Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction

The effect of denzimol (DNZ) on the disposition of carbamazepine (CBZ) and its primary metabolite carbamazepine-10,11-epoxide (CBZ-E) in serum, liver, spleen and seven brain regions of the rat was assessed. Coadministration with DNZ for 5 or 10 days resulted in an increase in CBZ and a decrease in C...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1988, Vol.337 (1), p.111-114
Hauptverfasser:	PATSALOS, P. N, ALAVIJEH, M. S, BROWNHILL, W, LASCELLES, P. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain - metabolism Carbamazepine - analogs & derivatives Carbamazepine - blood Carbamazepine - pharmacokinetics Drug Interactions Imidazoles - pharmacology Liver - metabolism Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Spleen - metabolism
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