Combined repeated dose and reproductive/developmental toxicity screening test of the nitrophenolic herbicide dinoseb, 2-sec-butyl-4,6-dinitrophenol, in rats

In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test, Crj:CD(SD)IGS rats were dosed with dinoseb, 2-sec-butyl-4,6-dinitrophenol, by gavage at 0 (vehicle), 0.78, 2.33, or 7.0 mg/kg bw/day. Six males per group were dosed for a total of 42 days beginning 14...

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Veröffentlicht in:	Environmental toxicology 2008-04, Vol.23 (2), p.169-183
Hauptverfasser:	Matsumoto, Mariko, Furuhashi, Tadakazu, Poncipe, Carlo, Ema, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-Dinitrophenol - analogs & derivatives 2,4-Dinitrophenol - toxicity 2-sec-butyl-4 2‐sec‐butyl‐4,6‐dinitrophenol 6-dinitrophenol Administration, Oral Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Body Weight - drug effects dinoseb Drug Synergism Ecotoxicology, biological effects of pollution Female Fundamental and applied biological sciences. Psychology General aspects Hematopoiesis, Extramedullary - drug effects Herbicides - toxicity Litter Size Male Maternal Exposure - adverse effects nitrophenolic herbicide No-Observed-Adverse-Effect Level Organ Size - drug effects Paternal Exposure - adverse effects Pregnancy rat Rats Rats, Inbred Strains repeated dose toxicity Reproduction - drug effects reproductive and developmental toxicity screening test Sperm Motility - drug effects Spermatozoa - drug effects Spermatozoa - pathology Spleen - drug effects testis toxicity Toxicity Tests
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