The effect of chronic application of kanamycin on stereocilia and their tip links in hair cells of the guinea pig cochlea

Albino guinea pigs were treated with kanamycin (400 mg/kg i.p.) daily for 10 days. After a 2-week recovery period their cochleae were analyzed by scanning electron microscopy. Attention was paid to those outer hair cells which had been less severely damaged. Stereocilia of the outer hair cells were...

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Veröffentlicht in:	Hearing research 1987, Vol.29 (2), p.237-244
Hauptverfasser:	Pickles, J.O., Comis, S.D., Osborne, M.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cilia - drug effects Cilia - ultrastructure Cochlear hair cell Cross-link Drug toxicity and drugs side effects treatment Guinea pig Guinea Pigs Hair Cells, Auditory - drug effects Hair Cells, Auditory - ultrastructure Kanamycin Kanamycin - toxicity Medical sciences Microscopy, Electron, Scanning Pharmacology. Drug treatments Stereocilium Toxicity: nervous system and muscle Transduction
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