Effects of inhalation of ethylene dichloride on pulmonary defenses of mice and rats
The effects of single or multiple inhalation exposures to ethylene dichloride (DCE) on the pulmonary defense systems of mice and rats were evaluated. Single exposures of mice to the threshold limit value of DCE (10 ppm) resulted in decreased pulmonary bactericidal activity to inhaled Klebsiella pneu...
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| Veröffentlicht in: | Toxicology and applied pharmacology 1987-12, Vol.91 (3), p.491-496 |
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| container_title | Toxicology and applied pharmacology |
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| creator | Sherwood, R.L. O'Shea, W. Thomas, P.T. Ratajczak, H.V. Aranyi, C. Graham, J.A. |
| description | The effects of single or multiple inhalation exposures to ethylene dichloride (DCE) on the pulmonary defense systems of mice and rats were evaluated. Single exposures of mice to the threshold limit value of DCE (10 ppm) resulted in decreased pulmonary bactericidal activity to inhaled
Klebsiella pneumoniae and increased mortality from
Streptococcus zooepidemicus respiratory infection. A single exposure to 5 ppm DCE caused increased mortality from streptococcal pneumonia although bactericidal activity was not affected. Neither of these two parameters changed following single or five consecutive daily exposures to 2.5 ppm DCE. Single exposures to 10 or 100 ppm DCE did not affect mouse alveolar macrophage (AM) inhibition of the proliferation of a tumor target cell
in vitro or AM
in vitro phagocytosis of red blood cells. In rats, no effects were observed on pulmonary bactericidal activity, AM
in vitro phagocytosis, AM cytostasis and cytolysis of tumor target cells, AM ectoenzymes, or blastogenesis of mitogen-stimulated rat T- and B-lymphocytes from lung-associated, mesenteric, and popliteal lymph nodes following single exposure to 100 or 200 ppm DCE or after twelve 5-hr exposures to 10, 20, 50, or 100 ppm DCE. |
| doi_str_mv | 10.1016/0041-008X(87)90071-8 |
| format | Article |
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Klebsiella pneumoniae and increased mortality from
Streptococcus zooepidemicus respiratory infection. A single exposure to 5 ppm DCE caused increased mortality from streptococcal pneumonia although bactericidal activity was not affected. Neither of these two parameters changed following single or five consecutive daily exposures to 2.5 ppm DCE. Single exposures to 10 or 100 ppm DCE did not affect mouse alveolar macrophage (AM) inhibition of the proliferation of a tumor target cell
in vitro or AM
in vitro phagocytosis of red blood cells. In rats, no effects were observed on pulmonary bactericidal activity, AM
in vitro phagocytosis, AM cytostasis and cytolysis of tumor target cells, AM ectoenzymes, or blastogenesis of mitogen-stimulated rat T- and B-lymphocytes from lung-associated, mesenteric, and popliteal lymph nodes following single exposure to 100 or 200 ppm DCE or after twelve 5-hr exposures to 10, 20, 50, or 100 ppm DCE.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/0041-008X(87)90071-8</identifier><identifier>PMID: 3424378</identifier><identifier>CODEN: TXAPA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Administration, Inhalation ; Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Disease Susceptibility ; Ethylene Dichlorides - toxicity ; Female ; Hydrocarbons, Chlorinated - toxicity ; Lung Diseases - chemically induced ; Lung Diseases - microbiology ; Lymphocyte Activation - drug effects ; Male ; Medical sciences ; Mice ; Mice, Inbred Strains ; Pulmonary Alveoli - drug effects ; Rats ; Rats, Inbred Strains ; Streptococcal Infections - etiology ; Toxicology ; Various organic compounds</subject><ispartof>Toxicology and applied pharmacology, 1987-12, Vol.91 (3), p.491-496</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f09f58ab0cc24c6aca00c050e6eb00a0d0adedb4b170268a0d9679eb5d0415c33</citedby><cites>FETCH-LOGICAL-c417t-f09f58ab0cc24c6aca00c050e6eb00a0d0adedb4b170268a0d9679eb5d0415c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-008X(87)90071-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7665593$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3424378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sherwood, R.L.</creatorcontrib><creatorcontrib>O'Shea, W.</creatorcontrib><creatorcontrib>Thomas, P.T.</creatorcontrib><creatorcontrib>Ratajczak, H.V.</creatorcontrib><creatorcontrib>Aranyi, C.</creatorcontrib><creatorcontrib>Graham, J.A.</creatorcontrib><title>Effects of inhalation of ethylene dichloride on pulmonary defenses of mice and rats</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>The effects of single or multiple inhalation exposures to ethylene dichloride (DCE) on the pulmonary defense systems of mice and rats were evaluated. Single exposures of mice to the threshold limit value of DCE (10 ppm) resulted in decreased pulmonary bactericidal activity to inhaled
Klebsiella pneumoniae and increased mortality from
Streptococcus zooepidemicus respiratory infection. A single exposure to 5 ppm DCE caused increased mortality from streptococcal pneumonia although bactericidal activity was not affected. Neither of these two parameters changed following single or five consecutive daily exposures to 2.5 ppm DCE. Single exposures to 10 or 100 ppm DCE did not affect mouse alveolar macrophage (AM) inhibition of the proliferation of a tumor target cell
