The mechanism of the opening of the blood–brain barrier by borneol: A pharmacodynamics and pharmacokinetics combination study

Borneol is widely used in traditional Chinese medicine to facilitate the distribution of central nervous system (CNS) drugs in brain due to its ability to open blood–brain barrier (BBB), however, the underlying mechanism is still unclear. In this study, the effect of borneol on different brain regio...

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Veröffentlicht in:	Journal of ethnopharmacology 2013-12, Vol.150 (3), p.1096-1108
Hauptverfasser:	Yu, Bin, Ruan, Ming, Dong, Xiaoping, Yu, Yun, Cheng, Haibo
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Animals ATP-binding cassette proteins ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - ultrastructure Blood–brain barrier Bornanes - blood Bornanes - pharmacokinetics Bornanes - pharmacology Borneol Brain - drug effects Brain - metabolism breast neoplasms cortex drugs fluorescence hippocampus hypothalamus Male Multidrug Resistance-Associated Proteins - metabolism multiple drug resistance oral administration Oriental traditional medicine permeability pharmacokinetics protein synthesis Rats Rats, Sprague-Dawley Rhodamine 123 - pharmacokinetics synergism tight junctions Tissue specific Ultrastructure Verapamil - pharmacology
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