Pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein
Several cDNA clones that contain the pen repeat have been isolated and sequenced; pen consists of clusters of GGN triplets, where N can be any nucleotide. Some of the pen repeat sequences are found within long open reading frames in which they encode oligoglycine stretches. For one of the clones, th...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1987-04, Vol.84 (7), p.1819-1823 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Haynes, S.R Rebbert, M.L Mozer, B.A Forquignon, F Dawid, I.B |
| description | Several cDNA clones that contain the pen repeat have been isolated and sequenced; pen consists of clusters of GGN triplets, where N can be any nucleotide. Some of the pen repeat sequences are found within long open reading frames in which they encode oligoglycine stretches. For one of the clones, the deduced amino acid sequence of the entire open reading frame, especially in the region preceding the glycinerich domain, shows strong homology to the rat helix destabilizing protein [Cobianchi, F., SenGupta, D. N., Zmudzka, B. Z. & Wilson, S. H. (1986) J. Biol. Chem. 261, 3536-3543]. The rat protein and homologs in other organisms are single-stranded nucleic acid binding proteins, some of which are major components of heterogeneous nuclear ribonucleoprotein particles. We suggest that we have cloned a cDNA encoding a Drosophila single-stranded nucleic acid binding protein. |
| doi_str_mv | 10.1073/pnas.84.7.1819 |
| format | Article |
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Some of the pen repeat sequences are found within long open reading frames in which they encode oligoglycine stretches. For one of the clones, the deduced amino acid sequence of the entire open reading frame, especially in the region preceding the glycinerich domain, shows strong homology to the rat helix destabilizing protein [Cobianchi, F., SenGupta, D. N., Zmudzka, B. Z. & Wilson, S. H. (1986) J. Biol. Chem. 261, 3536-3543]. The rat protein and homologs in other organisms are single-stranded nucleic acid binding proteins, some of which are major components of heterogeneous nuclear ribonucleoprotein particles. We suggest that we have cloned a cDNA encoding a Drosophila single-stranded nucleic acid binding protein.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.84.7.1819</identifier><identifier>PMID: 3031652</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>ADN ; Amino Acid Sequence ; Amino acids ; Animals ; Base Sequence ; Complementary DNA ; DNA ; DNA Helicases - genetics ; DNA probes ; DNA-Binding Proteins - genetics ; DROSOPHILA ; Drosophila - genetics ; Drosophila - growth & development ; Drosophilidae ; Genes ; GENETICA ; GENETICS ; GENETIQUE ; GENOMAS ; GENOME ; GENOMES ; Genomics ; Glycine ; NUCLEOTIDE ; nucleotide sequence ; NUCLEOTIDES ; NUCLEOTIDOS ; Open reading frames ; PROTEINAS ; PROTEINE ; PROTEINS ; repeated sequence ; Repetitive sequences ; Repetitive Sequences, Nucleic Acid ; Transcription, Genetic ; Viral Proteins</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1987-04, Vol.84 (7), p.1819-1823</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3909-1947d8c67d1351e89ac58412ea4c18004b15bb478731607d3f4a6968a80cf1bc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/84/7.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29538$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29538$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3031652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haynes, S.R</creatorcontrib><creatorcontrib>Rebbert, M.L</creatorcontrib><creatorcontrib>Mozer, B.A</creatorcontrib><creatorcontrib>Forquignon, F</creatorcontrib><creatorcontrib>Dawid, I.B</creatorcontrib><title>Pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Several cDNA clones that contain the pen repeat have been isolated and sequenced; pen consists of clusters of GGN triplets, where N can be any nucleotide. Some of the pen repeat sequences are found within long open reading frames in which they encode oligoglycine stretches. For one of the clones, the deduced amino acid sequence of the entire open reading frame, especially in the region preceding the glycinerich domain, shows strong homology to the rat helix destabilizing protein [Cobianchi, F., SenGupta, D. N., Zmudzka, B. Z. & Wilson, S. H. (1986) J. Biol. Chem. 261, 3536-3543]. The rat protein and homologs in other organisms are single-stranded nucleic acid binding proteins, some of which are major components of heterogeneous nuclear ribonucleoprotein particles. We suggest that we have cloned a cDNA encoding a Drosophila single-stranded nucleic acid binding protein.