Developmental Lead Exposure Impairs Anxiolytic-Like Effects of Diazepam and 8-OH-DPAT in Male Wistar Rats
Behavioral modification of developmental Pb super(2+) exposure responses to diazepam and 8-OH-DPAT in male offspring rats was examined. Group differences were assessed by a two-way analysis of variance (ANOVA) and the post-ANOVA test of Newman-Keuls. Diazepam in a dose of 5.0 mg/kg IP significantly...
Gespeichert in:
Veröffentlicht in: | Polish journal of environmental studies 2008-01, Vol.17 (5), p.751-751 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 751 |
---|---|
container_issue | 5 |
container_start_page | 751 |
container_title | Polish journal of environmental studies |
container_volume | 17 |
creator | Nowak, P Kostrzewa, R M Adamus-Sitkiewicz, B Brus, R |
description | Behavioral modification of developmental Pb super(2+) exposure responses to diazepam and 8-OH-DPAT in male offspring rats was examined. Group differences were assessed by a two-way analysis of variance (ANOVA) and the post-ANOVA test of Newman-Keuls. Diazepam in a dose of 5.0 mg/kg IP significantly increased the percentage of time spent on open arms in control rats being without effect in this regard in Pb super(2+)-exposed animals. It was also observed that the lack of Pb super(2+)-exposure effect on basal anxiety evaluated in the elevated plus maze and Vogel drinking test. It was also shown that 8-OH- DPAT 0.3 mg/kg IP increased the percentage of time spent. |
format | Article |
fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_14872017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14872017</sourcerecordid><originalsourceid>FETCH-LOGICAL-p186t-2a15b1da6646760eab9178130acf39a08c637722e8b7be644cbaea122d6f2afc3</originalsourceid><addsrcrecordid>eNot0L1OwzAUQOEMIFEK73AnNku2k9ruGDWFVgoqQkWM1Y1zLRmcH2IHFZ4eJJjO9g3nIlsImXMmCrO6yq5jfONcGK7UIvMVfVIYxo76hAFqwha253GI80Sw70b0U4SyP_shfCVvWe3fCbbOkU0RBgeVx28asQPsWzDssGPVU3kE38MjBoJXHxNO8Iwp3mSXDkOk2_8us5f77XGzY_XhYb8pazYKoxKTKFaNaFGpQmnFCZu10EbkHK3L18iNVbnWUpJpdEOqKGyDhELKVjmJzubL7O7PHafhY6aYTp2PlkLAnoY5nn4naMmFzn8AQyBTfg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14872017</pqid></control><display><type>article</type><title>Developmental Lead Exposure Impairs Anxiolytic-Like Effects of Diazepam and 8-OH-DPAT in Male Wistar Rats</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Nowak, P ; Kostrzewa, R M ; Adamus-Sitkiewicz, B ; Brus, R</creator><creatorcontrib>Nowak, P ; Kostrzewa, R M ; Adamus-Sitkiewicz, B ; Brus, R</creatorcontrib><description>Behavioral modification of developmental Pb super(2+) exposure responses to diazepam and 8-OH-DPAT in male offspring rats was examined. Group differences were assessed by a two-way analysis of variance (ANOVA) and the post-ANOVA test of Newman-Keuls. Diazepam in a dose of 5.0 mg/kg IP significantly increased the percentage of time spent on open arms in control rats being without effect in this regard in Pb super(2+)-exposed animals. It was also observed that the lack of Pb super(2+)-exposure effect on basal anxiety evaluated in the elevated plus maze and Vogel drinking test. It was also shown that 8-OH- DPAT 0.3 mg/kg IP increased the percentage of time spent.</description><identifier>ISSN: 1230-1485</identifier><language>eng</language><ispartof>Polish journal of environmental studies, 2008-01, Vol.17 (5), p.751-751</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Nowak, P</creatorcontrib><creatorcontrib>Kostrzewa, R M</creatorcontrib><creatorcontrib>Adamus-Sitkiewicz, B</creatorcontrib><creatorcontrib>Brus, R</creatorcontrib><title>Developmental Lead Exposure Impairs Anxiolytic-Like Effects of Diazepam and 8-OH-DPAT in Male Wistar Rats</title><title>Polish journal of environmental studies</title><description>Behavioral modification of developmental Pb super(2+) exposure responses to diazepam and 8-OH-DPAT in male offspring rats was examined. Group differences were assessed by a two-way analysis of variance (ANOVA) and the post-ANOVA test of Newman-Keuls. Diazepam in a dose of 5.0 mg/kg IP significantly increased the percentage of time spent on open arms in control rats being without effect in this regard in Pb super(2+)-exposed animals. It was also observed that the lack of Pb super(2+)-exposure effect on basal anxiety evaluated in the elevated plus maze and Vogel drinking test. It was also shown that 8-OH- DPAT 0.3 mg/kg IP increased the percentage of time spent.