Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study
Summary Objectives The purposes of this study were to investigate the prevalence and distribution of intervertebral disc degeneration (DD) over the entire spine using magnetic resonance imaging (MRI), and to examine the factors and symptoms potentially associated with DD. Design This study included...
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Veröffentlicht in: | Osteoarthritis and cartilage 2014-01, Vol.22 (1), p.104-110 |
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creator | Teraguchi, M Yoshimura, N Hashizume, H Muraki, S Yamada, H Minamide, A Oka, H Ishimoto, Y Nagata, K Kagotani, R Takiguchi, N Akune, T Kawaguchi, H Nakamura, K Yoshida, M |
description | Summary Objectives The purposes of this study were to investigate the prevalence and distribution of intervertebral disc degeneration (DD) over the entire spine using magnetic resonance imaging (MRI), and to examine the factors and symptoms potentially associated with DD. Design This study included 975 participants (324 men, mean age of 67.2 years; 651 women, mean age of 66.0 years) with an age range of 21–97 years in the Wakayama Spine Study. DD on MRI was classified into Pfirrmann's system (grades 4 and 5 indicating DD). We assessed the prevalence of DD at each level in the cervical, thoracic, and lumbar regions and the entire spine, and examined DD-associated factors and symptoms. Results The prevalence of DD over the entire spine was 71% in men and 77% in women aged 90% in both men and women aged >50 years. The prevalence of an intervertebral space with DD was highest at C5/6 (men: 51.5%, women: 46%), T6/7 (men: 32.4%, women: 37.7%), and L4/5 (men: 69.1%, women: 75.8%). Age and obesity were associated with the presence of DD in all regions. Low back pain was associated with the presence of DD in the lumbar region. Conclusion The current study established the baseline data of DD over the entire spine in a large population of elderly individuals. These data provide the foundation for elucidating the causes and mechanisms of DD. |
doi_str_mv | 10.1016/j.joca.2013.10.019 |
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Design This study included 975 participants (324 men, mean age of 67.2 years; 651 women, mean age of 66.0 years) with an age range of 21–97 years in the Wakayama Spine Study. DD on MRI was classified into Pfirrmann's system (grades 4 and 5 indicating DD). We assessed the prevalence of DD at each level in the cervical, thoracic, and lumbar regions and the entire spine, and examined DD-associated factors and symptoms. Results The prevalence of DD over the entire spine was 71% in men and 77% in women aged <50 years, and >90% in both men and women aged >50 years. The prevalence of an intervertebral space with DD was highest at C5/6 (men: 51.5%, women: 46%), T6/7 (men: 32.4%, women: 37.7%), and L4/5 (men: 69.1%, women: 75.8%). Age and obesity were associated with the presence of DD in all regions. Low back pain was associated with the presence of DD in the lumbar region. Conclusion The current study established the baseline data of DD over the entire spine in a large population of elderly individuals. These data provide the foundation for elucidating the causes and mechanisms of DD.</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1016/j.joca.2013.10.019</identifier><identifier>PMID: 24239943</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Body Mass Index ; Cervical Vertebrae - pathology ; Cohort Studies ; Distribution ; Entire spine ; Female ; Humans ; Intervertebral disc degeneration ; Intervertebral Disc Degeneration - epidemiology ; Intervertebral Disc Degeneration - etiology ; Intervertebral Disc Degeneration - pathology ; Japan - epidemiology ; Low Back Pain - epidemiology ; Low Back Pain - etiology ; Lumbar Vertebrae - pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Obesity - complications ; Obesity - epidemiology ; Population-based cohort ; Prevalence ; Rheumatology ; Severity of Illness Index ; Sex Distribution ; Thoracic Vertebrae - pathology ; Young Adult</subject><ispartof>Osteoarthritis and cartilage, 2014-01, Vol.22 (1), p.104-110</ispartof><rights>Osteoarthritis Research Society International</rights><rights>2013 Osteoarthritis Research Society International</rights><rights>Copyright © 