
We investigated the benefit of 2 candidate adjunctive therapies in bacterial meningitisglycerol, which has shown promise in earlier studies, and acetaminophen, which is reportedly beneficial in adult septicemia. In a hospital in Blantyre, Malawi, we enrolled 360 children aged ≥ 2 months with proven...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2014-02, Vol.33 (2), p.214-216 |
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| container_title | The Pediatric infectious disease journal |
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| creator | Molyneux, Elizabeth M Kawaza, Kondwani Phiri, Ajib Chimalizeni, Yamikani Mankhambo, Limangeni Schwalbe, Edward Kataja, Matti Pensulo, Paul Chilton, Lucy Peltola, Heikki |
| description | We investigated the benefit of 2 candidate adjunctive therapies in bacterial meningitisglycerol, which has shown promise in earlier studies, and acetaminophen, which is reportedly beneficial in adult septicemia. In a hospital in Blantyre, Malawi, we enrolled 360 children aged ≥ 2 months with proven bacterial meningitis (36% HIV infected) in a double-blind, randomized, placebo-controlled trial of glycerol and acetaminophen in a 2 × 2 factorial design. Of 4 groups, first group received oral glycerol, second received rectal acetaminophen, third received both therapies and the fourth received placebos only. Adjuvant therapies were given for the first 48 hours of antibiotic therapy. Endpoints were mortality and neurological sequelae. Baseline findings were similar across all groups, except that many children had prior antibiotics in the acetaminophen group and many were anemic in the acetaminophen and glycerol group. Outcomes were similar for all groups. We found no benefit from oral glycerol or rectal acetaminophen in, mostly pneumococcal, meningitis in Malawian children. |
| doi_str_mv | 10.1097/INF.0000000000000122 |
| format | Article |
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In a hospital in Blantyre, Malawi, we enrolled 360 children aged ≥ 2 months with proven bacterial meningitis (36% HIV infected) in a double-blind, randomized, placebo-controlled trial of glycerol and acetaminophen in a 2 × 2 factorial design. Of 4 groups, first group received oral glycerol, second received rectal acetaminophen, third received both therapies and the fourth received placebos only. Adjuvant therapies were given for the first 48 hours of antibiotic therapy. Endpoints were mortality and neurological sequelae. Baseline findings were similar across all groups, except that many children had prior antibiotics in the acetaminophen group and many were anemic in the acetaminophen and glycerol group. Outcomes were similar for all groups. We found no benefit from oral glycerol or rectal acetaminophen in, mostly pneumococcal, meningitis in Malawian children.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/INF.0000000000000122</identifier><identifier>PMID: 24136368</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Hagerstown, MD: by Lippincott Williams & Wilkins, Inc</publisher><subject>Acetaminophen - therapeutic use ; Anti-Bacterial Agents - therapeutic use ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Biological and medical sciences ; Ceftriaxone - therapeutic use ; Double-Blind Method ; Drug Therapy, Combination ; Glycerol - therapeutic use ; Hearing Loss - microbiology ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Malawi ; Medical sciences ; Meningitis, Bacterial - drug therapy ; Treatment Outcome</subject><ispartof>The Pediatric infectious disease journal, 2014-02, Vol.33 (2), p.214-216</ispartof><rights>2014 by Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4322-4d073d22261416c13595533e01aa567ab71a02a6b560aa8eaf8224d08a4527e13</citedby><cites>FETCH-LOGICAL-c4322-4d073d22261416c13595533e01aa567ab71a02a6b560aa8eaf8224d08a4527e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28203429$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24136368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molyneux, Elizabeth M</creatorcontrib><creatorcontrib>Kawaza, Kondwani</creatorcontrib><creatorcontrib>Phiri, Ajib</creatorcontrib><creatorcontrib>Chimalizeni, Yamikani</creatorcontrib><creatorcontrib>Mankhambo, Limangeni</creatorcontrib><creatorcontrib>Schwalbe, Edward</creatorcontrib><creatorcontrib>Kataja, Matti</creatorcontrib><creatorcontrib>Pensulo, Paul</creatorcontrib><creatorcontrib>Chilton, Lucy</creatorcontrib><creatorcontrib>Peltola, Heikki</creatorcontrib><title>Glycerol and Acetaminophen as Adjuvant Therapy Did Not Affect the Outcome of Bacterial Meningitis in Malawian Children</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>We investigated the benefit of 2 candidate adjunctive therapies in bacterial meningitisglycerol, which has shown promise in earlier studies, and acetaminophen, which is reportedly beneficial in adult septicemia. In a hospital in Blantyre, Malawi, we enrolled 360 children aged ≥ 2 months with proven bacterial meningitis (36% HIV infected) in a double-blind, randomized, placebo-controlled trial of glycerol and acetaminophen in a 2 × 2 factorial design. Of 4 groups, first group received oral glycerol, second received rectal acetaminophen, third received both therapies and the fourth received placebos only. Adjuvant therapies were given for the first 48 hours of antibiotic therapy. Endpoints were mortality and neurological sequelae. Baseline findings were similar across all groups, except that many children had prior antibiotics in the acetaminophen group and many were anemic in the acetaminophen and glycerol group. Outcomes were similar for all groups. We found no benefit from oral glycerol or rectal acetaminophen in, mostly pneumococcal, meningitis in Malawian children.