</description><issn>1230-1485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNot0L1OwzAUQOEMIFEK73AnNku2k9ruGDWFVgoqQkWM1Y1zLRmcH2IHFZ4eJJjO9g3nIlsImXMmCrO6yq5jfONcGK7UIvMVfVIYxo76hAFqwha253GI80Sw70b0U4SyP_shfCVvWe3fCbbOkU0RBgeVx28asQPsWzDssGPVU3kE38MjBoJXHxNO8Iwp3mSXDkOk2_8us5f77XGzY_XhYb8pazYKoxKTKFaNaFGpQmnFCZu10EbkHK3L18iNVbnWUpJpdEOqKGyDhELKVjmJzubL7O7PHafhY6aYTp2PlkLAnoY5nn4naMmFzn8AQyBTfg</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Nowak, P</creator><creator>Kostrzewa, R M</creator><creator>Adamus-Sitkiewicz, B</creator><creator>Brus, R</creator><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20080101</creationdate><title>Developmental Lead Exposure Impairs Anxiolytic-Like Effects of Diazepam and 8-OH-DPAT in Male Wistar Rats</title><author>Nowak, P ; Kostrzewa, R M ; Adamus-Sitkiewicz, B ; Brus, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p186t-2a15b1da6646760eab9178130acf39a08c637722e8b7be644cbaea122d6f2afc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nowak, P</creatorcontrib><creatorcontrib>Kostrzewa, R M</creatorcontrib><creatorcontrib>Adamus-Sitkiewicz, B</creatorcontrib><creatorcontrib>Brus, R</creatorcontrib><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Polish journal of environmental studies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nowak, P</au><au>Kostrzewa, R M</au><au>Adamus-Sitkiewicz, B</au><au>Brus, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental Lead Exposure Impairs Anxiolytic-Like Effects of Diazepam and 8-OH-DPAT in Male Wistar Rats</atitle><jtitle>Polish journal of environmental studies</jtitle><date>2008-01-01</date><risdate>2008</risdate><volume>17</volume><issue>5</issue><spage>751</spage><epage>751</epage><pages>751-751</pages><issn>1230-1485</issn><abstract>Behavioral modification of developmental Pb super(2+) exposure responses to diazepam and 8-OH-DPAT in male offspring rats was examined. Group differences were assessed by a two-way analysis of variance (ANOVA) and the post-ANOVA test of Newman-Keuls. Diazepam in a dose of 5.0 mg/kg IP significantly increased the percentage of time spent on open arms in control rats being without effect in this regard in Pb super(2+)-exposed animals. It was also observed that the lack of Pb super(2+)-exposure effect on basal anxiety evaluated in the elevated plus maze and Vogel drinking test. It was also shown that 8-OH- DPAT 0.3 mg/kg IP increased the percentage of time spent.</abstract><tpages>1</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1230-1485 |
ispartof | Polish journal of environmental studies, 2008-01, Vol.17 (5), p.751-751 |
issn | 1230-1485 |
language | eng |
recordid | cdi_proquest_miscellaneous_14872017 |
source | EZB-FREE-00999 freely available EZB journals |
title | Developmental Lead Exposure Impairs Anxiolytic-Like Effects of Diazepam and 8-OH-DPAT in Male Wistar Rats |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A13%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Developmental%20Lead%20Exposure%20Impairs%20Anxiolytic-Like%20Effects%20of%20Diazepam%20and%208-OH-DPAT%20in%20Male%20Wistar%20Rats&rft.jtitle=Polish%20journal%20of%20environmental%20studies&rft.au=Nowak,%20P&rft.date=2008-01-01&rft.volume=17&rft.issue=5&rft.spage=751&rft.epage=751&rft.pages=751-751&rft.issn=1230-1485&rft_id=info:doi/&rft_dat=%3Cproquest%3E14872017%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14872017&rft_id=info:pmid/&rfr_iscdi=true |