Role of L1 cell adhesion molecule (L1CAM) in the metastatic cascade: promotion of dissemination, colonization, and metastatic growth

Expression of the L1 cell adhesion molecule (L1CAM) is frequently increased in cancer patients compared to healthy individuals and also linked with bad prognosis of solid tumours. Previously, we could show that full-length L1CAM promotes metastasis formation via up-regulation of gelatinolytic activi...

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Veröffentlicht in:	Clinical & experimental metastasis 2014, Vol.31 (1), p.87-100
Hauptverfasser:	Weinspach, Dirk, Seubert, Bastian, Schaten, Susanne, Honert, Katja, Sebens, Susanne, Altevogt, Peter, Krüger, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Flow Cytometry Hematology Humans Immunohistochemistry Immunoprecipitation Mice Neoplasm Invasiveness - physiopathology Neoplasm Metastasis Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neural Cell Adhesion Molecule L1 - metabolism Oncology Research Paper Reverse Transcriptase Polymerase Chain Reaction Surgical Oncology
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