in vitro or AM
in vitro phagocytosis of red blood cells. In rats, no effects were observed on pulmonary bactericidal activity, AM
in vitro phagocytosis, AM cytostasis and cytolysis of tumor target cells, AM ectoenzymes, or blastogenesis of mitogen-stimulated rat T- and B-lymphocytes from lung-associated, mesenteric, and popliteal lymph nodes following single exposure to 100 or 200 ppm DCE or after twelve 5-hr exposures to 10, 20, 50, or 100 ppm DCE.</description><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Disease Susceptibility</subject><subject>Ethylene Dichlorides - toxicity</subject><subject>Female</subject><subject>Hydrocarbons, Chlorinated - toxicity</subject><subject>Lung Diseases - chemically induced</subject><subject>Lung Diseases - microbiology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Pulmonary Alveoli - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Streptococcal Infections - etiology</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A4UeRPRQnWzTNL0IIn7BggcVvIU0mbCRNl2TrrD_3tRd9uhpmHnfd5h5CDmlcE2B8hsARnMA8XkpqqsaoKK52CETCjXPoSiKXTLZWg7IYYxfAFAzRvfJfsGmrKjEhLw9WIt6iFlvM-fnqlWD6_3Y4TBftegxM07P2z44g1lSFsu2670Kq8ygRR_xL9o5jZnyJgtqiMdkz6o24smmHpGPx4f3--d89vr0cn83yzWj1ZBbqG0pVANaT5nmSisADSUgxwZAgQFl0DSsoRVMuUiDmlc1NqVJX5W6KI7IxXrvIvTfS4yD7FzU2LbKY7-MkjJRcFHyZGRrow59jAGtXATXpR8kBTmylCMoOYKSopJ_LKVIsbPN_mXTodmGNvCSfr7RVdSqtUF57eLWVnFelvV45u3ahonFj8Mgo3boNRoXEnppevf_Hb_yPZCT</recordid><startdate>19871201</startdate><enddate>19871201</enddate><creator>Sherwood, R.L.</creator><creator>O'Shea, W.</creator><creator>Thomas, P.T.</creator><creator>Ratajczak, H.V.</creator><creator>Aranyi, C.</creator><creator>Graham, J.A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19871201</creationdate><title>Effects of inhalation of ethylene dichloride on pulmonary defenses of mice and rats</title><author>Sherwood, R.L. ; O'Shea, W. ; Thomas, P.T. ; Ratajczak, H.V. ; Aranyi, C. ; Graham, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f09f58ab0cc24c6aca00c050e6eb00a0d0adedb4b170268a0d9679eb5d0415c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Disease Susceptibility</topic><topic>Ethylene Dichlorides - toxicity</topic><topic>Female</topic><topic>Hydrocarbons, Chlorinated - toxicity</topic><topic>Lung Diseases - chemically induced</topic><topic>Lung Diseases - microbiology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Pulmonary Alveoli - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Streptococcal Infections - etiology</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sherwood, R.L.</creatorcontrib><creatorcontrib>O'Shea, W.</creatorcontrib><creatorcontrib>Thomas, P.T.</creatorcontrib><creatorcontrib>Ratajczak, H.V.</creatorcontrib><creatorcontrib>Aranyi, C.</creatorcontrib><creatorcontrib>Graham, J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sherwood, R.L.</au><au>O'Shea, W.</au><au>Thomas, P.T.</au><au>Ratajczak, H.V.</au><au>Aranyi, C.</au><au>Graham, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of inhalation of ethylene dichloride on pulmonary defenses of mice and rats</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1987-12-01</date><risdate>1987</risdate><volume>91</volume><issue>3</issue><spage>491</spage><epage>496</epage><pages>491-496</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>The effects of single or multiple inhalation exposures to ethylene dichloride (DCE) on the pulmonary defense systems of mice and rats were evaluated. Single exposures of mice to the threshold limit value of DCE (10 ppm) resulted in decreased pulmonary bactericidal activity to inhaled
Klebsiella pneumoniae and increased mortality from
Streptococcus zooepidemicus respiratory infection. A single exposure to 5 ppm DCE caused increased mortality from streptococcal pneumonia although bactericidal activity was not affected. Neither of these two parameters changed following single or five consecutive daily exposures to 2.5 ppm DCE. Single exposures to 10 or 100 ppm DCE did not affect mouse alveolar macrophage (AM) inhibition of the proliferation of a tumor target cell
in vitro or AM
in vitro phagocytosis of red blood cells. In rats, no effects were observed on pulmonary bactericidal activity, AM
in vitro phagocytosis, AM cytostasis and cytolysis of tumor target cells, AM ectoenzymes, or blastogenesis of mitogen-stimulated rat T- and B-lymphocytes from lung-associated, mesenteric, and popliteal lymph nodes following single exposure to 100 or 200 ppm DCE or after twelve 5-hr exposures to 10, 20, 50, or 100 ppm DCE.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3424378</pmid><doi>10.1016/0041-008X(87)90071-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | Toxicology and applied pharmacology, 1987-12, Vol.91 (3), p.491-496 |
| issn | 0041-008X 1096-0333 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Inhalation Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Disease Susceptibility Ethylene Dichlorides - toxicity Female Hydrocarbons, Chlorinated - toxicity Lung Diseases - chemically induced Lung Diseases - microbiology Lymphocyte Activation - drug effects Male Medical sciences Mice Mice, Inbred Strains Pulmonary Alveoli - drug effects Rats Rats, Inbred Strains Streptococcal Infections - etiology Toxicology Various organic compounds |
| title | Effects of inhalation of ethylene dichloride on pulmonary defenses of mice and rats |
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