α-Tocopherol and β-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Idiopathic Parkinson's disease (PD) may possibly be caused by one or more unidentified neurotoxins present in the environment, or formed endogenously, which progressively damage dopaminergic nigrostriatal neurons. N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an experimental neurotoxin...
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| Veröffentlicht in: | Journal of the neurological sciences 1987-11, Vol.81 (2), p.321-331 |
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| creator | Perry, Thomas L. Yong, Voon Wee Hansen, Shirley Jones, Karen Bergeron, Catherine Foulks, James G. Wright, James M. |
| description | Idiopathic Parkinson's disease (PD) may possibly be caused by one or more unidentified neurotoxins present in the environment, or formed endogenously, which progressively damage dopaminergic nigrostriatal neurons.
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an experimental neurotoxin which produces biochemical and neuropathological changes in humans, lower primates and mice that closely resemble those found in PD. Because the mechanisms of neuronal damage in both idiopathic PD and in the MPTP model of PD may involve free radical formation in the substantia nigra, antioxidants might protect dopaminergic neurons. Previously, we found that both α-tocopherol and β-carotene partially protected mice against MPTP. However, in the experiments described in this paper, neither α-tocopherol nor β-carotene, each administered in massive doses, had any demonstrable protective effect for dopaminergic nigrostriatal neurons in marmosets injected with low doses of MPTP. Without more knowledge about the identity of the neurotoxin(s) causing idiopathic PD, and their mechanism of action, it is not possible at this time to predict whether these 2 antioxidants might be clinically useful in preventing or ameliorating PD. |
| doi_str_mv | 10.1016/0022-510X(87)90106-7 |
| format | Article |
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N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an experimental neurotoxin which produces biochemical and neuropathological changes in humans, lower primates and mice that closely resemble those found in PD. Because the mechanisms of neuronal damage in both idiopathic PD and in the MPTP model of PD may involve free radical formation in the substantia nigra, antioxidants might protect dopaminergic neurons. Previously, we found that both α-tocopherol and β-carotene partially protected mice against MPTP. However, in the experiments described in this paper, neither α-tocopherol nor β-carotene, each administered in massive doses, had any demonstrable protective effect for dopaminergic nigrostriatal neurons in marmosets injected with low doses of MPTP. Without more knowledge about the identity of the neurotoxin(s) causing idiopathic PD, and their mechanism of action, it is not possible at this time to predict whether these 2 antioxidants might be clinically useful in preventing or ameliorating PD.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(87)90106-7</identifier><identifier>PMID: 3121800</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; beta Carotene ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Brain - pathology ; Callithrix jacchus ; Callitrichinae - metabolism ; Carotenoids - pharmacology ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Dopamine - metabolism ; Dopaminergic nigrostriatal neurons ; Drug Interactions ; Male ; Marmosets ; Medical sciences ; N-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine ; Neuropharmacology ; Neurotoxins ; Parkinson's disease ; Pharmacology. Drug treatments ; Pyridines - toxicity ; Substantia Nigra - drug effects ; Substantia Nigra - pathology ; Vitamin E - pharmacology ; α-Tocopherol ; β-Carotene</subject><ispartof>Journal of the neurological sciences, 1987-11, Vol.81 (2), p.321-331</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-22a38c92eb50e02f0b0c02fe5abf3b2d25acb6f10877ac389dfdc55694d105683</citedby><cites>FETCH-LOGICAL-c417t-22a38c92eb50e02f0b0c02fe5abf3b2d25acb6f10877ac389dfdc55694d105683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(87)90106-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7783099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3121800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perry, Thomas L.</creatorcontrib><creatorcontrib>Yong, Voon Wee</creatorcontrib><creatorcontrib>Hansen, Shirley</creatorcontrib><creatorcontrib>Jones, Karen</creatorcontrib><creatorcontrib>Bergeron, Catherine</creatorcontrib><creatorcontrib>Foulks, James G.</creatorcontrib><creatorcontrib>Wright, James M.</creatorcontrib><title>α-Tocopherol and β-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Idiopathic Parkinson's disease (PD) may possibly be caused by one or more unidentified neurotoxins present in the environment, or formed endogenously, which progressively damage dopaminergic nigrostriatal neurons.
