The reaction of bovine alpha-thrombin with tetranitromethane. Characterization of the modified protein

Previous studies from several laboratories have shown that thrombin is inactivated by tetranitromethane with the formation of nitrotyrosine. The inactivation is characterized by an apparently greater loss of fibrinogen-clotting activity than activity toward synthetic ester substrates, suggesting tha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1988-03, Vol.263 (8), p.3729-3734
Hauptverfasser:	Lundblad, R L, Noyes, C M, Featherstone, G L, Harrison, J H, Jenzano, J W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cattle Enzymes and enzyme inhibitors fibrinogen Fundamental and applied biological sciences. Psychology Hydrolases Kinetics Methane - analogs & derivatives nitroanilide Peptide Fragments - analysis Peptide Mapping Protein Binding Solvents Substrate Specificity tetranitromethane Tetranitromethane - pharmacology thrombin Thrombin - antagonists & inhibitors Trypsin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!