</description><subject>ADN</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Complementary DNA</subject><subject>DNA</subject><subject>DNA Helicases - genetics</subject><subject>DNA probes</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DROSOPHILA</subject><subject>Drosophila - genetics</subject><subject>Drosophila - growth & development</subject><subject>Drosophilidae</subject><subject>Genes</subject><subject>GENETICA</subject><subject>GENETICS</subject><subject>GENETIQUE</subject><subject>GENOMAS</subject><subject>GENOME</subject><subject>GENOMES</subject><subject>Genomics</subject><subject>Glycine</subject><subject>NUCLEOTIDE</subject><subject>nucleotide sequence</subject><subject>NUCLEOTIDES</subject><subject>NUCLEOTIDOS</subject><subject>Open reading frames</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>repeated sequence</subject><subject>Repetitive sequences</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Transcription, Genetic</subject><subject>Viral Proteins</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUGLFDEQhRtR1nH16kEQcvLWY9JJd5KDh2VXR2FZBd1zSKerp7NkkjbJyK7_wf9shhnHEYRAIN97Val6VfWS4CXBnL6dvU5LwZZ8SQSRj6oFwZLUHZP4cbXAuOG1YA17Wj1L6Q5jLFuBz6oziinp2mZR_foCHkWYQWeU4PsWvIGEdAS0Wt0g47YpQywPfkAFhQGQRmv3YKyHOlozoSFstPWoHI2uYkhhnqzTyFzdXKApbIIL67BNKAeUJ0CxtJnA2Xs0QMq6t87-tH6N5hgyWP-8ejJql-DF4T6vbj-8_3b5sb7-vPp0eXFdGyqxrIlkfBCm4wOhLQEhtWkFIw1oZojAmPWk7XvGBS9TYj7QkelOdkILbEbSG3pevdvXnbf9BgYDPkft1BztRscHFbRV_xJvJ7UOPxTFrKVN8b85-GMoO0tZbWwy4Jz2UKZVhAnaSNwV4XIvNGU1KcJ47EGw2uWndvkpwRRXu_yK4fXpz47yQ2AnnXe-P_ToV-PWuQz3-aTQf4WFv9rzu5RDPAoa2VLxF446KL2ONqnbr4I3vCvwN9zowX8</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>Haynes, S.R</creator><creator>Rebbert, M.L</creator><creator>Mozer, B.A</creator><creator>Forquignon, F</creator><creator>Dawid, I.B</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7SS</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>19870401</creationdate><title>Pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein</title><author>Haynes, S.R ; Rebbert, M.L ; Mozer, B.A ; Forquignon, F ; Dawid, I.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3909-1947d8c67d1351e89ac58412ea4c18004b15bb478731607d3f4a6968a80cf1bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ADN</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Complementary DNA</topic><topic>DNA</topic><topic>DNA Helicases - genetics</topic><topic>DNA probes</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DROSOPHILA</topic><topic>Drosophila - genetics</topic><topic>Drosophila - growth & development</topic><topic>Drosophilidae</topic><topic>Genes</topic><topic>GENETICA</topic><topic>GENETICS</topic><topic>GENETIQUE</topic><topic>GENOMAS</topic><topic>GENOME</topic><topic>GENOMES</topic><topic>Genomics</topic><topic>Glycine</topic><topic>NUCLEOTIDE</topic><topic>nucleotide sequence</topic><topic>NUCLEOTIDES</topic><topic>NUCLEOTIDOS</topic><topic>Open reading frames</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>PROTEINS</topic><topic>repeated sequence</topic><topic>Repetitive sequences</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Transcription, Genetic</topic><topic>Viral Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haynes, S.R</creatorcontrib><creatorcontrib>Rebbert, M.L</creatorcontrib><creatorcontrib>Mozer, B.A</creatorcontrib><creatorcontrib>Forquignon, F</creatorcontrib><creatorcontrib>Dawid, I.B</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haynes, S.R</au><au>Rebbert, M.L</au><au>Mozer, B.A</au><au>Forquignon, F</au><au>Dawid, I.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>84</volume><issue>7</issue><spage>1819</spage><epage>1823</epage><pages>1819-1823</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Several cDNA clones that contain the pen repeat have been isolated and sequenced; pen consists of clusters of GGN triplets, where N can be any nucleotide. Some of the pen repeat sequences are found within long open reading frames in which they encode oligoglycine stretches. For one of the clones, the deduced amino acid sequence of the entire open reading frame, especially in the region preceding the glycinerich domain, shows strong homology to the rat helix destabilizing protein [Cobianchi, F., SenGupta, D. N., Zmudzka, B. Z. & Wilson, S. H. (1986) J. Biol. Chem. 261, 3536-3543]. The rat protein and homologs in other organisms are single-stranded nucleic acid binding proteins, some of which are major components of heterogeneous nuclear ribonucleoprotein particles. We suggest that we have cloned a cDNA encoding a Drosophila single-stranded nucleic acid binding protein.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3031652</pmid><doi>10.1073/pnas.84.7.1819</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ADN Amino Acid Sequence Amino acids Animals Base Sequence Complementary DNA DNA DNA Helicases - genetics DNA probes DNA-Binding Proteins - genetics DROSOPHILA Drosophila - genetics Drosophila - growth & development Drosophilidae Genes GENETICA GENETICS GENETIQUE GENOMAS GENOME GENOMES Genomics Glycine NUCLEOTIDE nucleotide sequence NUCLEOTIDES NUCLEOTIDOS Open reading frames PROTEINAS PROTEINE PROTEINS repeated sequence Repetitive sequences Repetitive Sequences, Nucleic Acid Transcription, Genetic Viral Proteins |
| title | Pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein |
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