A Competitive Chemical-Proteomic Platform To Identify Zinc-Binding Cysteines

Zinc ions (Zn2+) play vital catalytic, structural, and regulatory roles in protein function and are commonly chelated to cysteine residues within the protein framework. Current methods to identify Zn2+-binding cysteines rely on computational studies based on known Zn2+-chelating motifs, as well as h...

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Veröffentlicht in:	ACS chemical biology 2014-01, Vol.9 (1), p.258-265
Hauptverfasser:	Pace, Nicholas J, Weerapana, Eranthie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Cysteine - chemistry Cysteine - metabolism Glutathione Transferase - chemistry Glutathione Transferase - metabolism HeLa Cells Humans L-Iditol 2-Dehydrogenase - chemistry L-Iditol 2-Dehydrogenase - metabolism Molecular Sequence Data Proteomics - methods Zinc - metabolism
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