Differential Expression of the Mouse Homeobox-Containing Gene Hox-1.4 during Male Germ Cell Differentiation and Embryonic Development
Hox-1.4 is a mouse homeobox-containing gene (initially identified as HBT-1), whose expression appears to be testis-specific in the adult animal. Examination of Hox-1.4 transcripts in RNA from testes of mutant mice deficient in germ cells confirms that Hox-1.4 expression within the testis is germ cel...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1987-08, Vol.84 (16), p.5813-5817 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Wolgemuth, Debra J. Viviano, Carolyn M. Gizang-Ginsberg, Elena Frohman, Michael A. Joyner, Alexandra L. Martin, Gail R. |
| description | Hox-1.4 is a mouse homeobox-containing gene (initially identified as HBT-1), whose expression appears to be testis-specific in the adult animal. Examination of Hox-1.4 transcripts in RNA from testes of mutant mice deficient in germ cells confirms that Hox-1.4 expression within the testis is germ cell-specific. Enriched populations of spermatogenic cells were used to localize the expression of Hox-1.4 specifically to germ cells that have entered into and progressed beyond the meiotic prophase stage of differentiation and to demonstrate the presence of two different size Hox-1.4 transcripts. Examination of RNA from teratocarcinoma cell cultures and mouse embryos at 10.5-16.5 days of gestation demonstrated the presence of several Hox-1.4 transcripts, which are larger than those present in germ cells. In the midgestation fetus, Hox-1.4 expression is most abundant in the spinal cord. |
| doi_str_mv | 10.1073/pnas.84.16.5813 |
| format | Article |
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Examination of Hox-1.4 transcripts in RNA from testes of mutant mice deficient in germ cells confirms that Hox-1.4 expression within the testis is germ cell-specific. Enriched populations of spermatogenic cells were used to localize the expression of Hox-1.4 specifically to germ cells that have entered into and progressed beyond the meiotic prophase stage of differentiation and to demonstrate the presence of two different size Hox-1.4 transcripts. Examination of RNA from teratocarcinoma cell cultures and mouse embryos at 10.5-16.5 days of gestation demonstrated the presence of several Hox-1.4 transcripts, which are larger than those present in germ cells. In the midgestation fetus, Hox-1.4 expression is most abundant in the spinal cord.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.84.16.5813</identifier><identifier>PMID: 2441396</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Alleles ; Animals ; Biological and medical sciences ; Cell culture techniques ; Cell lines ; Embryos ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation ; Genes ; Genes, Homeobox ; Germ cells ; Male ; Mice ; Molecular and cellular biology ; Molecular genetics ; Mutation ; Nucleic Acid Hybridization ; Poly A - analysis ; Pregnancy ; RNA ; RNA - analysis ; RNA, Messenger ; Somatic cells ; Spinal cord ; Testes ; Testis - cytology ; Testis - embryology ; Transcription, Genetic</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1987-08, Vol.84 (16), p.5813-5817</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-3ecf1b854ff225894f0000de1b1aad3dca72e23ee6c7598823070027dc979d643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/84/16.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30130$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30130$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8342445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2441396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolgemuth, Debra J.</creatorcontrib><creatorcontrib>Viviano, Carolyn M.</creatorcontrib><creatorcontrib>Gizang-Ginsberg, Elena</creatorcontrib><creatorcontrib>Frohman, Michael A.</creatorcontrib><creatorcontrib>Joyner, Alexandra L.</creatorcontrib><creatorcontrib>Martin, Gail R.</creatorcontrib><title>Differential Expression of the Mouse Homeobox-Containing Gene Hox-1.4 during Male Germ Cell Differentiation and Embryonic Development</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Hox-1.4 is a mouse homeobox-containing gene (initially identified as HBT-1), whose expression appears to be testis-specific in the adult animal. Examination of Hox-1.4 transcripts in RNA from testes of mutant mice deficient in germ cells confirms that Hox-1.4 expression within the testis is germ cell-specific. Enriched populations of spermatogenic cells were used to localize the expression of Hox-1.4 specifically to germ cells that have entered into and progressed beyond the meiotic prophase stage of differentiation and to demonstrate the presence of two different size Hox-1.4 transcripts. Examination of RNA from teratocarcinoma cell cultures and mouse embryos at 10.5-16.5 days of gestation demonstrated the presence of several Hox-1.4 transcripts, which are larger than those present in germ cells. In the midgestation fetus, Hox-1.4 expression is most abundant in the spinal cord.