Role of serotonin in the regulation of human natural killer cell cytotoxicity

Addition of serotonin to mixtures of target cells and natural killer (NK)-enriched human mononuclear cells (MNC) in a 4-hr 51Cr-release assay strongly augmented NK cell cytotoxicity (NKCC) vs K562, Chang, or Molt-4 target cells. The effect was dose dependent at serotonin concentrations of 10(-4) to...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-08, Vol.139 (3), p.869-875
Hauptverfasser:	Hellstrand, K, Hermodsson, S
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin Applied sciences Cyproheptadine - pharmacology Cytotoxicity, Immunologic - drug effects Drug Synergism Exact sciences and technology Humans Interferons - pharmacology Ketanserin - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lymphocyte Culture Test, Mixed Lymphokines - secretion Monocytes - drug effects Monocytes - secretion Other techniques and industries Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Serotonin - pharmacology Serotonin - physiology Stimulation, Chemical Tetrahydronaphthalenes - pharmacology
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