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an experimental neurotoxin which produces biochemical and neuropathological changes in humans, lower primates and mice that closely resemble those found in PD. Because the mechanisms of neuronal damage in both idiopathic PD and in the MPTP model of PD may involve free radical formation in the substantia nigra, antioxidants might protect dopaminergic neurons. Previously, we found that both α-tocopherol and β-carotene partially protected mice against MPTP. However, in the experiments described in this paper, neither α-tocopherol nor β-carotene, each administered in massive doses, had any demonstrable protective effect for dopaminergic nigrostriatal neurons in marmosets injected with low doses of MPTP. Without more knowledge about the identity of the neurotoxin(s) causing idiopathic PD, and their mechanism of action, it is not possible at this time to predict whether these 2 antioxidants might be clinically useful in preventing or ameliorating PD.</description><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</subject><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>beta Carotene</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Callithrix jacchus</subject><subject>Callitrichinae - metabolism</subject><subject>Carotenoids - pharmacology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Dopaminergic nigrostriatal neurons</subject><subject>Drug Interactions</subject><subject>Male</subject><subject>Marmosets</subject><subject>Medical sciences</subject><subject>N-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine</subject><subject>Neuropharmacology</subject><subject>Neurotoxins</subject><subject>Parkinson's disease</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyridines - toxicity</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - pathology</subject><subject>Vitamin E - pharmacology</subject><subject>α-Tocopherol</subject><subject>β-Carotene</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoYzv6BgpZiIzQ0ST1k9RGkME_GHQzgruQSm5NR6qSMkmL9RDzMPog80ym7KaXrm7C_e65yTkIPWX0FaOsfU0p56Rh9NuFFC87ymhLxD20YVJI0khZ3UebE_IQPUrpO6W0lbI7Q2cV40xSukG3d7_JdTBh3kEMI9be4rs_xOgYMnjANmAfMp7Xq8l40nEKCXLC-kY7nzLOuxWa9eQ8xBtnsId9gcMvZ1xecBjwZzJB3i0jqUlZ4suBbfm22rYkQ456t9gY5iU6WxQeoweDHhM8OdZz9PX9u-vLj-Tqy4dPl2-viKmZyIRzXUnTcegbCpQPtKemFGh0P1Q9t7zRpm8HRqUQ2lSys4M1TdN2tWW0aWV1jl4cdMvHfuwhZTW5ZGActYewT4rVsipWNQWsD6CJIaUIg5qjKy4silG1pqBWi9VqsZJC_UtBiTL27Ki_7yewp6Gj7aX__NjXyehxiNobl06YEGV91xXszQGD4sVPB1El48AbsC6WOJQN7v_v-AsmY6cV</recordid><startdate>19871101</startdate><enddate>19871101</enddate><creator>Perry, Thomas L.</creator><creator>Yong, Voon Wee</creator><creator>Hansen, Shirley</creator><creator>Jones, Karen</creator><creator>Bergeron, Catherine</creator><creator>Foulks, James G.</creator><creator>Wright, James M.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19871101</creationdate><title>α-Tocopherol and β-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine</title><author>Perry, Thomas L. ; Yong, Voon Wee ; Hansen, Shirley ; Jones, Karen ; Bergeron, Catherine ; Foulks, James G. ; Wright, James M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-22a38c92eb50e02f0b0c02fe5abf3b2d25acb6f10877ac389dfdc55694d105683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</topic><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>beta Carotene</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Callithrix jacchus</topic><topic>Callitrichinae - metabolism</topic><topic>Carotenoids - pharmacology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Dopaminergic nigrostriatal neurons</topic><topic>Drug Interactions</topic><topic>Male</topic><topic>Marmosets</topic><topic>Medical sciences</topic><topic>N-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine</topic><topic>Neuropharmacology</topic><topic>Neurotoxins</topic><topic>Parkinson's disease</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyridines - toxicity</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - pathology</topic><topic>Vitamin E - pharmacology</topic><topic>α-Tocopherol</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perry, Thomas L.</creatorcontrib><creatorcontrib>Yong, Voon Wee</creatorcontrib><creatorcontrib>Hansen, Shirley</creatorcontrib><creatorcontrib>Jones, Karen</creatorcontrib><creatorcontrib>Bergeron, Catherine</creatorcontrib><creatorcontrib>Foulks, James G.</creatorcontrib><creatorcontrib>Wright, James M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perry, Thomas L.</au><au>Yong, Voon Wee</au><au>Hansen, Shirley</au><au>Jones, Karen</au><au>Bergeron, Catherine</au><au>Foulks, James G.</au><au>Wright, James M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>α-Tocopherol and β-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1987-11-01</date><risdate>1987</risdate><volume>81</volume><issue>2</issue><spage>321</spage><epage>331</epage><pages>321-331</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Idiopathic Parkinson's disease (PD) may possibly be caused by one or more unidentified neurotoxins present in the environment, or formed endogenously, which progressively damage dopaminergic nigrostriatal neurons.
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an experimental neurotoxin which produces biochemical and neuropathological changes in humans, lower primates and mice that closely resemble those found in PD. Because the mechanisms of neuronal damage in both idiopathic PD and in the MPTP model of PD may involve free radical formation in the substantia nigra, antioxidants might protect dopaminergic neurons. Previously, we found that both α-tocopherol and β-carotene partially protected mice against MPTP. However, in the experiments described in this paper, neither α-tocopherol nor β-carotene, each administered in massive doses, had any demonstrable protective effect for dopaminergic nigrostriatal neurons in marmosets injected with low doses of MPTP. Without more knowledge about the identity of the neurotoxin(s) causing idiopathic PD, and their mechanism of action, it is not possible at this time to predict whether these 2 antioxidants might be clinically useful in preventing or ameliorating PD.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>3121800</pmid><doi>10.1016/0022-510X(87)90106-7</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1987-11, Vol.81 (2), p.321-331 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Anticonvulsants. Antiepileptics. Antiparkinson agents beta Carotene Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Callithrix jacchus Callitrichinae - metabolism Carotenoids - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Dopaminergic nigrostriatal neurons Drug Interactions Male Marmosets Medical sciences N-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine Neuropharmacology Neurotoxins Parkinson's disease Pharmacology. Drug treatments Pyridines - toxicity Substantia Nigra - drug effects Substantia Nigra - pathology Vitamin E - pharmacology α-Tocopherol β-Carotene |
| title | α-Tocopherol and β-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
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