</description><subject>Alleles</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell culture techniques</subject><subject>Cell lines</subject><subject>Embryos</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genes, Homeobox</subject><subject>Germ cells</subject><subject>Male</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Mutation</subject><subject>Nucleic Acid Hybridization</subject><subject>Poly A - analysis</subject><subject>Pregnancy</subject><subject>RNA</subject><subject>RNA - analysis</subject><subject>RNA, Messenger</subject><subject>Somatic cells</subject><subject>Spinal cord</subject><subject>Testes</subject><subject>Testis - cytology</subject><subject>Testis - embryology</subject><subject>Transcription, Genetic</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEKtPCGgkJ5AWCVVI7dhJ7wQJNhxapFRtYW45z3bpK7MFOqukD8N51NFFUNqws-Xz33J-TZe8ILghu6PneqVhwVpC6qDihL7INwYLkNRP4ZbbBuGxyzkr2OjuN8R5jLCqOT7KTkjFCRb3J_l5YYyCAG63q0e6wDxCj9Q55g8Y7QDd-ioCu_AC-9Yd8692orLPuFl2Cm4VDTgqGuinMfzeqhySEAW2h79Ez73H2VK5Du6ENj95ZjS7gAXq_H5L-JntlVB_h7fKeZb-_735tr_Lrn5c_tt-uc12VZMwpaENaXjFjyrLigpm0Ee6AtESpjnZaNSWUFKDWTSU4Lylu5hN0WjSiqxk9y74effdTO0CnU-ugerkPdlDhUXpl5b-Ks3fy1j_IUnBR0VT_eakP_s8EcZSDjTqtqhykQ0nCOMWknsHzI6iDjzGAWXsQLOfg5Byc5EySWs7BpYoPz0db-SWppH9adBW16k1QTtu4YpymlFmVsC8LNvuv6tpHmqnvRziMifz4XzIB74_AfRx9WIm0IMX0CXimxEg</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>Wolgemuth, Debra J.</creator><creator>Viviano, Carolyn M.</creator><creator>Gizang-Ginsberg, Elena</creator><creator>Frohman, Michael A.</creator><creator>Joyner, Alexandra L.</creator><creator>Martin, Gail R.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>19870801</creationdate><title>Differential Expression of the Mouse Homeobox-Containing Gene Hox-1.4 during Male Germ Cell Differentiation and Embryonic Development</title><author>Wolgemuth, Debra J. ; Viviano, Carolyn M. ; Gizang-Ginsberg, Elena ; Frohman, Michael A. ; Joyner, Alexandra L. ; Martin, Gail R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-3ecf1b854ff225894f0000de1b1aad3dca72e23ee6c7598823070027dc979d643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell culture techniques</topic><topic>Cell lines</topic><topic>Embryos</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Genes, Homeobox</topic><topic>Germ cells</topic><topic>Male</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Mutation</topic><topic>Nucleic Acid Hybridization</topic><topic>Poly A - analysis</topic><topic>Pregnancy</topic><topic>RNA</topic><topic>RNA - analysis</topic><topic>RNA, Messenger</topic><topic>Somatic cells</topic><topic>Spinal cord</topic><topic>Testes</topic><topic>Testis - cytology</topic><topic>Testis - embryology</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolgemuth, Debra J.</creatorcontrib><creatorcontrib>Viviano, Carolyn M.</creatorcontrib><creatorcontrib>Gizang-Ginsberg, Elena</creatorcontrib><creatorcontrib>Frohman, Michael A.</creatorcontrib><creatorcontrib>Joyner, Alexandra L.</creatorcontrib><creatorcontrib>Martin, Gail R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolgemuth, Debra J.</au><au>Viviano, Carolyn M.</au><au>Gizang-Ginsberg, Elena</au><au>Frohman, Michael A.</au><au>Joyner, Alexandra L.</au><au>Martin, Gail R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Expression of the Mouse Homeobox-Containing Gene Hox-1.4 during Male Germ Cell Differentiation and Embryonic Development</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>84</volume><issue>16</issue><spage>5813</spage><epage>5817</epage><pages>5813-5817</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Hox-1.4 is a mouse homeobox-containing gene (initially identified as HBT-1), whose expression appears to be testis-specific in the adult animal. Examination of Hox-1.4 transcripts in RNA from testes of mutant mice deficient in germ cells confirms that Hox-1.4 expression within the testis is germ cell-specific. Enriched populations of spermatogenic cells were used to localize the expression of Hox-1.4 specifically to germ cells that have entered into and progressed beyond the meiotic prophase stage of differentiation and to demonstrate the presence of two different size Hox-1.4 transcripts. Examination of RNA from teratocarcinoma cell cultures and mouse embryos at 10.5-16.5 days of gestation demonstrated the presence of several Hox-1.4 transcripts, which are larger than those present in germ cells. In the midgestation fetus, Hox-1.4 expression is most abundant in the spinal cord.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2441396</pmid><doi>10.1073/pnas.84.16.5813</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Animals Biological and medical sciences Cell culture techniques Cell lines Embryos Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Genes Genes, Homeobox Germ cells Male Mice Molecular and cellular biology Molecular genetics Mutation Nucleic Acid Hybridization Poly A - analysis Pregnancy RNA RNA - analysis RNA, Messenger Somatic cells Spinal cord Testes Testis - cytology Testis - embryology Transcription, Genetic |
| title | Differential Expression of the Mouse Homeobox-Containing Gene Hox-1.4 during Male Germ Cell Differentiation and Embryonic Development |
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