</description><subject>Acetaminophen - therapeutic use</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Biological and medical sciences</subject><subject>Ceftriaxone - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Glycerol - therapeutic use</subject><subject>Hearing Loss - microbiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Malawi</subject><subject>Medical sciences</subject><subject>Meningitis, Bacterial - drug therapy</subject><subject>Treatment Outcome</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EotuWf4CQL0hcUvyROM5xWWip1I9Le45mnQlxcezFdrraf0-qXWjFgbnM5XlnRs8Q8p6zM86a-vPlzfkZe1lciFdkwSspCtbo-jVZMN3wQiqlj8hxSg8zI0vO3pIjUXKppNIL8njhdgZjcBR8R5cGM4zWh82AnkKiy-5hegSf6d2AETY7-tV29CZkuux7NJnmAentlE0YkYaefgGTMVpw9Bq99T9stolaT6_BwdaCp6vBui6iPyVvenAJ3x36Cbk__3a3-l5c3V5crpZXhSmlEEXZsVp2QgjFS64Ml1VTVVIi4wCVqmFdc2AC1LpSDEAj9FqIOaShrESNXJ6QT_u5mxh-TZhyO9pk0DnwGKbU8rJhNasYq2a03KMmhpQi9u0m2hHiruWsfTLezsbbf43PsQ-HDdN6xO5v6I_iGfh4ACAZcH0Eb2x65rSYvyKamdN7bhvcLDH9dNMWYzsguDz8_4bfGdyYTQ</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Molyneux, Elizabeth M</creator><creator>Kawaza, Kondwani</creator><creator>Phiri, Ajib</creator><creator>Chimalizeni, Yamikani</creator><creator>Mankhambo, Limangeni</creator><creator>Schwalbe, Edward</creator><creator>Kataja, Matti</creator><creator>Pensulo, Paul</creator><creator>Chilton, Lucy</creator><creator>Peltola, Heikki</creator><general>by Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Glycerol and Acetaminophen as Adjuvant Therapy Did Not Affect the Outcome of Bacterial Meningitis in Malawian Children</title><author>Molyneux, Elizabeth M ; Kawaza, Kondwani ; Phiri, Ajib ; Chimalizeni, Yamikani ; Mankhambo, Limangeni ; Schwalbe, Edward ; Kataja, Matti ; Pensulo, Paul ; Chilton, Lucy ; Peltola, Heikki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4322-4d073d22261416c13595533e01aa567ab71a02a6b560aa8eaf8224d08a4527e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetaminophen - therapeutic use</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Biological and medical sciences</topic><topic>Ceftriaxone - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Glycerol - therapeutic use</topic><topic>Hearing Loss - microbiology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Malawi</topic><topic>Medical sciences</topic><topic>Meningitis, Bacterial - drug therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molyneux, Elizabeth M</creatorcontrib><creatorcontrib>Kawaza, Kondwani</creatorcontrib><creatorcontrib>Phiri, Ajib</creatorcontrib><creatorcontrib>Chimalizeni, Yamikani</creatorcontrib><creatorcontrib>Mankhambo, Limangeni</creatorcontrib><creatorcontrib>Schwalbe, Edward</creatorcontrib><creatorcontrib>Kataja, Matti</creatorcontrib><creatorcontrib>Pensulo, Paul</creatorcontrib><creatorcontrib>Chilton, Lucy</creatorcontrib><creatorcontrib>Peltola, Heikki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molyneux, Elizabeth M</au><au>Kawaza, Kondwani</au><au>Phiri, Ajib</au><au>Chimalizeni, Yamikani</au><au>Mankhambo, Limangeni</au><au>Schwalbe, Edward</au><au>Kataja, Matti</au><au>Pensulo, Paul</au><au>Chilton, Lucy</au><au>Peltola, Heikki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycerol and Acetaminophen as Adjuvant Therapy Did Not Affect the Outcome of Bacterial Meningitis in Malawian Children</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2014-02</date><risdate>2014</risdate><volume>33</volume><issue>2</issue><spage>214</spage><epage>216</epage><pages>214-216</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>We investigated the benefit of 2 candidate adjunctive therapies in bacterial meningitisglycerol, which has shown promise in earlier studies, and acetaminophen, which is reportedly beneficial in adult septicemia. In a hospital in Blantyre, Malawi, we enrolled 360 children aged ≥ 2 months with proven bacterial meningitis (36% HIV infected) in a double-blind, randomized, placebo-controlled trial of glycerol and acetaminophen in a 2 × 2 factorial design. Of 4 groups, first group received oral glycerol, second received rectal acetaminophen, third received both therapies and the fourth received placebos only. Adjuvant therapies were given for the first 48 hours of antibiotic therapy. Endpoints were mortality and neurological sequelae. Baseline findings were similar across all groups, except that many children had prior antibiotics in the acetaminophen group and many were anemic in the acetaminophen and glycerol group. Outcomes were similar for all groups. 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| subjects | Acetaminophen - therapeutic use Anti-Bacterial Agents - therapeutic use Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Ceftriaxone - therapeutic use Double-Blind Method Drug Therapy, Combination Glycerol - therapeutic use Hearing Loss - microbiology Human bacterial diseases Humans Infant Infectious diseases Malawi Medical sciences Meningitis, Bacterial - drug therapy Treatment Outcome |
| title | Glycerol and Acetaminophen as Adjuvant Therapy Did Not Affect the Outcome of Bacterial Meningitis in Malawian Children |
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