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-8ec3da5a17c2e35c79b8f5d05d844e9d881690cfc6f5bcac739324789952b6df3</citedby><cites>FETCH-LOGICAL-c529t-8ec3da5a17c2e35c79b8f5d05d844e9d881690cfc6f5bcac739324789952b6df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1063458413010029$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24239943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teraguchi, M</creatorcontrib><creatorcontrib>Yoshimura, N</creatorcontrib><creatorcontrib>Hashizume, H</creatorcontrib><creatorcontrib>Muraki, S</creatorcontrib><creatorcontrib>Yamada, H</creatorcontrib><creatorcontrib>Minamide, A</creatorcontrib><creatorcontrib>Oka, H</creatorcontrib><creatorcontrib>Ishimoto, Y</creatorcontrib><creatorcontrib>Nagata, K</creatorcontrib><creatorcontrib>Kagotani, R</creatorcontrib><creatorcontrib>Takiguchi, N</creatorcontrib><creatorcontrib>Akune, T</creatorcontrib><creatorcontrib>Kawaguchi, H</creatorcontrib><creatorcontrib>Nakamura, K</creatorcontrib><creatorcontrib>Yoshida, M</creatorcontrib><title>Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>Summary Objectives The purposes of this study were to investigate the prevalence and distribution of intervertebral disc degeneration (DD) over the entire spine using magnetic resonance imaging (MRI), and to examine the factors and symptoms potentially associated with DD. Design This study included 975 participants (324 men, mean age of 67.2 years; 651 women, mean age of 66.0 years) with an age range of 21–97 years in the Wakayama Spine Study. DD on MRI was classified into Pfirrmann's system (grades 4 and 5 indicating DD). We assessed the prevalence of DD at each level in the cervical, thoracic, and lumbar regions and the entire spine, and examined DD-associated factors and symptoms. Results The prevalence of DD over the entire spine was 71% in men and 77% in women aged <50 years, and >90% in both men and women aged >50 years. The prevalence of an intervertebral space with DD was highest at C5/6 (men: 51.5%, women: 46%), T6/7 (men: 32.4%, women: 37.7%), and L4/5 (men: 69.1%, women: 75.8%). Age and obesity were associated with the presence of DD in all regions. Low back pain was associated with the presence of DD in the lumbar region. Conclusion The current study established the baseline data of DD over the entire spine in a large population of elderly individuals. These data provide the foundation for elucidating the causes and mechanisms of DD.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body Mass Index</subject><subject>Cervical Vertebrae - pathology</subject><subject>Cohort Studies</subject><subject>Distribution</subject><subject>Entire spine</subject><subject>Female</subject><subject>Humans</subject><subject>Intervertebral disc degeneration</subject><subject>Intervertebral Disc Degeneration - epidemiology</subject><subject>Intervertebral Disc Degeneration - etiology</subject><subject>Intervertebral Disc Degeneration - pathology</subject><subject>Japan - epidemiology</subject><subject>Low Back Pain - epidemiology</subject><subject>Low Back Pain - etiology</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Population-based cohort</subject><subject>Prevalence</subject><subject>Rheumatology</subject><subject>Severity of Illness Index</subject><subject>Sex Distribution</subject><subject>Thoracic Vertebrae - pathology</subject><subject>Young Adult</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks2KFDEUhYMoztj6Ai4kSzfV5qdSVRERhsE_GFBoxWVIJbec1FQnZZJq6HfwoU11jy5cuEq49zsX7jkXoeeUbCmhzatxOwajt4xQXgpbQuUDdEkFY5VsBH9Y_qThVS26-gI9SWkkhHBKyWN0wWrGpaz5Jfr1JcJBT-ANYO0tti7l6Polu-BxGLDzGeIBYoY-6mltG2zhB3iI-syUJs63gMFnFwGn2XkoMqzxHOZlOlFVrxNYbMJtiPn1Cf-u7_RR7zXenQS7vNjjU_Ro0FOCZ_fvBn17_-7r9cfq5vOHT9dXN5URTOaqA8OtFpq2hgEXppV9NwhLhO3qGqTtOtpIYgbTDKI32rRccla3nZSC9Y0d-Aa9PM-dY_i5QMpqX_aCadIewpIUrSVpCRPFpQ1iZ9TEkFKEQc3R7XU8KkrUmoIa1ZqCWlNYayWFInpxP3_p92D_Sv7YXoA3ZwDKlgcHUSXj1gxssdBkZYP7__y3_8jN5LwzerqDI6QxLNEX_xRViSmidusdrGdAOaGEMMl_A9d3sDs</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Teraguchi, M</creator><creator>Yoshimura, N</creator><creator>Hashizume, H</creator><creator>Muraki, S</creator><creator>Yamada, H</creator><creator>Minamide, A</creator><creator>Oka, H</creator><creator>Ishimoto, Y</creator><creator>Nagata, K</creator><creator>Kagotani, R</creator><creator>Takiguchi, N</creator><creator>Akune, T</creator><creator>Kawaguchi, H</creator><creator>Nakamura, K</creator><creator>Yoshida, M</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study</title><author>Teraguchi, M ; Yoshimura, N ; Hashizume, H ; Muraki, S ; Yamada, H ; Minamide, A ; Oka, H ; Ishimoto, Y ; Nagata, K ; Kagotani, R ; Takiguchi, N ; Akune, T ; Kawaguchi, H ; Nakamura, K ; Yoshida, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-8ec3da5a17c2e35c79b8f5d05d844e9d881690cfc6f5bcac739324789952b6df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body Mass Index</topic><topic>Cervical Vertebrae - pathology</topic><topic>Cohort Studies</topic><topic>Distribution</topic><topic>Entire spine</topic><topic>Female</topic><topic>Humans</topic><topic>Intervertebral disc degeneration</topic><topic>Intervertebral Disc Degeneration - epidemiology</topic><topic>Intervertebral Disc Degeneration - etiology</topic><topic>Intervertebral Disc Degeneration - pathology</topic><topic>Japan - epidemiology</topic><topic>Low Back Pain - epidemiology</topic><topic>Low Back Pain - etiology</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Population-based cohort</topic><topic>Prevalence</topic><topic>Rheumatology</topic><topic>Severity of Illness Index</topic><topic>Sex Distribution</topic><topic>Thoracic Vertebrae - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teraguchi, M</creatorcontrib><creatorcontrib>Yoshimura, N</creatorcontrib><creatorcontrib>Hashizume, H</creatorcontrib><creatorcontrib>Muraki, S</creatorcontrib><creatorcontrib>Yamada, H</creatorcontrib><creatorcontrib>Minamide, A</creatorcontrib><creatorcontrib>Oka, H</creatorcontrib><creatorcontrib>Ishimoto, Y</creatorcontrib><creatorcontrib>Nagata, K</creatorcontrib><creatorcontrib>Kagotani, R</creatorcontrib><creatorcontrib>Takiguchi, N</creatorcontrib><creatorcontrib>Akune, T</creatorcontrib><creatorcontrib>Kawaguchi, H</creatorcontrib><creatorcontrib>Nakamura, K</creatorcontrib><creatorcontrib>Yoshida, M</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teraguchi, M</au><au>Yoshimura, N</au><au>Hashizume, H</au><au>Muraki, S</au><au>Yamada, H</au><au>Minamide, A</au><au>Oka, H</au><au>Ishimoto, Y</au><au>Nagata, K</au><au>Kagotani, R</au><au>Takiguchi, N</au><au>Akune, T</au><au>Kawaguchi, H</au><au>Nakamura, K</au><au>Yoshida, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>22</volume><issue>1</issue><spage>104</spage><epage>110</epage><pages>104-110</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>Summary Objectives The purposes of this study were to investigate the prevalence and distribution of intervertebral disc degeneration (DD) over the entire spine using magnetic resonance imaging (MRI), and to examine the factors and symptoms potentially associated with DD. Design This study included 975 participants (324 men, mean age of 67.2 years; 651 women, mean age of 66.0 years) with an age range of 21–97 years in the Wakayama Spine Study. DD on MRI was classified into Pfirrmann's system (grades 4 and 5 indicating DD). We assessed the prevalence of DD at each level in the cervical, thoracic, and lumbar regions and the entire spine, and examined DD-associated factors and symptoms. Results The prevalence of DD over the entire spine was 71% in men and 77% in women aged <50 years, and >90% in both men and women aged >50 years. The prevalence of an intervertebral space with DD was highest at C5/6 (men: 51.5%, women: 46%), T6/7 (men: 32.4%, women: 37.7%), and L4/5 (men: 69.1%, women: 75.8%). Age and obesity were associated with the presence of DD in all regions. Low back pain was associated with the presence of DD in the lumbar region. Conclusion The current study established the baseline data of DD over the entire spine in a large population of elderly individuals. These data provide the foundation for elucidating the causes and mechanisms of DD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24239943</pmid><doi>10.1016/j.joca.2013.10.019</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Age Distribution Aged Aged, 80 and over Body Mass Index Cervical Vertebrae - pathology Cohort Studies Distribution Entire spine Female Humans Intervertebral disc degeneration Intervertebral Disc Degeneration - epidemiology Intervertebral Disc Degeneration - etiology Intervertebral Disc Degeneration - pathology Japan - epidemiology Low Back Pain - epidemiology Low Back Pain - etiology Lumbar Vertebrae - pathology Magnetic Resonance Imaging Male Middle Aged Obesity - complications Obesity - epidemiology Population-based cohort Prevalence Rheumatology Severity of Illness Index Sex Distribution Thoracic Vertebrae - pathology Young Adult |
title | Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study |
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