Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Colony stimulating factor 1 (CSF-1) recruits tumor-infiltrating myeloid cells (TIM) that suppress tumor immunity, including M2 macrophages and myeloid-derived suppressor cells (MDSC). The CSF-1 receptor (CSF-1R) is a tyrosine kinase that is targetable by small molecule inhibitors such as PLX3397. In...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014, Vol.74 (1), p.153-161
Hauptverfasser:	MOK, Stephen, KOYA, Richard C, TSUI, Christopher, JINGYING XU, ROBERT, Lidia, WU, Lily, GRAEBER, Thomas G, WEST, Brian L, BOLLAG, Gideon, RIBAS, Antoni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cell Survival - immunology Immunotherapy, Adoptive - methods Medical sciences Melanoma - enzymology Melanoma - immunology Melanoma - pathology Melanoma - therapy Mice Mice, Inbred C57BL Mice, Transgenic Pharmacology. Drug treatments Protein Kinase Inhibitors - pharmacology Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors Receptor, Macrophage Colony-Stimulating Factor - immunology Tumors
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